Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125508726> ?p ?o ?g. }
- W2125508726 endingPage "350" @default.
- W2125508726 startingPage "343" @default.
- W2125508726 abstract "To facilitate the development of assays for the discovery of pharmaceuticals capable of mimicking the effects of caloric restriction (CR) on life- and healthspan (CR mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer chemopreventatives in reproducing the hepatic gene expression profile produced by long-term CR (LTCR), using Affymetrix microarrays. We have shown that CR initiated late in life begins to extend lifespan, reduce cancer as a cause of death, and reproduce approximately three-quarters of the genomic effects of LTCR in 8 wk (CR8). Eight weeks of metformin treatment was superior to CR8 at reproducing LTCR-like gene expression changes, maintaining a superior number of such changes over a broad range of statistical stringencies, and producing more Gene Ontology terms overlapping those produced by LTCR. Consistent with these results, metformin has been shown to reduce cancer incidence in mice and humans. Phenformin, a chemical cousin of metformin, extends lifespan and reduces tumor incidence in mice. Taken together, these results indicate that gene expression biomarkers can be used to identify promising candidate CR mimetics." @default.
- W2125508726 created "2016-06-24" @default.
- W2125508726 creator A5035115701 @default.
- W2125508726 creator A5044859027 @default.
- W2125508726 creator A5055682712 @default.
- W2125508726 creator A5083619859 @default.
- W2125508726 date "2005-11-17" @default.
- W2125508726 modified "2023-09-25" @default.
- W2125508726 title "Identification of potential caloric restriction mimetics by microarray profiling" @default.
- W2125508726 cites W1523543948 @default.
- W2125508726 cites W1862276185 @default.
- W2125508726 cites W1954602768 @default.
- W2125508726 cites W1969809609 @default.
- W2125508726 cites W1984900991 @default.
- W2125508726 cites W1994357518 @default.
- W2125508726 cites W1999524627 @default.
- W2125508726 cites W2016021819 @default.
- W2125508726 cites W2016797892 @default.
- W2125508726 cites W2019574577 @default.
- W2125508726 cites W2021239799 @default.
- W2125508726 cites W2022871709 @default.
- W2125508726 cites W2026511467 @default.
- W2125508726 cites W2026967508 @default.
- W2125508726 cites W2027423883 @default.
- W2125508726 cites W2029336414 @default.
- W2125508726 cites W2030031350 @default.
- W2125508726 cites W2034022260 @default.
- W2125508726 cites W2037663210 @default.
- W2125508726 cites W2046503553 @default.
- W2125508726 cites W2058737138 @default.
- W2125508726 cites W2061684121 @default.
- W2125508726 cites W2064310817 @default.
- W2125508726 cites W2065827854 @default.
- W2125508726 cites W2067691245 @default.
- W2125508726 cites W2088469990 @default.
- W2125508726 cites W2102634320 @default.
- W2125508726 cites W2104790095 @default.
- W2125508726 cites W2109972881 @default.
- W2125508726 cites W2119552718 @default.
- W2125508726 cites W2125840439 @default.
- W2125508726 cites W2130016073 @default.
- W2125508726 cites W2131989143 @default.
- W2125508726 cites W2136067890 @default.
- W2125508726 cites W2137720344 @default.
- W2125508726 cites W2150926065 @default.
- W2125508726 cites W2159401204 @default.
- W2125508726 cites W2159620999 @default.
- W2125508726 cites W2161703012 @default.
- W2125508726 cites W2165764675 @default.
- W2125508726 cites W2166377569 @default.
- W2125508726 cites W4252684946 @default.
- W2125508726 cites W4294107304 @default.
- W2125508726 doi "https://doi.org/10.1152/physiolgenomics.00069.2005" @default.
- W2125508726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16189280" @default.
- W2125508726 hasPublicationYear "2005" @default.
- W2125508726 type Work @default.
- W2125508726 sameAs 2125508726 @default.
- W2125508726 citedByCount "151" @default.
- W2125508726 countsByYear W21255087262012 @default.
- W2125508726 countsByYear W21255087262013 @default.
- W2125508726 countsByYear W21255087262014 @default.
- W2125508726 countsByYear W21255087262015 @default.
- W2125508726 countsByYear W21255087262016 @default.
- W2125508726 countsByYear W21255087262017 @default.
- W2125508726 countsByYear W21255087262018 @default.
- W2125508726 countsByYear W21255087262019 @default.
- W2125508726 countsByYear W21255087262020 @default.
- W2125508726 countsByYear W21255087262021 @default.
- W2125508726 countsByYear W21255087262022 @default.
- W2125508726 countsByYear W21255087262023 @default.
- W2125508726 crossrefType "journal-article" @default.
- W2125508726 hasAuthorship W2125508726A5035115701 @default.
- W2125508726 hasAuthorship W2125508726A5044859027 @default.
- W2125508726 hasAuthorship W2125508726A5055682712 @default.
- W2125508726 hasAuthorship W2125508726A5083619859 @default.
- W2125508726 hasBestOaLocation W21255087262 @default.
- W2125508726 hasConcept C104317684 @default.
- W2125508726 hasConcept C121608353 @default.
- W2125508726 hasConcept C134018914 @default.
- W2125508726 hasConcept C150194340 @default.
- W2125508726 hasConcept C18431079 @default.
- W2125508726 hasConcept C186836561 @default.
- W2125508726 hasConcept C193244246 @default.
- W2125508726 hasConcept C20032557 @default.
- W2125508726 hasConcept C2778877718 @default.
- W2125508726 hasConcept C2780323712 @default.
- W2125508726 hasConcept C54355233 @default.
- W2125508726 hasConcept C555293320 @default.
- W2125508726 hasConcept C60644358 @default.
- W2125508726 hasConcept C70721500 @default.
- W2125508726 hasConcept C8415881 @default.
- W2125508726 hasConcept C86803240 @default.
- W2125508726 hasConcept C95371953 @default.
- W2125508726 hasConceptScore W2125508726C104317684 @default.
- W2125508726 hasConceptScore W2125508726C121608353 @default.
- W2125508726 hasConceptScore W2125508726C134018914 @default.
- W2125508726 hasConceptScore W2125508726C150194340 @default.
- W2125508726 hasConceptScore W2125508726C18431079 @default.