Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125508603> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2125508603 endingPage "888" @default.
- W2125508603 startingPage "882" @default.
- W2125508603 abstract "Using-gene-specific radiolabeled probe DNAs, we analyzed 42 clinical bacterial isolates with high-level trimethoprim (Tp) resistance for the presence of a type I or a type II plasmid-specified dihydrofolate reductase (DHFR) gene. Plasmid DNA from 17 strains harbored a type I DHFR, whereas 11 isolates contained plasmids that harbored a type II DHFR structural gene. The plasmid DNAs from five strains appeared to hybridize with both type I and type II DHFR probe DNAs. In addition, eight isolates had type I resistance determinants integrated into the chromosomes, presumably on transposon 7 (Tn7). Among the strains analyzed in this survey, none of the chromosomally located, Tp-insensitive reductases were of the type II class. Both the plasmid and chromosomal DNAs of one isolate showed no homology with either the type I or type II DHFR probe DNA. The plasmid harbored by this strain encoded a new Tp-resistant enzyme that differed significantly, both in molecular weight and with respect to trimethoprim and methotrexate inhibition kinetics, from the previously characterized plasmid-associated dihydrofolate reductases." @default.
- W2125508603 created "2016-06-24" @default.
- W2125508603 creator A5002929250 @default.
- W2125508603 creator A5020092198 @default.
- W2125508603 creator A5077692835 @default.
- W2125508603 date "1982-11-01" @default.
- W2125508603 modified "2023-10-12" @default.
- W2125508603 title "Monitoring of plasmid-encoded, trimethoprim-resistant dihydrofolate reductase genes: detection of a new resistant enzyme" @default.
- W2125508603 cites W1586821206 @default.
- W2125508603 cites W1888433954 @default.
- W2125508603 cites W1912451872 @default.
- W2125508603 cites W1969212211 @default.
- W2125508603 cites W1973403101 @default.
- W2125508603 cites W2017165782 @default.
- W2125508603 cites W2019410656 @default.
- W2125508603 cites W2021099322 @default.
- W2125508603 cites W2028082957 @default.
- W2125508603 cites W2039416580 @default.
- W2125508603 cites W2040276985 @default.
- W2125508603 cites W2058897750 @default.
- W2125508603 cites W2059522972 @default.
- W2125508603 cites W2078734721 @default.
- W2125508603 cites W2108189997 @default.
- W2125508603 cites W2141589065 @default.
- W2125508603 cites W2164544751 @default.
- W2125508603 cites W2322275362 @default.
- W2125508603 cites W4229834768 @default.
- W2125508603 doi "https://doi.org/10.1128/aac.22.5.882" @default.
- W2125508603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/185675" @default.
- W2125508603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7181492" @default.
- W2125508603 hasPublicationYear "1982" @default.
- W2125508603 type Work @default.
- W2125508603 sameAs 2125508603 @default.
- W2125508603 citedByCount "73" @default.
- W2125508603 countsByYear W21255086032012 @default.
- W2125508603 crossrefType "journal-article" @default.
- W2125508603 hasAuthorship W2125508603A5002929250 @default.
- W2125508603 hasAuthorship W2125508603A5020092198 @default.
- W2125508603 hasAuthorship W2125508603A5077692835 @default.
- W2125508603 hasBestOaLocation W21255086031 @default.
- W2125508603 hasConcept C104317684 @default.
- W2125508603 hasConcept C143065580 @default.
- W2125508603 hasConcept C153911025 @default.
- W2125508603 hasConcept C22744801 @default.
- W2125508603 hasConcept C2781320022 @default.
- W2125508603 hasConcept C4918238 @default.
- W2125508603 hasConcept C54355233 @default.
- W2125508603 hasConcept C552990157 @default.
- W2125508603 hasConcept C86803240 @default.
- W2125508603 hasConcept C89423630 @default.
- W2125508603 hasConceptScore W2125508603C104317684 @default.
- W2125508603 hasConceptScore W2125508603C143065580 @default.
- W2125508603 hasConceptScore W2125508603C153911025 @default.
- W2125508603 hasConceptScore W2125508603C22744801 @default.
- W2125508603 hasConceptScore W2125508603C2781320022 @default.
- W2125508603 hasConceptScore W2125508603C4918238 @default.
- W2125508603 hasConceptScore W2125508603C54355233 @default.
- W2125508603 hasConceptScore W2125508603C552990157 @default.
- W2125508603 hasConceptScore W2125508603C86803240 @default.
- W2125508603 hasConceptScore W2125508603C89423630 @default.
- W2125508603 hasIssue "5" @default.
- W2125508603 hasLocation W21255086031 @default.
- W2125508603 hasLocation W21255086032 @default.
- W2125508603 hasLocation W21255086033 @default.
- W2125508603 hasOpenAccess W2125508603 @default.
- W2125508603 hasPrimaryLocation W21255086031 @default.
- W2125508603 hasRelatedWork W1571771606 @default.
- W2125508603 hasRelatedWork W1927614236 @default.
- W2125508603 hasRelatedWork W2026612772 @default.
- W2125508603 hasRelatedWork W2068877757 @default.
- W2125508603 hasRelatedWork W2133665463 @default.
- W2125508603 hasRelatedWork W2164636227 @default.
- W2125508603 hasRelatedWork W2524850911 @default.
- W2125508603 hasRelatedWork W2620737981 @default.
- W2125508603 hasRelatedWork W4220995072 @default.
- W2125508603 hasRelatedWork W2189446075 @default.
- W2125508603 hasVolume "22" @default.
- W2125508603 isParatext "false" @default.
- W2125508603 isRetracted "false" @default.
- W2125508603 magId "2125508603" @default.
- W2125508603 workType "article" @default.