Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125616920> ?p ?o ?g. }
- W2125616920 endingPage "37" @default.
- W2125616920 startingPage "31" @default.
- W2125616920 abstract "Escape mutants of tick-borne encephalitis (TBE) virus were selected using neutralizing monoclonal antibodies (MAbs) that react with three different and previously unrecognized epitopes in the envelope protein E of TBE virus. Two of these variants (V-IC3 and V-IE3) exhibited a significantly reduced reactivity with their selecting MAbs, as determined by ELISA, whereas with one variant (V-IO3), reactivity was completely unchanged. Comparative sequence analyses demonstrated that each of the variants differed from the wild-type virus by a single amino acid substitution located at exposed positions within domains I, II and III of protein E. In the mouse model, all three mutants were still neurovirulent but exhibited a significantly reduced neuroinvasiveness after subcutaneous inoculation. Virus replication, however, was sufficient to induce a specific antibody response. The observed alterations in virulence properties were not associated with reduced growth rates in vertebrate cell cultures, but one variant (V-IE3) exhibited a small plaque phenotype. The mutation of variant V-IO3 resulted in a temperature-sensitive phenotype and a significant elevation of the pH-threshold of the conformational change necessary for fusion activity." @default.
- W2125616920 created "2016-06-24" @default.
- W2125616920 creator A5025031837 @default.
- W2125616920 creator A5032876551 @default.
- W2125616920 creator A5074787867 @default.
- W2125616920 creator A5080446878 @default.
- W2125616920 creator A5083400255 @default.
- W2125616920 date "1997-01-01" @default.
- W2125616920 modified "2023-09-30" @default.
- W2125616920 title "Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice." @default.
- W2125616920 cites W1512465156 @default.
- W2125616920 cites W1530869660 @default.
- W2125616920 cites W1541665136 @default.
- W2125616920 cites W1557330854 @default.
- W2125616920 cites W1622190752 @default.
- W2125616920 cites W1748018096 @default.
- W2125616920 cites W1866802553 @default.
- W2125616920 cites W1886152626 @default.
- W2125616920 cites W1893665885 @default.
- W2125616920 cites W1970057644 @default.
- W2125616920 cites W1970651401 @default.
- W2125616920 cites W1973123733 @default.
- W2125616920 cites W1977873235 @default.
- W2125616920 cites W1978113142 @default.
- W2125616920 cites W1979188828 @default.
- W2125616920 cites W1984416131 @default.
- W2125616920 cites W1988763833 @default.
- W2125616920 cites W1995452398 @default.
- W2125616920 cites W1998293016 @default.
- W2125616920 cites W2000336507 @default.
- W2125616920 cites W2013818062 @default.
- W2125616920 cites W2038891761 @default.
- W2125616920 cites W2046749691 @default.
- W2125616920 cites W2048575064 @default.
- W2125616920 cites W2050563013 @default.
- W2125616920 cites W2062828687 @default.
- W2125616920 cites W2072897393 @default.
- W2125616920 cites W2077779033 @default.
- W2125616920 cites W2080499378 @default.
- W2125616920 cites W2080933271 @default.
- W2125616920 cites W2083345910 @default.
- W2125616920 cites W2085633705 @default.
- W2125616920 cites W2086221905 @default.
- W2125616920 cites W2094825266 @default.
- W2125616920 cites W2098985529 @default.
- W2125616920 cites W2101653009 @default.
- W2125616920 cites W2120007683 @default.
- W2125616920 cites W2122808856 @default.
- W2125616920 cites W2129296891 @default.
- W2125616920 cites W2151249029 @default.
- W2125616920 cites W2154699293 @default.
- W2125616920 cites W2169809637 @default.
- W2125616920 doi "https://doi.org/10.1099/0022-1317-78-1-31" @default.
- W2125616920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9010282" @default.
- W2125616920 hasPublicationYear "1997" @default.
- W2125616920 type Work @default.
- W2125616920 sameAs 2125616920 @default.
- W2125616920 citedByCount "93" @default.
- W2125616920 countsByYear W21256169202012 @default.
- W2125616920 countsByYear W21256169202014 @default.
- W2125616920 countsByYear W21256169202015 @default.
- W2125616920 countsByYear W21256169202016 @default.
- W2125616920 countsByYear W21256169202017 @default.
- W2125616920 countsByYear W21256169202018 @default.
- W2125616920 countsByYear W21256169202019 @default.
- W2125616920 countsByYear W21256169202020 @default.
- W2125616920 countsByYear W21256169202021 @default.
- W2125616920 countsByYear W21256169202022 @default.
- W2125616920 countsByYear W21256169202023 @default.
- W2125616920 crossrefType "journal-article" @default.
- W2125616920 hasAuthorship W2125616920A5025031837 @default.
- W2125616920 hasAuthorship W2125616920A5032876551 @default.
- W2125616920 hasAuthorship W2125616920A5074787867 @default.
- W2125616920 hasAuthorship W2125616920A5080446878 @default.
- W2125616920 hasAuthorship W2125616920A5083400255 @default.
- W2125616920 hasBestOaLocation W21256169201 @default.
- W2125616920 hasConcept C104317684 @default.
- W2125616920 hasConcept C140704245 @default.
- W2125616920 hasConcept C143065580 @default.
- W2125616920 hasConcept C159047783 @default.
- W2125616920 hasConcept C159654299 @default.
- W2125616920 hasConcept C195616568 @default.
- W2125616920 hasConcept C203014093 @default.
- W2125616920 hasConcept C2522874641 @default.
- W2125616920 hasConcept C2776281056 @default.
- W2125616920 hasConcept C2779261636 @default.
- W2125616920 hasConcept C2779404267 @default.
- W2125616920 hasConcept C2780568436 @default.
- W2125616920 hasConcept C542903549 @default.
- W2125616920 hasConcept C54355233 @default.
- W2125616920 hasConcept C83455156 @default.
- W2125616920 hasConcept C86803240 @default.
- W2125616920 hasConcept C97380033 @default.
- W2125616920 hasConceptScore W2125616920C104317684 @default.
- W2125616920 hasConceptScore W2125616920C140704245 @default.
- W2125616920 hasConceptScore W2125616920C143065580 @default.
- W2125616920 hasConceptScore W2125616920C159047783 @default.
- W2125616920 hasConceptScore W2125616920C159654299 @default.