FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125557421> ?p ?o ?g. }

• W2125557421 abstract "BackgroundResistance to anti-malarials is a major public health problem worldwide. After deployment of artemisinin-based combination therapy (ACT) there have been reports of reduced sensitivity to ACT by malaria parasites in South-East Asia. In Tanzania, artemether-lumefantrine (ALu) is the recommended first-line drug in treatment of uncomplicated malaria. This study surveyed the distribution of the Plasmodium falciparum multidrug resistance protein-1 single nucleotide polymorphisms (SNPs) associated with increased parasite tolerance to ALu, in Tanzania.MethodsA total of 687 Plasmodium falciparum positive dried blood spots on filter paper and rapid diagnostic test strips collected by finger pricks from patients attending health facilities in six regions of Tanzania mainland between June 2010 and August 2011 were used. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect Pfmdr1 SNPs N86Y, Y184F and D1246Y.ResultsThere were variations in the distribution of Pfmdr1 polymorphisms among regions. Tanga region had exceptionally high prevalence of mutant alleles, while Mbeya had the highest prevalence of wild type alleles. The haplotype YFY was exclusively most prevalent in Tanga (29.6%) whereas the NYD haplotype was the most prevalent in all other regions. Excluding Tanga and Mbeya, four, most common Pfmdr1 haplotypes did not vary between the remaining four regions (χ2 = 2.3, p = 0.512). The NFD haplotype was the second most prevalent haplotype in all regions, ranging from 17% - 26%.ConclusionThis is the first country-wide survey on Pfmdr1 mutations associated with ACT resistance. Distribution of individual Pfmdr1 mutations at codons 86, 184 and 1246 varies throughout Tanzanian regions. There is a general homogeneity in distribution of common Pfmdr1 haplotypes reflecting strict implementation of ALu policy in Tanzania with overall prevalence of NFD haplotype ranging from 17 to 26% among other haplotypes. With continuation of ALu as first-line drug this haplotype is expected to keep rising, thus there is need for continued pharmacovigilance studies to monitor any delayed parasite clearance by the drug." @default.
• W2125557421 created "2016-06-24" @default.
• W2125557421 creator A5000029644 @default.
• W2125557421 creator A5043664889 @default.
• W2125557421 creator A5053632621 @default.
• W2125557421 creator A5058311625 @default.
• W2125557421 creator A5060933725 @default.
• W2125557421 creator A5061085684 @default.
• W2125557421 creator A5075636609 @default.
• W2125557421 creator A5085522877 @default.
• W2125557421 date "2014-07-09" @default.
• W2125557421 modified "2023-10-15" @default.
• W2125557421 title "Surveillance of artemether-lumefantrine associated Plasmodium falciparum multidrug resistance protein-1 gene polymorphisms in Tanzania" @default.
• W2125557421 cites W1865107143 @default.
• W2125557421 cites W1970334162 @default.
• W2125557421 cites W1972177048 @default.
• W2125557421 cites W1974064030 @default.
• W2125557421 cites W1996551849 @default.
• W2125557421 cites W1999748946 @default.
• W2125557421 cites W2019358007 @default.
• W2125557421 cites W2048102298 @default.
• W2125557421 cites W2061649602 @default.
• W2125557421 cites W2073059379 @default.
• W2125557421 cites W2090693309 @default.
• W2125557421 cites W2090888322 @default.
• W2125557421 cites W2094821899 @default.
• W2125557421 cites W2096071938 @default.
• W2125557421 cites W2099330256 @default.
• W2125557421 cites W2104536143 @default.
• W2125557421 cites W2107362807 @default.
• W2125557421 cites W2118266103 @default.
• W2125557421 cites W2123889383 @default.
• W2125557421 cites W2124634096 @default.
• W2125557421 cites W2126626383 @default.
• W2125557421 cites W2131902613 @default.
• W2125557421 cites W2132831164 @default.
• W2125557421 cites W2133121894 @default.
• W2125557421 cites W2142060065 @default.
• W2125557421 cites W2143609748 @default.
• W2125557421 cites W2150269854 @default.
• W2125557421 cites W2155001170 @default.
• W2125557421 cites W2155737651 @default.
• W2125557421 cites W2157068434 @default.
• W2125557421 cites W2157783963 @default.
• W2125557421 cites W2160778580 @default.
• W2125557421 cites W2164272027 @default.
• W2125557421 cites W2166347927 @default.
• W2125557421 cites W2167153421 @default.
• W2125557421 cites W2167982945 @default.
• W2125557421 cites W2169626723 @default.
• W2125557421 cites W2170571116 @default.
• W2125557421 doi "https://doi.org/10.1186/1475-2875-13-264" @default.
• W2125557421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4099215" @default.
• W2125557421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25007802" @default.
• W2125557421 hasPublicationYear "2014" @default.
• W2125557421 type Work @default.
• W2125557421 sameAs 2125557421 @default.
• W2125557421 citedByCount "28" @default.
• W2125557421 countsByYear W21255574212015 @default.
• W2125557421 countsByYear W21255574212016 @default.
• W2125557421 countsByYear W21255574212017 @default.
• W2125557421 countsByYear W21255574212018 @default.
• W2125557421 countsByYear W21255574212019 @default.
• W2125557421 countsByYear W21255574212020 @default.
• W2125557421 countsByYear W21255574212021 @default.
• W2125557421 countsByYear W21255574212022 @default.
• W2125557421 countsByYear W21255574212023 @default.
• W2125557421 crossrefType "journal-article" @default.
• W2125557421 hasAuthorship W2125557421A5000029644 @default.
• W2125557421 hasAuthorship W2125557421A5043664889 @default.
• W2125557421 hasAuthorship W2125557421A5053632621 @default.
• W2125557421 hasAuthorship W2125557421A5058311625 @default.
• W2125557421 hasAuthorship W2125557421A5060933725 @default.
• W2125557421 hasAuthorship W2125557421A5061085684 @default.
• W2125557421 hasAuthorship W2125557421A5075636609 @default.
• W2125557421 hasAuthorship W2125557421A5085522877 @default.
• W2125557421 hasBestOaLocation W21255574211 @default.
• W2125557421 hasConcept C104317684 @default.
• W2125557421 hasConcept C114851261 @default.
• W2125557421 hasConcept C135763542 @default.
• W2125557421 hasConcept C153209595 @default.
• W2125557421 hasConcept C159047783 @default.
• W2125557421 hasConcept C197754878 @default.
• W2125557421 hasConcept C203014093 @default.
• W2125557421 hasConcept C2776120307 @default.
• W2125557421 hasConcept C2778048844 @default.
• W2125557421 hasConcept C2778371730 @default.
• W2125557421 hasConcept C2778629330 @default.
• W2125557421 hasConcept C2779357621 @default.
• W2125557421 hasConcept C2780780316 @default.
• W2125557421 hasConcept C39432304 @default.
• W2125557421 hasConcept C54355233 @default.
• W2125557421 hasConcept C86803240 @default.
• W2125557421 hasConcept C91375879 @default.
• W2125557421 hasConceptScore W2125557421C104317684 @default.
• W2125557421 hasConceptScore W2125557421C114851261 @default.
• W2125557421 hasConceptScore W2125557421C135763542 @default.
• W2125557421 hasConceptScore W2125557421C153209595 @default.
• W2125557421 hasConceptScore W2125557421C159047783 @default.
• W2125557421 hasConceptScore W2125557421C197754878 @default.

• next