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• W2125680927 endingPage "58" @default.
• W2125680927 startingPage "45" @default.
• W2125680927 abstract "Cytokinesis, which leads to the physical separation of two dividing cells, is normally restrained until after nuclear division. In Saccharomyces cerevisiae, chitin synthase 2 (Chs2), which lays down the primary septum at the mother-daughter neck, also ensures proper actomyosin ring constriction during cytokinesis. During the metaphase-to-anaphase transition, phosphorylation of Chs2 by the mitotic cyclin-dependent kinase (Cdk1) retains Chs2 at the endoplasmic reticulum (ER), thereby preventing its translocation to the neck. Upon Cdk1 inactivation at the end of mitosis, Chs2 is exported from the ER and targeted to the neck. The mechanism for triggering Chs2 ER export thus far is unknown. We show here that Chs2 ER export requires the direct reversal of the inhibitory Cdk1 phosphorylation sites by Cdc14 phosphatase, the ultimate effector of the mitotic exit network (MEN). We further show that only Cdc14 liberated by the MEN after completion of chromosome segregation, and not Cdc14 released in early anaphase by the Cdc fourteen early anaphase release pathway, triggers Chs2 ER exit. Presumably, the reduced Cdk1 activity in late mitosis further favors dephosphorylation of Chs2 by Cdc14. Thus, by requiring declining Cdk1 activity and Cdc14 nuclear release for Chs2 ER export, cells ensure that septum formation is contingent upon chromosome separation and exit from mitosis." @default.
• W2125680927 created "2016-06-24" @default.
• W2125680927 creator A5030736596 @default.
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• W2125680927 creator A5051616159 @default.
• W2125680927 creator A5057238214 @default.
• W2125680927 creator A5073432818 @default.
• W2125680927 date "2012-01-01" @default.
• W2125680927 modified "2023-10-11" @default.
• W2125680927 title "Dependence of Chs2 ER export on dephosphorylation by cytoplasmic Cdc14 ensures that septum formation follows mitosis" @default.
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• W2125680927 doi "https://doi.org/10.1091/mbc.e11-05-0434" @default.
• W2125680927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3248903" @default.
• W2125680927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22072794" @default.
• W2125680927 hasPublicationYear "2012" @default.
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