FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125443638> ?p ?o ?g. }

• W2125443638 endingPage "e30668" @default.
• W2125443638 startingPage "e30668" @default.
• W2125443638 abstract "Background & Aims Non-alcoholic steatohepatitis (NASH) involves steatosis combined with inflammation, which can progress into fibrosis and cirrhosis. Exploring the molecular mechanisms of NASH is highly dependent on the availability of animal models. Currently, the most commonly used animal models for NASH imitate particularly late stages of human disease. Thus, there is a need for an animal model that can be used for investigating the factors that potentiate the inflammatory response within NASH. We have previously shown that 7-day high-fat-high-cholesterol (HFC) feeding induces steatosis and inflammation in both APOE2ki and Ldlr−/− mice. However, it is not known whether the early inflammatory response observed in these mice will sustain over time and lead to liver damage. We hypothesized that the inflammatory response in both models is sufficient to induce liver damage over time. Methods APOE2ki and Ldlr−/− mice were fed a chow or HFC diet for 3 months. C57Bl6/J mice were used as control. Results Surprisingly, hepatic inflammation was abolished in APOE2ki mice, while it was sustained in Ldlr−/− mice. In addition, increased apoptosis and hepatic fibrosis was only demonstrated in Ldlr−/− mice. Finally, bone-marrow-derived-macrophages of Ldlr−/− mice showed an increased inflammatory response after oxidized LDL (oxLDL) loading compared to APOE2ki mice. Conclusion Ldlr−/− mice, but not APOE2ki mice, developed sustained hepatic inflammation and liver damage upon long term HFC feeding due to increased sensitivity for oxLDL uptake. Therefore, the Ldlr−/− mice are a promising physiological model particularly vulnerable for investigating the onset of hepatic inflammation in non-alcoholic steatohepatitis." @default.
• W2125443638 created "2016-06-24" @default.
• W2125443638 creator A5001127450 @default.
• W2125443638 creator A5020668415 @default.
• W2125443638 creator A5033865421 @default.
• W2125443638 creator A5041231136 @default.
• W2125443638 creator A5063740703 @default.
• W2125443638 creator A5071412244 @default.
• W2125443638 creator A5074042132 @default.
• W2125443638 creator A5079401811 @default.
• W2125443638 creator A5082105014 @default.
• W2125443638 creator A5082220990 @default.
• W2125443638 creator A5086707368 @default.
• W2125443638 creator A5090786163 @default.
• W2125443638 date "2012-01-25" @default.
• W2125443638 modified "2023-09-25" @default.
• W2125443638 title "LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease" @default.
• W2125443638 cites W1523155649 @default.
• W2125443638 cites W1724319488 @default.
• W2125443638 cites W1895277992 @default.
• W2125443638 cites W1968283484 @default.
• W2125443638 cites W1969295126 @default.
• W2125443638 cites W1972960247 @default.
• W2125443638 cites W1975654965 @default.
• W2125443638 cites W1985859760 @default.
• W2125443638 cites W2002883142 @default.
• W2125443638 cites W2009182898 @default.
• W2125443638 cites W2016661258 @default.
• W2125443638 cites W2020438152 @default.
• W2125443638 cites W2022016504 @default.
• W2125443638 cites W2022030431 @default.
• W2125443638 cites W2029772870 @default.
• W2125443638 cites W2033957878 @default.
• W2125443638 cites W2035252462 @default.
• W2125443638 cites W2035313241 @default.
• W2125443638 cites W2040579726 @default.
• W2125443638 cites W2040676625 @default.
• W2125443638 cites W2042555983 @default.
• W2125443638 cites W2045672949 @default.
• W2125443638 cites W2048890665 @default.
• W2125443638 cites W2049401036 @default.
• W2125443638 cites W2056888748 @default.
• W2125443638 cites W2070053386 @default.
• W2125443638 cites W2072422194 @default.
• W2125443638 cites W2073438109 @default.
• W2125443638 cites W2085154029 @default.
• W2125443638 cites W2092412521 @default.
• W2125443638 cites W2102161788 @default.
• W2125443638 cites W2121509986 @default.
• W2125443638 cites W2125720510 @default.
• W2125443638 cites W2126390506 @default.
• W2125443638 cites W2136847524 @default.
• W2125443638 cites W2139776835 @default.
• W2125443638 cites W2149252084 @default.
• W2125443638 cites W2164961630 @default.
• W2125443638 cites W2328284874 @default.
• W2125443638 cites W4247956906 @default.
• W2125443638 cites W4252134514 @default.
• W2125443638 doi "https://doi.org/10.1371/journal.pone.0030668" @default.
• W2125443638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3266276" @default.
• W2125443638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22295101" @default.
• W2125443638 hasPublicationYear "2012" @default.
• W2125443638 type Work @default.
• W2125443638 sameAs 2125443638 @default.
• W2125443638 citedByCount "133" @default.
• W2125443638 countsByYear W21254436382012 @default.
• W2125443638 countsByYear W21254436382013 @default.
• W2125443638 countsByYear W21254436382014 @default.
• W2125443638 countsByYear W21254436382015 @default.
• W2125443638 countsByYear W21254436382016 @default.
• W2125443638 countsByYear W21254436382017 @default.
• W2125443638 countsByYear W21254436382018 @default.
• W2125443638 countsByYear W21254436382019 @default.
• W2125443638 countsByYear W21254436382020 @default.
• W2125443638 countsByYear W21254436382021 @default.
• W2125443638 countsByYear W21254436382022 @default.
• W2125443638 countsByYear W21254436382023 @default.
• W2125443638 crossrefType "journal-article" @default.
• W2125443638 hasAuthorship W2125443638A5001127450 @default.
• W2125443638 hasAuthorship W2125443638A5020668415 @default.
• W2125443638 hasAuthorship W2125443638A5033865421 @default.
• W2125443638 hasAuthorship W2125443638A5041231136 @default.
• W2125443638 hasAuthorship W2125443638A5063740703 @default.
• W2125443638 hasAuthorship W2125443638A5071412244 @default.
• W2125443638 hasAuthorship W2125443638A5074042132 @default.
• W2125443638 hasAuthorship W2125443638A5079401811 @default.
• W2125443638 hasAuthorship W2125443638A5082105014 @default.
• W2125443638 hasAuthorship W2125443638A5082220990 @default.
• W2125443638 hasAuthorship W2125443638A5086707368 @default.
• W2125443638 hasAuthorship W2125443638A5090786163 @default.
• W2125443638 hasBestOaLocation W21254436381 @default.
• W2125443638 hasConcept C126322002 @default.
• W2125443638 hasConcept C134018914 @default.
• W2125443638 hasConcept C203014093 @default.
• W2125443638 hasConcept C2776175330 @default.
• W2125443638 hasConcept C2776914184 @default.
• W2125443638 hasConcept C2777214474 @default.
• W2125443638 hasConcept C2777575235 @default.

• next