FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125471316> ?p ?o ?g. }

• W2125471316 endingPage "5265" @default.
• W2125471316 startingPage "5255" @default.
• W2125471316 abstract "Using in situ hybridization labelling methods, we have determined that the herpes simplex virus type 1 immediate-early protein IE63 (ICP27) affects the cellular localization of virus transcripts. Intronless transcripts from the IE63, UL38, and UL44 genes are rapidly exported to and accumulate in the cytoplasm throughout infection, in either the presence or absence of IE63 expression. The intron-containing transcripts from the IE110 and UL15 genes, while initially cytoplasmic, are increasingly retained in the nucleus in distinct clumps as infection proceeds, and the clumps colocalize with the redistributed small nuclear ribonucleoprotein particles. Infections with the IE63 mutant virus 27-lacZ demonstrated that in the absence of IE63 expression, nuclear retention of intron-containing transcripts was lost. The nuclear retention of UL15 transcripts, which demonstrated both nuclear and cytoplasmic label, was not as pronounced as that of the IE110 transcripts, and we propose that this is due to the late expression of UL15. Infections with the mutant virus 110C1, in which both introns of IE110 have been precisely removed (R.D. Everett, J. Gen. Virol. 72:651-659, 1991), demonstrated IE110 transcripts in both the nucleus and the cytoplasm; thus, exon definition sequences which regulate viral RNA transport are present in the IE110 transcript. By in situ hybridization a stable population of polyadenylated RNAs was found to accumulate in the nucleus in spots, most of which were separate from the small nuclear ribonucleoprotein particle clumps. The IE63 protein has an involvement, either direct or indirect, in the regulation of nucleocytoplasmic transport of viral transcripts, a function which contrasts with the recently proposed role of herpes simplex virus type 1 Us11 in promoting the nuclear export of partially spliced or unspliced transcripts (J.-J. Diaz, M. Duc Dodon, N. Schaerer-Uthurraly, D. Simonin, K. Kindbeiter, L. Gazzolo, and J.-J. Madjar, Nature [London] 379:273-277, 1996), the significance of which is discussed." @default.
• W2125471316 created "2016-06-24" @default.
• W2125471316 creator A5001047119 @default.
• W2125471316 creator A5002496378 @default.
• W2125471316 creator A5079233773 @default.
• W2125471316 date "1996-08-01" @default.
• W2125471316 modified "2023-10-12" @default.
• W2125471316 title "Herpes simplex virus type 1 protein IE63 affects the nuclear export of virus intron-containing transcripts" @default.
• W2125471316 cites W135925168 @default.
• W2125471316 cites W1483156497 @default.
• W2125471316 cites W1531621505 @default.
• W2125471316 cites W1534833050 @default.
• W2125471316 cites W1535683449 @default.
• W2125471316 cites W1583466448 @default.
• W2125471316 cites W1597953111 @default.
• W2125471316 cites W1606830172 @default.
• W2125471316 cites W1614944940 @default.
• W2125471316 cites W1628312488 @default.
• W2125471316 cites W1733825645 @default.
• W2125471316 cites W1771001171 @default.
• W2125471316 cites W1834610545 @default.
• W2125471316 cites W1839421179 @default.
• W2125471316 cites W1849971351 @default.
• W2125471316 cites W1854770036 @default.
• W2125471316 cites W1890282385 @default.
• W2125471316 cites W1895304651 @default.
• W2125471316 cites W1900646268 @default.
• W2125471316 cites W1904099063 @default.
• W2125471316 cites W1922329782 @default.
• W2125471316 cites W1927078541 @default.
• W2125471316 cites W1937676201 @default.
• W2125471316 cites W1940400153 @default.
• W2125471316 cites W1951335634 @default.
• W2125471316 cites W1964340993 @default.
• W2125471316 cites W1964629933 @default.
• W2125471316 cites W1969445083 @default.
• W2125471316 cites W1973014323 @default.
• W2125471316 cites W1974534167 @default.
• W2125471316 cites W1977435924 @default.
• W2125471316 cites W1981599663 @default.
• W2125471316 cites W1984734782 @default.
• W2125471316 cites W2003574926 @default.
• W2125471316 cites W2004635090 @default.
• W2125471316 cites W2006301581 @default.
• W2125471316 cites W2008922773 @default.
• W2125471316 cites W2012030402 @default.
• W2125471316 cites W2014672146 @default.
• W2125471316 cites W2029650577 @default.
• W2125471316 cites W2034329243 @default.
• W2125471316 cites W2037520015 @default.
• W2125471316 cites W2047079821 @default.
• W2125471316 cites W2047427478 @default.
• W2125471316 cites W2048167369 @default.
• W2125471316 cites W2050776627 @default.
• W2125471316 cites W2056650797 @default.
• W2125471316 cites W2064346614 @default.
• W2125471316 cites W2067382966 @default.
• W2125471316 cites W2070648411 @default.
• W2125471316 cites W2080568795 @default.
• W2125471316 cites W2083340704 @default.
• W2125471316 cites W2089107397 @default.
• W2125471316 cites W2094733358 @default.
• W2125471316 cites W2104329747 @default.
• W2125471316 cites W2110615225 @default.
• W2125471316 cites W2110789340 @default.
• W2125471316 cites W2114142573 @default.
• W2125471316 cites W2118300475 @default.
• W2125471316 cites W2125112566 @default.
• W2125471316 cites W2129566110 @default.
• W2125471316 cites W2134275666 @default.
• W2125471316 cites W2137595520 @default.
• W2125471316 cites W2140576339 @default.
• W2125471316 cites W2147990979 @default.
• W2125471316 cites W2150562155 @default.
• W2125471316 cites W2151018530 @default.
• W2125471316 cites W2151199680 @default.
• W2125471316 cites W2156102853 @default.
• W2125471316 cites W2166195788 @default.
• W2125471316 cites W2167414261 @default.
• W2125471316 cites W2168494912 @default.
• W2125471316 cites W2168803152 @default.
• W2125471316 cites W2419032016 @default.
• W2125471316 doi "https://doi.org/10.1128/jvi.70.8.5255-5265.1996" @default.
• W2125471316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/190482" @default.
• W2125471316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8764035" @default.
• W2125471316 hasPublicationYear "1996" @default.
• W2125471316 type Work @default.
• W2125471316 sameAs 2125471316 @default.
• W2125471316 citedByCount "64" @default.
• W2125471316 countsByYear W21254713162013 @default.
• W2125471316 countsByYear W21254713162015 @default.
• W2125471316 countsByYear W21254713162017 @default.
• W2125471316 countsByYear W21254713162018 @default.
• W2125471316 countsByYear W21254713162019 @default.
• W2125471316 crossrefType "journal-article" @default.
• W2125471316 hasAuthorship W2125471316A5001047119 @default.
• W2125471316 hasAuthorship W2125471316A5002496378 @default.
• W2125471316 hasAuthorship W2125471316A5079233773 @default.

• next