Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125642080> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2125642080 endingPage "89" @default.
- W2125642080 startingPage "86" @default.
- W2125642080 abstract "PURPOSE:Gastrin-releasing peptide (GRP) is a 27-amino acid neuropeptide that has been identified in the cytoplasm of many neuroendocrine tumors. Gastrin releasing peptide has been labeled as an autocrine growth factor in small cell lung carcinomas. Recent work has also shown this to be true in the growth of neuroblastoma cells in vitro. The purpose of this study was to demonstrate GRP and its receptor (GRP-R) in resected human neuroblastomas and to correlate the presence or absence with other known predictors of poor prognosis.To demonstrate the presence of GRP and GRP-R mRNA, total RNA was extracted from human neuroblastoma cells. A reverse transcription-polymerase chain reaction (RT-PCR) was then performed using specific primers. The products of the RT-PCR were then confirmed to be GRP and GRP-R cDNA by Southern blot analysis. The RT-PCR products were then sequenced, and these sequences were compared with the know sequences of GRP and GRP-R DNA.N = 19. GRP and GRP-R mRNA were present in all neuroblastoma specimens. Although no correlation with other known predictors of poor prognosis existed, transcripts of four different sizes (400, 450, 500, and 950 bp) were seen in the GRP-R transcripts. The sequences of the 950 bp-sized transcript reverse transcription PCR products were identical to the known GRP-R.We conclude that gastrin releasing peptide and gastrin releasing peptide receptor mRNA are present in all human neuroblastomas. Although qualitatively it appears to lack prognostic significance, its ubiquitous nature in the tumor suggests it may be a useful target on which to base future treatment modalities." @default.
- W2125642080 created "2016-06-24" @default.
- W2125642080 creator A5001125448 @default.
- W2125642080 creator A5024907975 @default.
- W2125642080 creator A5029734472 @default.
- W2125642080 creator A5052987796 @default.
- W2125642080 creator A5080767398 @default.
- W2125642080 creator A5081251215 @default.
- W2125642080 date "2001-01-01" @default.
- W2125642080 modified "2023-09-26" @default.
- W2125642080 title "Gastrin-releasing peptide: a potential growth factor expressed in human neuroblastoma tumors" @default.
- W2125642080 cites W1967097978 @default.
- W2125642080 cites W1982186695 @default.
- W2125642080 cites W1988763385 @default.
- W2125642080 cites W2031956553 @default.
- W2125642080 cites W2047300206 @default.
- W2125642080 cites W2054425455 @default.
- W2125642080 cites W2085535415 @default.
- W2125642080 cites W2127983757 @default.
- W2125642080 cites W2157145674 @default.
- W2125642080 cites W4294216491 @default.
- W2125642080 doi "https://doi.org/10.1016/s0149-7944(00)00437-2" @default.
- W2125642080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11226544" @default.
- W2125642080 hasPublicationYear "2001" @default.
- W2125642080 type Work @default.
- W2125642080 sameAs 2125642080 @default.
- W2125642080 citedByCount "13" @default.
- W2125642080 countsByYear W21256420802012 @default.
- W2125642080 countsByYear W21256420802018 @default.
- W2125642080 countsByYear W21256420802020 @default.
- W2125642080 countsByYear W21256420802021 @default.
- W2125642080 countsByYear W21256420802023 @default.
- W2125642080 crossrefType "journal-article" @default.
- W2125642080 hasAuthorship W2125642080A5001125448 @default.
- W2125642080 hasAuthorship W2125642080A5024907975 @default.
- W2125642080 hasAuthorship W2125642080A5029734472 @default.
- W2125642080 hasAuthorship W2125642080A5052987796 @default.
- W2125642080 hasAuthorship W2125642080A5080767398 @default.
- W2125642080 hasAuthorship W2125642080A5081251215 @default.
- W2125642080 hasConcept C104317684 @default.
- W2125642080 hasConcept C105580179 @default.
- W2125642080 hasConcept C118303440 @default.
- W2125642080 hasConcept C128240485 @default.
- W2125642080 hasConcept C134018914 @default.
- W2125642080 hasConcept C153911025 @default.
- W2125642080 hasConcept C170493617 @default.
- W2125642080 hasConcept C187882448 @default.
- W2125642080 hasConcept C2776715637 @default.
- W2125642080 hasConcept C2776986829 @default.
- W2125642080 hasConcept C2776998989 @default.
- W2125642080 hasConcept C2778448772 @default.
- W2125642080 hasConcept C4692481 @default.
- W2125642080 hasConcept C49039625 @default.
- W2125642080 hasConcept C502942594 @default.
- W2125642080 hasConcept C54355233 @default.
- W2125642080 hasConcept C81885089 @default.
- W2125642080 hasConcept C86803240 @default.
- W2125642080 hasConceptScore W2125642080C104317684 @default.
- W2125642080 hasConceptScore W2125642080C105580179 @default.
- W2125642080 hasConceptScore W2125642080C118303440 @default.
- W2125642080 hasConceptScore W2125642080C128240485 @default.
- W2125642080 hasConceptScore W2125642080C134018914 @default.
- W2125642080 hasConceptScore W2125642080C153911025 @default.
- W2125642080 hasConceptScore W2125642080C170493617 @default.
- W2125642080 hasConceptScore W2125642080C187882448 @default.
- W2125642080 hasConceptScore W2125642080C2776715637 @default.
- W2125642080 hasConceptScore W2125642080C2776986829 @default.
- W2125642080 hasConceptScore W2125642080C2776998989 @default.
- W2125642080 hasConceptScore W2125642080C2778448772 @default.
- W2125642080 hasConceptScore W2125642080C4692481 @default.
- W2125642080 hasConceptScore W2125642080C49039625 @default.
- W2125642080 hasConceptScore W2125642080C502942594 @default.
- W2125642080 hasConceptScore W2125642080C54355233 @default.
- W2125642080 hasConceptScore W2125642080C81885089 @default.
- W2125642080 hasConceptScore W2125642080C86803240 @default.
- W2125642080 hasIssue "1" @default.
- W2125642080 hasLocation W21256420801 @default.
- W2125642080 hasLocation W21256420802 @default.
- W2125642080 hasOpenAccess W2125642080 @default.
- W2125642080 hasPrimaryLocation W21256420801 @default.
- W2125642080 hasRelatedWork W1967925981 @default.
- W2125642080 hasRelatedWork W1996837279 @default.
- W2125642080 hasRelatedWork W2000249325 @default.
- W2125642080 hasRelatedWork W2015758488 @default.
- W2125642080 hasRelatedWork W2017460997 @default.
- W2125642080 hasRelatedWork W2125642080 @default.
- W2125642080 hasRelatedWork W2129583422 @default.
- W2125642080 hasRelatedWork W2157145674 @default.
- W2125642080 hasRelatedWork W2335717743 @default.
- W2125642080 hasRelatedWork W3005662731 @default.
- W2125642080 hasVolume "58" @default.
- W2125642080 isParatext "false" @default.
- W2125642080 isRetracted "false" @default.
- W2125642080 magId "2125642080" @default.
- W2125642080 workType "article" @default.