FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125460037> ?p ?o ?g. }

• W2125460037 endingPage "977" @default.
• W2125460037 startingPage "969" @default.
• W2125460037 abstract "ABSTRACT A double-blind, randomized, controlled phase I study to assess the safety, immunogenicity, and antibody persistence of a new group A conjugate vaccine (PsA-TT) in volunteers aged 18 to 35 years was previously performed. Subjects received one dose of either the PsA-TT conjugate vaccine, meningococcal A/C polysaccharide vaccine (PsA/C), or tetanus toxoid vaccine. The conjugate vaccine was shown to be safe and immunogenic as demonstrated by a standardized group A-specific immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) and by a serum bactericidal antibody (SBA) assay using rabbit complement (rSBA). This report details further analysis of the sera using four additional immunologic assays to investigate the relationship between the different immunoassays. The immunoassays used were an SBA assay that used human complement (hSBA), a group A-specific IgG multiplexed bead assay, and two opsonophagocytic antibody (OPA) assays which used two different methodologies. For each vaccine group, geometric mean concentrations or geometric mean titers were determined for all assays before and 4, 24, and 48 weeks after vaccination. Pearson's correlation coefficients were used to assess the relationship between the six assays using data from all available visits. An excellent correlation was observed between the group A-specific IgG concentrations obtained by ELISA and those obtained by the multiplexed bead assay. hSBA and rSBA titers correlated moderately, although proportions of subjects with putatively protective titers and those demonstrating a ≥4-fold rise were similar. The two OPA methods correlated weakly and achieved only a low correlation with the other immunoassays. The correlation between hSBA and group A-specific IgG was higher for the PsA-TT group than for the PsA/C group." @default.
• W2125460037 created "2016-06-24" @default.
• W2125460037 creator A5003735630 @default.
• W2125460037 creator A5014246647 @default.
• W2125460037 creator A5014739309 @default.
• W2125460037 creator A5016743366 @default.
• W2125460037 creator A5029181889 @default.
• W2125460037 creator A5034767468 @default.
• W2125460037 creator A5039280458 @default.
• W2125460037 creator A5044154431 @default.
• W2125460037 creator A5047279451 @default.
• W2125460037 creator A5048843231 @default.
• W2125460037 creator A5050450991 @default.
• W2125460037 creator A5050917479 @default.
• W2125460037 creator A5060822288 @default.
• W2125460037 creator A5064295733 @default.
• W2125460037 creator A5065878916 @default.
• W2125460037 creator A5076130506 @default.
• W2125460037 creator A5079602397 @default.
• W2125460037 creator A5083312378 @default.
• W2125460037 creator A5089294008 @default.
• W2125460037 creator A5090810881 @default.
• W2125460037 date "2009-07-01" @default.
• W2125460037 modified "2023-09-26" @default.
• W2125460037 title "Investigation of Different Group A Immunoassays following One Dose of Meningococcal Group A Conjugate Vaccine or A/C Polysaccharide Vaccine in Adults" @default.
• W2125460037 cites W1912692997 @default.
• W2125460037 cites W1995744055 @default.
• W2125460037 cites W2012619809 @default.
• W2125460037 cites W2046267384 @default.
• W2125460037 cites W2050893840 @default.
• W2125460037 cites W2050982645 @default.
• W2125460037 cites W2052490461 @default.
• W2125460037 cites W2060925765 @default.
• W2125460037 cites W2092326939 @default.
• W2125460037 cites W2098499618 @default.
• W2125460037 cites W2099249077 @default.
• W2125460037 cites W2115350923 @default.
• W2125460037 cites W2118976076 @default.
• W2125460037 cites W2121745520 @default.
• W2125460037 cites W2128589740 @default.
• W2125460037 cites W2130431177 @default.
• W2125460037 cites W2130460485 @default.
• W2125460037 cites W2132181699 @default.
• W2125460037 cites W2134778321 @default.
• W2125460037 cites W2153708533 @default.
• W2125460037 cites W2157980489 @default.
• W2125460037 cites W2165843807 @default.
• W2125460037 cites W2321499758 @default.
• W2125460037 doi "https://doi.org/10.1128/cvi.00068-09" @default.
• W2125460037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2708411" @default.
• W2125460037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19474264" @default.
• W2125460037 hasPublicationYear "2009" @default.
• W2125460037 type Work @default.
• W2125460037 sameAs 2125460037 @default.
• W2125460037 citedByCount "23" @default.
• W2125460037 countsByYear W21254600372012 @default.
• W2125460037 countsByYear W21254600372013 @default.
• W2125460037 countsByYear W21254600372014 @default.
• W2125460037 countsByYear W21254600372015 @default.
• W2125460037 countsByYear W21254600372016 @default.
• W2125460037 countsByYear W21254600372020 @default.
• W2125460037 countsByYear W21254600372021 @default.
• W2125460037 crossrefType "journal-article" @default.
• W2125460037 hasAuthorship W2125460037A5003735630 @default.
• W2125460037 hasAuthorship W2125460037A5014246647 @default.
• W2125460037 hasAuthorship W2125460037A5014739309 @default.
• W2125460037 hasAuthorship W2125460037A5016743366 @default.
• W2125460037 hasAuthorship W2125460037A5029181889 @default.
• W2125460037 hasAuthorship W2125460037A5034767468 @default.
• W2125460037 hasAuthorship W2125460037A5039280458 @default.
• W2125460037 hasAuthorship W2125460037A5044154431 @default.
• W2125460037 hasAuthorship W2125460037A5047279451 @default.
• W2125460037 hasAuthorship W2125460037A5048843231 @default.
• W2125460037 hasAuthorship W2125460037A5050450991 @default.
• W2125460037 hasAuthorship W2125460037A5050917479 @default.
• W2125460037 hasAuthorship W2125460037A5060822288 @default.
• W2125460037 hasAuthorship W2125460037A5064295733 @default.
• W2125460037 hasAuthorship W2125460037A5065878916 @default.
• W2125460037 hasAuthorship W2125460037A5076130506 @default.
• W2125460037 hasAuthorship W2125460037A5079602397 @default.
• W2125460037 hasAuthorship W2125460037A5083312378 @default.
• W2125460037 hasAuthorship W2125460037A5089294008 @default.
• W2125460037 hasAuthorship W2125460037A5090810881 @default.
• W2125460037 hasBestOaLocation W21254600371 @default.
• W2125460037 hasConcept C126322002 @default.
• W2125460037 hasConcept C134306372 @default.
• W2125460037 hasConcept C159654299 @default.
• W2125460037 hasConcept C197336794 @default.
• W2125460037 hasConcept C203014093 @default.
• W2125460037 hasConcept C22070199 @default.
• W2125460037 hasConcept C2777351567 @default.
• W2125460037 hasConcept C2777785397 @default.
• W2125460037 hasConcept C2778458888 @default.
• W2125460037 hasConcept C2779583294 @default.
• W2125460037 hasConcept C2779841045 @default.
• W2125460037 hasConcept C2780420688 @default.
• W2125460037 hasConcept C2780454893 @default.
• W2125460037 hasConcept C2780801004 @default.

• next