Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125591567> ?p ?o ?g. }
- W2125591567 endingPage "569" @default.
- W2125591567 startingPage "560" @default.
- W2125591567 abstract "Abstract Amelogenin is a proline‐rich enamel matrix protein known to play an important role in the oriented growth of enamel crystals. Amelogenin self‐assembles to form nanospheres and higher order structures mediated by hydrophobic interactions. This study aims to obtain a better insight into the relationship between primary–secondary structure and self‐assembly of amelogenin by applying computational and biophysical methods. Variable temperature circular dichroism studies indicated that under physiological pH recombinant full‐length porcine amelogenin contains unordered structures in equilibrium with polyproline type II (PPII) structure, the latter being more populated at lower temperatures. Increasing the concentration of rP172 resulted in the promotion of folding to an ordered β‐structured assembly. Isothermal titration calorimetry dilution studies revealed that at all temperatures, self‐assembly is entropically driven due to the hydrophobic effect and the molar heat of assembly (Δ H A ) decreases with temperature. Using a computational approach, a profile of domains in the amino acid sequence that have a high propensity to assemble and to have PPII structures has been identified. We conclude that the assembly properties of amelogenin are due to complementarity between the hydrophobic and PPII helix prone regions. Proteins 2009. © 2009 Wiley‐Liss, Inc." @default.
- W2125591567 created "2016-06-24" @default.
- W2125591567 creator A5011247115 @default.
- W2125591567 creator A5035157534 @default.
- W2125591567 creator A5043108596 @default.
- W2125591567 creator A5048533649 @default.
- W2125591567 creator A5052660758 @default.
- W2125591567 creator A5076682461 @default.
- W2125591567 date "2009-03-09" @default.
- W2125591567 modified "2023-10-16" @default.
- W2125591567 title "Analysis of secondary structure and self‐assembly of amelogenin by variable temperature circular dichroism and isothermal titration calorimetry" @default.
- W2125591567 cites W1567588704 @default.
- W2125591567 cites W1575285231 @default.
- W2125591567 cites W1580609715 @default.
- W2125591567 cites W1599226649 @default.
- W2125591567 cites W1968826334 @default.
- W2125591567 cites W1969674072 @default.
- W2125591567 cites W1971883721 @default.
- W2125591567 cites W1973117210 @default.
- W2125591567 cites W1973680007 @default.
- W2125591567 cites W1973783994 @default.
- W2125591567 cites W1974525618 @default.
- W2125591567 cites W1980015132 @default.
- W2125591567 cites W1985557818 @default.
- W2125591567 cites W1989142184 @default.
- W2125591567 cites W1989497655 @default.
- W2125591567 cites W1991865349 @default.
- W2125591567 cites W1993294667 @default.
- W2125591567 cites W1994003100 @default.
- W2125591567 cites W1996565611 @default.
- W2125591567 cites W1999636937 @default.
- W2125591567 cites W2002147692 @default.
- W2125591567 cites W2006518478 @default.
- W2125591567 cites W2011269963 @default.
- W2125591567 cites W2011713122 @default.
- W2125591567 cites W2012850328 @default.
- W2125591567 cites W2013491063 @default.
- W2125591567 cites W2013846682 @default.
- W2125591567 cites W2020636038 @default.
- W2125591567 cites W2030402135 @default.
- W2125591567 cites W2032503452 @default.
- W2125591567 cites W2033029484 @default.
- W2125591567 cites W2045840023 @default.
- W2125591567 cites W2049597709 @default.
- W2125591567 cites W2050446363 @default.
- W2125591567 cites W2053399901 @default.
- W2125591567 cites W2053453730 @default.
- W2125591567 cites W2061693144 @default.
- W2125591567 cites W2063573575 @default.
- W2125591567 cites W2065783449 @default.
- W2125591567 cites W2066342320 @default.
- W2125591567 cites W2067620247 @default.
- W2125591567 cites W2068521700 @default.
- W2125591567 cites W2082111171 @default.
- W2125591567 cites W2091813526 @default.
- W2125591567 cites W2094639753 @default.
- W2125591567 cites W2099385195 @default.
- W2125591567 cites W2109567227 @default.
- W2125591567 cites W2118011341 @default.
- W2125591567 cites W2124617054 @default.
- W2125591567 cites W2128547681 @default.
- W2125591567 cites W2132620042 @default.
- W2125591567 cites W2133245471 @default.
- W2125591567 cites W2133902722 @default.
- W2125591567 cites W2134373577 @default.
- W2125591567 cites W2143234288 @default.
- W2125591567 cites W2149472608 @default.
- W2125591567 cites W2153959417 @default.
- W2125591567 cites W2161763549 @default.
- W2125591567 cites W2163540881 @default.
- W2125591567 cites W2166926540 @default.
- W2125591567 doi "https://doi.org/10.1002/prot.22369" @default.
- W2125591567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2748104" @default.
- W2125591567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19274734" @default.
- W2125591567 hasPublicationYear "2009" @default.
- W2125591567 type Work @default.
- W2125591567 sameAs 2125591567 @default.
- W2125591567 citedByCount "48" @default.
- W2125591567 countsByYear W21255915672012 @default.
- W2125591567 countsByYear W21255915672013 @default.
- W2125591567 countsByYear W21255915672014 @default.
- W2125591567 countsByYear W21255915672015 @default.
- W2125591567 countsByYear W21255915672016 @default.
- W2125591567 countsByYear W21255915672017 @default.
- W2125591567 countsByYear W21255915672018 @default.
- W2125591567 countsByYear W21255915672020 @default.
- W2125591567 countsByYear W21255915672021 @default.
- W2125591567 countsByYear W21255915672022 @default.
- W2125591567 countsByYear W21255915672023 @default.
- W2125591567 crossrefType "journal-article" @default.
- W2125591567 hasAuthorship W2125591567A5011247115 @default.
- W2125591567 hasAuthorship W2125591567A5035157534 @default.
- W2125591567 hasAuthorship W2125591567A5043108596 @default.
- W2125591567 hasAuthorship W2125591567A5048533649 @default.
- W2125591567 hasAuthorship W2125591567A5052660758 @default.
- W2125591567 hasAuthorship W2125591567A5076682461 @default.
- W2125591567 hasBestOaLocation W21255915672 @default.
- W2125591567 hasConcept C104317684 @default.