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- W2125467449 endingPage "296" @default.
- W2125467449 startingPage "287" @default.
- W2125467449 abstract "Altering endogenous genes in cells is an integral tool of modern cell biology. The ease-of-use of the CRISPR/Cas9 system to introduce genomic DNA breaks at specific sites in vivo has led to its rapid and wide adoption. In the absence of a DNA template, the lesion is repaired by nonhomologous end joining resolving as internal deletions. However, in the presence of a homologous DNA template, homology-directed repair occurs with variable efficiencies. Recent work has demonstrated that highly efficient gene targeting can be induced by combining CRISPR/Cas9 targeting of genomic loci with recombinant adeno-associated virus (rAAV) to provide a single-stranded homologous DNA template. Here we review the current state of CRISPR/Cas-based gene editing and provide a practical guide to applying the CRISPR/Cas and rAAV system for highly efficient, time- and cost-effective gene targeting." @default.
- W2125467449 created "2016-06-24" @default.
- W2125467449 creator A5048054072 @default.
- W2125467449 creator A5050030738 @default.
- W2125467449 date "2015-12-01" @default.
- W2125467449 modified "2023-10-15" @default.
- W2125467449 title "Combining CRISPR/Cas9 and rAAV Templates for Efficient Gene Editing" @default.
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