FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125471117> ?p ?o ?g. }

• W2125471117 endingPage "1245" @default.
• W2125471117 startingPage "1237" @default.
• W2125471117 abstract "The Na/K-ATPase was discovered as an energy transducing ion pump. A major difference between the Na/K-ATPase and other P-type ATPases is its ability to bind a group of chemicals called cardiotonic steroids (CTS). The plant-derived CTS such as digoxin are valuable drugs for the management of cardiac diseases, whereas ouabain and marinobufagenin (MBG) have been identified as a new class of endogenous hormones. Recent studies have demonstrated that the endogenous CTS are important regulators of renal Na+ excretion and blood pressure. The Na/K-ATPase is not only an ion pump, but also an important receptor that can transduce the ligand-like effect of CTS on intracellular protein kinases and Ca2+ signaling. Significantly, these CTS-provoked signaling events are capable of reducing the surface expression of apical NHE3 (Na/H exchanger isoform 3) and basolateral Na/K-ATPase in renal proximal tubular cells. These findings suggest that endogenous CTS may play an important role in regulation of tubular Na+ excretion under physiological conditions; conversely, a defect at either the receptor level (Na/K-ATPase) or receptor–effector coupling would reduce the ability of renal proximal tubular cells to excrete Na+, thus culminating/resulting in salt-sensitive hypertension." @default.
• W2125471117 created "2016-06-24" @default.
• W2125471117 creator A5004658590 @default.
• W2125471117 creator A5025749942 @default.
• W2125471117 date "2010-12-01" @default.
• W2125471117 modified "2023-09-27" @default.
• W2125471117 title "The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking" @default.
• W2125471117 cites W1508102251 @default.
• W2125471117 cites W1545964478 @default.
• W2125471117 cites W1548022389 @default.
• W2125471117 cites W1576990557 @default.
• W2125471117 cites W1589657989 @default.
• W2125471117 cites W1590442083 @default.
• W2125471117 cites W1606161617 @default.
• W2125471117 cites W1687906556 @default.
• W2125471117 cites W1930917734 @default.
• W2125471117 cites W1966519432 @default.
• W2125471117 cites W1966594228 @default.
• W2125471117 cites W1968185983 @default.
• W2125471117 cites W1969955179 @default.
• W2125471117 cites W1970128059 @default.
• W2125471117 cites W1972598425 @default.
• W2125471117 cites W1973480659 @default.
• W2125471117 cites W1975264864 @default.
• W2125471117 cites W1976270302 @default.
• W2125471117 cites W1980142140 @default.
• W2125471117 cites W1982240282 @default.
• W2125471117 cites W1983012115 @default.
• W2125471117 cites W1984687894 @default.
• W2125471117 cites W1991683855 @default.
• W2125471117 cites W1994168674 @default.
• W2125471117 cites W1994836734 @default.
• W2125471117 cites W1995975621 @default.
• W2125471117 cites W1995995223 @default.
• W2125471117 cites W1996355148 @default.
• W2125471117 cites W1996510966 @default.
• W2125471117 cites W1997785224 @default.
• W2125471117 cites W1998485930 @default.
• W2125471117 cites W2001243825 @default.
• W2125471117 cites W2001388306 @default.
• W2125471117 cites W2002119373 @default.
• W2125471117 cites W2002473468 @default.
• W2125471117 cites W2003281368 @default.
• W2125471117 cites W2003541226 @default.
• W2125471117 cites W2004169125 @default.
• W2125471117 cites W2004347894 @default.
• W2125471117 cites W2004763365 @default.
• W2125471117 cites W2007979148 @default.
• W2125471117 cites W2011117142 @default.
• W2125471117 cites W2011173660 @default.
• W2125471117 cites W2015016276 @default.
• W2125471117 cites W2017241167 @default.
• W2125471117 cites W2017679403 @default.
• W2125471117 cites W2019490673 @default.
• W2125471117 cites W2022058053 @default.
• W2125471117 cites W2026624253 @default.
• W2125471117 cites W2027098759 @default.
• W2125471117 cites W2029954557 @default.
• W2125471117 cites W2032292804 @default.
• W2125471117 cites W2033076676 @default.
• W2125471117 cites W2038376484 @default.
• W2125471117 cites W2038753606 @default.
• W2125471117 cites W2040966940 @default.
• W2125471117 cites W2042006767 @default.
• W2125471117 cites W2043616500 @default.
• W2125471117 cites W2044612296 @default.
• W2125471117 cites W2045014613 @default.
• W2125471117 cites W2045094350 @default.
• W2125471117 cites W2046828489 @default.
• W2125471117 cites W2046904899 @default.
• W2125471117 cites W2046924003 @default.
• W2125471117 cites W2047057549 @default.
• W2125471117 cites W2049162475 @default.
• W2125471117 cites W2049414505 @default.
• W2125471117 cites W2049697696 @default.
• W2125471117 cites W2050553080 @default.
• W2125471117 cites W2050728158 @default.
• W2125471117 cites W2053972094 @default.
• W2125471117 cites W2054003452 @default.
• W2125471117 cites W2055224075 @default.
• W2125471117 cites W2055941645 @default.
• W2125471117 cites W2057863669 @default.
• W2125471117 cites W2058589233 @default.
• W2125471117 cites W2059251599 @default.
• W2125471117 cites W2059496396 @default.
• W2125471117 cites W2065289702 @default.
• W2125471117 cites W2067387269 @default.
• W2125471117 cites W2069331190 @default.
• W2125471117 cites W2072856314 @default.
• W2125471117 cites W2073411380 @default.
• W2125471117 cites W2078152971 @default.
• W2125471117 cites W2079448952 @default.
• W2125471117 cites W2079486967 @default.
• W2125471117 cites W2079993971 @default.
• W2125471117 cites W2081787890 @default.
• W2125471117 cites W2082295460 @default.
• W2125471117 cites W2082602069 @default.
• W2125471117 cites W2082786285 @default.

• next