FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125508721> ?p ?o ?g. }

• W2125508721 endingPage "836" @default.
• W2125508721 startingPage "827" @default.
• W2125508721 abstract "Sex chromosome inactivation is essential epigenetic programming in male germ cells. However, it remains largely unclear how epigenetic silencing of sex chromosomes impacts the evolution of the mammalian genome. Here we demonstrate that male sex chromosome inactivation is highly conserved between humans and mice and has an impact on the genetic evolution of human sex chromosomes. We show that, in humans, sex chromosome inactivation established during meiosis is maintained into spermatids with the silent compartment postmeiotic sex chromatin (PMSC). Human PMSC is illuminated with epigenetic modifications such as trimethylated lysine 9 of histone H3 and heterochromatin proteins CBX1 and CBX3, which implicate a conserved mechanism underlying the maintenance of sex chromosome inactivation in mammals. Furthermore, our analyses suggest that male sex chromosome inactivation has impacted multiple aspects of the evolutionary history of mammalian sex chromosomes: amplification of copy number, retrotranspositions, acquisition of de novo genes, and acquisition of different expression profiles. Most strikingly, profiles of escape genes from postmeiotic silencing diverge significantly between humans and mice. Escape genes exhibit higher rates of amino acid changes compared with non-escape genes, suggesting that they are beneficial for reproductive fitness and may allow mammals to cope with conserved postmeiotic silencing during the evolutionary past. Taken together, we propose that the epigenetic silencing mechanism impacts the genetic evolution of sex chromosomes and contributed to speciation and reproductive diversity in mammals." @default.
• W2125508721 created "2016-06-24" @default.
• W2125508721 creator A5016299831 @default.
• W2125508721 creator A5028700572 @default.
• W2125508721 creator A5029317187 @default.
• W2125508721 creator A5034615300 @default.
• W2125508721 creator A5065911499 @default.
• W2125508721 date "2012-02-28" @default.
• W2125508721 modified "2023-10-16" @default.
• W2125508721 title "Human postmeiotic sex chromatin and its impact on sex chromosome evolution" @default.
• W2125508721 cites W1965113140 @default.
• W2125508721 cites W1966170126 @default.
• W2125508721 cites W1984571992 @default.
• W2125508721 cites W1985594917 @default.
• W2125508721 cites W1985658425 @default.
• W2125508721 cites W1999584441 @default.
• W2125508721 cites W2000945483 @default.
• W2125508721 cites W2003935644 @default.
• W2125508721 cites W2007074774 @default.
• W2125508721 cites W2020958409 @default.
• W2125508721 cites W2022651039 @default.
• W2125508721 cites W2024754608 @default.
• W2125508721 cites W2031416354 @default.
• W2125508721 cites W2035000127 @default.
• W2125508721 cites W2036666081 @default.
• W2125508721 cites W2042661483 @default.
• W2125508721 cites W2050305024 @default.
• W2125508721 cites W2054266967 @default.
• W2125508721 cites W2059265921 @default.
• W2125508721 cites W2059959802 @default.
• W2125508721 cites W2063535371 @default.
• W2125508721 cites W2072279410 @default.
• W2125508721 cites W2078075583 @default.
• W2125508721 cites W2079004698 @default.
• W2125508721 cites W2086152457 @default.
• W2125508721 cites W2086744446 @default.
• W2125508721 cites W2094947107 @default.
• W2125508721 cites W2106882534 @default.
• W2125508721 cites W2109183032 @default.
• W2125508721 cites W2121950969 @default.
• W2125508721 cites W2122152054 @default.
• W2125508721 cites W2126084304 @default.
• W2125508721 cites W2133894023 @default.
• W2125508721 cites W2139415415 @default.
• W2125508721 cites W2144746162 @default.
• W2125508721 cites W2147507101 @default.
• W2125508721 cites W2151548788 @default.
• W2125508721 cites W2167496283 @default.
• W2125508721 cites W2169910722 @default.
• W2125508721 cites W4236236547 @default.
• W2125508721 cites W4249939244 @default.
• W2125508721 cites W4293003414 @default.
• W2125508721 cites W431198878 @default.
• W2125508721 doi "https://doi.org/10.1101/gr.135046.111" @default.
• W2125508721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3337429" @default.
• W2125508721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22375025" @default.
• W2125508721 hasPublicationYear "2012" @default.
• W2125508721 type Work @default.
• W2125508721 sameAs 2125508721 @default.
• W2125508721 citedByCount "49" @default.
• W2125508721 countsByYear W21255087212012 @default.
• W2125508721 countsByYear W21255087212013 @default.
• W2125508721 countsByYear W21255087212014 @default.
• W2125508721 countsByYear W21255087212015 @default.
• W2125508721 countsByYear W21255087212016 @default.
• W2125508721 countsByYear W21255087212017 @default.
• W2125508721 countsByYear W21255087212018 @default.
• W2125508721 countsByYear W21255087212019 @default.
• W2125508721 countsByYear W21255087212020 @default.
• W2125508721 countsByYear W21255087212021 @default.
• W2125508721 countsByYear W21255087212022 @default.
• W2125508721 countsByYear W21255087212023 @default.
• W2125508721 crossrefType "journal-article" @default.
• W2125508721 hasAuthorship W2125508721A5016299831 @default.
• W2125508721 hasAuthorship W2125508721A5028700572 @default.
• W2125508721 hasAuthorship W2125508721A5029317187 @default.
• W2125508721 hasAuthorship W2125508721A5034615300 @default.
• W2125508721 hasAuthorship W2125508721A5065911499 @default.
• W2125508721 hasBestOaLocation W21255087211 @default.
• W2125508721 hasConcept C103435993 @default.
• W2125508721 hasConcept C104317684 @default.
• W2125508721 hasConcept C2780246931 @default.
• W2125508721 hasConcept C30481170 @default.
• W2125508721 hasConcept C35158069 @default.
• W2125508721 hasConcept C41091548 @default.
• W2125508721 hasConcept C4323932 @default.
• W2125508721 hasConcept C54355233 @default.
• W2125508721 hasConcept C64927066 @default.
• W2125508721 hasConcept C83640560 @default.
• W2125508721 hasConcept C86803240 @default.
• W2125508721 hasConcept C92509807 @default.
• W2125508721 hasConceptScore W2125508721C103435993 @default.
• W2125508721 hasConceptScore W2125508721C104317684 @default.
• W2125508721 hasConceptScore W2125508721C2780246931 @default.
• W2125508721 hasConceptScore W2125508721C30481170 @default.
• W2125508721 hasConceptScore W2125508721C35158069 @default.
• W2125508721 hasConceptScore W2125508721C41091548 @default.
• W2125508721 hasConceptScore W2125508721C4323932 @default.

• next