Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125599443> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2125599443 endingPage "1018" @default.
- W2125599443 startingPage "1013" @default.
- W2125599443 abstract "Abstract Conditionally replicative adenoviruses (CRAd) are under investigation as anticancer agents. Previously, we found that the CRAd AdΔ24-p53, expressing the p53 tumor suppressor protein from its genome, more effectively killed most human cancer cells than did its parent AdΔ24. However, a minority of cancer cell lines poorly responded to the oncolysis-enhancing effect of p53. Here we show that refractory cell lines expressed high levels of the major negative p53 regulator murine double minute 2 (MDM2). To obviate MDM2-mediated inactivation of CRAd-encoded p53, we constructed the new CRAd AdΔ24-p53(14/19) encoding a p53 variant incapable of binding to MDM2. AdΔ24-p53(14/19) was ∼10 times more effective than AdΔ24-p53 in killing cancer cell lines with high levels of human MDM2, but not cells with low MDM2. This finding supports the notion that exogenous expression of functional p53 augments the anticancer efficacy of CRAds. In addition, it confirms that high MDM2 expression is a molecular determinant of resistance against oncolysis enhancement by exogenous wild-type p53. Moreover, it shows that efficacy enhancement by restoration of functional p53 can also be accomplished in cancer cells expressing a p53 inhibitor. This further expands the utility of CRAds expressing functional p53 variants for effective virotherapy of cancer and thus their possible contribution to the advancement of individualized molecular medicine." @default.
- W2125599443 created "2016-06-24" @default.
- W2125599443 creator A5007454863 @default.
- W2125599443 creator A5031464170 @default.
- W2125599443 creator A5039709555 @default.
- W2125599443 date "2005-06-01" @default.
- W2125599443 modified "2023-09-26" @default.
- W2125599443 title "Conditionally replicative adenovirus expressing degradation-resistant p53 for enhanced oncolysis of human cancer cells overexpressing murine double minute 2" @default.
- W2125599443 cites W100225602 @default.
- W2125599443 cites W1544229812 @default.
- W2125599443 cites W1965173366 @default.
- W2125599443 cites W1987536971 @default.
- W2125599443 cites W1996040472 @default.
- W2125599443 cites W1999160447 @default.
- W2125599443 cites W2000467533 @default.
- W2125599443 cites W2015519364 @default.
- W2125599443 cites W2024311042 @default.
- W2125599443 cites W2024894759 @default.
- W2125599443 cites W2030834391 @default.
- W2125599443 cites W2039382131 @default.
- W2125599443 cites W2054322190 @default.
- W2125599443 cites W2056530510 @default.
- W2125599443 cites W2060972565 @default.
- W2125599443 cites W2082979850 @default.
- W2125599443 cites W2091151265 @default.
- W2125599443 cites W2097447643 @default.
- W2125599443 cites W2099907467 @default.
- W2125599443 cites W2112242228 @default.
- W2125599443 cites W2114103020 @default.
- W2125599443 cites W2126397856 @default.
- W2125599443 cites W2155689416 @default.
- W2125599443 cites W2166213130 @default.
- W2125599443 cites W2315170386 @default.
- W2125599443 cites W4233157485 @default.
- W2125599443 doi "https://doi.org/10.1158/1535-7163.mct-05-0010" @default.
- W2125599443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15956259" @default.
- W2125599443 hasPublicationYear "2005" @default.
- W2125599443 type Work @default.
- W2125599443 sameAs 2125599443 @default.
- W2125599443 citedByCount "24" @default.
- W2125599443 countsByYear W21255994432013 @default.
- W2125599443 countsByYear W21255994432014 @default.
- W2125599443 countsByYear W21255994432017 @default.
- W2125599443 countsByYear W21255994432018 @default.
- W2125599443 countsByYear W21255994432019 @default.
- W2125599443 countsByYear W21255994432020 @default.
- W2125599443 countsByYear W21255994432021 @default.
- W2125599443 countsByYear W21255994432022 @default.
- W2125599443 crossrefType "journal-article" @default.
- W2125599443 hasAuthorship W2125599443A5007454863 @default.
- W2125599443 hasAuthorship W2125599443A5031464170 @default.
- W2125599443 hasAuthorship W2125599443A5039709555 @default.
- W2125599443 hasBestOaLocation W21255994431 @default.
- W2125599443 hasConcept C121608353 @default.
- W2125599443 hasConcept C159047783 @default.
- W2125599443 hasConcept C2776192174 @default.
- W2125599443 hasConcept C3020616263 @default.
- W2125599443 hasConcept C49744831 @default.
- W2125599443 hasConcept C502942594 @default.
- W2125599443 hasConcept C54355233 @default.
- W2125599443 hasConcept C81885089 @default.
- W2125599443 hasConcept C82210918 @default.
- W2125599443 hasConcept C86803240 @default.
- W2125599443 hasConcept C96232424 @default.
- W2125599443 hasConceptScore W2125599443C121608353 @default.
- W2125599443 hasConceptScore W2125599443C159047783 @default.
- W2125599443 hasConceptScore W2125599443C2776192174 @default.
- W2125599443 hasConceptScore W2125599443C3020616263 @default.
- W2125599443 hasConceptScore W2125599443C49744831 @default.
- W2125599443 hasConceptScore W2125599443C502942594 @default.
- W2125599443 hasConceptScore W2125599443C54355233 @default.
- W2125599443 hasConceptScore W2125599443C81885089 @default.
- W2125599443 hasConceptScore W2125599443C82210918 @default.
- W2125599443 hasConceptScore W2125599443C86803240 @default.
- W2125599443 hasConceptScore W2125599443C96232424 @default.
- W2125599443 hasIssue "6" @default.
- W2125599443 hasLocation W21255994431 @default.
- W2125599443 hasLocation W21255994432 @default.
- W2125599443 hasOpenAccess W2125599443 @default.
- W2125599443 hasPrimaryLocation W21255994431 @default.
- W2125599443 hasRelatedWork W1983046009 @default.
- W2125599443 hasRelatedWork W2039831278 @default.
- W2125599443 hasRelatedWork W2125599443 @default.
- W2125599443 hasRelatedWork W2133900718 @default.
- W2125599443 hasRelatedWork W2777660397 @default.
- W2125599443 hasRelatedWork W2778063981 @default.
- W2125599443 hasRelatedWork W2807847969 @default.
- W2125599443 hasRelatedWork W3166852946 @default.
- W2125599443 hasRelatedWork W4310787482 @default.
- W2125599443 hasRelatedWork W1963724055 @default.
- W2125599443 hasVolume "4" @default.
- W2125599443 isParatext "false" @default.
- W2125599443 isRetracted "false" @default.
- W2125599443 magId "2125599443" @default.
- W2125599443 workType "article" @default.