Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125492065> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2125492065 abstract "S-1, an oral fluorouracil antitumor drug, is composed of three agents: tegafur (FT), 5-chloro-2,4-dihydroxypyridine (CDHP), and potassium oxonate (Oxo). Approximately 50% of oral squamous cell carcinomas (OSCC) exhibit cervical lymph node metastasis. The extent of lymph node involvement is a major determinant in both staging and prognosis of the majority of OSCC. The purpose of this study was to examine the effect of S-1 on the metastatic potential of OSCC cells. We used orthotopic green fluorescence protein (GFP) SAS-L1, in BALB/c nu/nu mice. Mice received oral doses of either 5% hydroxypropylmethylcellulose (HPMC) for control or S-1 (20 mg/kg) and were autopsied at 2 weeks. We also performed in vitro experiments using concomitant 5-fluorouracil (5-FU) and CDHP as a drug model of S-1 to determine the effect of S-1 on OSCC invasion and metastasis. Although 100% (11 of 11) of mice not treated with S-1 showed cervical lymph node metastasis, only 54.4% (6 of 11) of S-1 treated mice demonstrated metastasis. In in vitro experiments, OSCC cells treated with 5-FU and CDHP showed a marked reduction in invasiveness and in adhesion to laminin coated plates. Western blot analysis revealed that treatment with 5-FU and CDHP suppressed expression of integrins αv, α3, α6, β1, β3, β4, β5, and β6. These results suggest that S-1 inhibits tumor proliferation and lymph node metastasis in OSCC cells. Moreover, expression of integrin subunits and the integrin signal transduction pathway may be closely related to metastasis suppression." @default.
- W2125492065 created "2016-06-24" @default.
- W2125492065 creator A5048279225 @default.
- W2125492065 creator A5049139606 @default.
- W2125492065 creator A5049579503 @default.
- W2125492065 creator A5053265924 @default.
- W2125492065 creator A5068398956 @default.
- W2125492065 creator A5073939971 @default.
- W2125492065 creator A5085087306 @default.
- W2125492065 creator A5090750541 @default.
- W2125492065 date "2009-08-31" @default.
- W2125492065 modified "2023-10-16" @default.
- W2125492065 title "S-1 mediates the inhibition of lymph node metastasis in oral cancer cells" @default.
- W2125492065 doi "https://doi.org/10.3892/or_00000492" @default.
- W2125492065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19724848" @default.
- W2125492065 hasPublicationYear "2009" @default.
- W2125492065 type Work @default.
- W2125492065 sameAs 2125492065 @default.
- W2125492065 citedByCount "2" @default.
- W2125492065 countsByYear W21254920652023 @default.
- W2125492065 crossrefType "journal-article" @default.
- W2125492065 hasAuthorship W2125492065A5048279225 @default.
- W2125492065 hasAuthorship W2125492065A5049139606 @default.
- W2125492065 hasAuthorship W2125492065A5049579503 @default.
- W2125492065 hasAuthorship W2125492065A5053265924 @default.
- W2125492065 hasAuthorship W2125492065A5068398956 @default.
- W2125492065 hasAuthorship W2125492065A5073939971 @default.
- W2125492065 hasAuthorship W2125492065A5085087306 @default.
- W2125492065 hasAuthorship W2125492065A5090750541 @default.
- W2125492065 hasBestOaLocation W21254920651 @default.
- W2125492065 hasConcept C121608353 @default.
- W2125492065 hasConcept C126322002 @default.
- W2125492065 hasConcept C142724271 @default.
- W2125492065 hasConcept C1491633281 @default.
- W2125492065 hasConcept C170493617 @default.
- W2125492065 hasConcept C195687474 @default.
- W2125492065 hasConcept C2779013556 @default.
- W2125492065 hasConcept C2780849966 @default.
- W2125492065 hasConcept C2781018059 @default.
- W2125492065 hasConcept C29537977 @default.
- W2125492065 hasConcept C502942594 @default.
- W2125492065 hasConcept C54355233 @default.
- W2125492065 hasConcept C71924100 @default.
- W2125492065 hasConcept C86803240 @default.
- W2125492065 hasConceptScore W2125492065C121608353 @default.
- W2125492065 hasConceptScore W2125492065C126322002 @default.
- W2125492065 hasConceptScore W2125492065C142724271 @default.
- W2125492065 hasConceptScore W2125492065C1491633281 @default.
- W2125492065 hasConceptScore W2125492065C170493617 @default.
- W2125492065 hasConceptScore W2125492065C195687474 @default.
- W2125492065 hasConceptScore W2125492065C2779013556 @default.
- W2125492065 hasConceptScore W2125492065C2780849966 @default.
- W2125492065 hasConceptScore W2125492065C2781018059 @default.
- W2125492065 hasConceptScore W2125492065C29537977 @default.
- W2125492065 hasConceptScore W2125492065C502942594 @default.
- W2125492065 hasConceptScore W2125492065C54355233 @default.
- W2125492065 hasConceptScore W2125492065C71924100 @default.
- W2125492065 hasConceptScore W2125492065C86803240 @default.
- W2125492065 hasIssue "4" @default.
- W2125492065 hasLocation W21254920651 @default.
- W2125492065 hasLocation W21254920652 @default.
- W2125492065 hasOpenAccess W2125492065 @default.
- W2125492065 hasPrimaryLocation W21254920651 @default.
- W2125492065 hasRelatedWork W1499339123 @default.
- W2125492065 hasRelatedWork W1975859778 @default.
- W2125492065 hasRelatedWork W2042520059 @default.
- W2125492065 hasRelatedWork W2404664256 @default.
- W2125492065 hasRelatedWork W2467622083 @default.
- W2125492065 hasRelatedWork W2762132287 @default.
- W2125492065 hasRelatedWork W2772993264 @default.
- W2125492065 hasRelatedWork W2792929645 @default.
- W2125492065 hasRelatedWork W2898863104 @default.
- W2125492065 hasRelatedWork W3173207637 @default.
- W2125492065 hasVolume "22" @default.
- W2125492065 isParatext "false" @default.
- W2125492065 isRetracted "false" @default.
- W2125492065 magId "2125492065" @default.
- W2125492065 workType "article" @default.