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• W2125698751 abstract "Pleomorphic dermal sarcoma (PDS) is a rare neoplasm sharing pathological features with atypical fibroxanthoma, but adding tumor necrosis, invasion beyond superficial subcutis or vascular or perineural infiltration. Although its metastatic risk has been estimated to be less than 5%, its real outcome is presently uncertain because of its rarity and to the lack of homogeneous criteria used in reported cases.Retrospective clinicopathological study of 18 cases of PDS.The lesions presented as tumors or plaques (size: 7-70 mm) on the head of elderly patients (median: 81 years), without a gender predominance. Histopathologically, they consisted of spindle cells arranged in a fascicular pattern, containing pleomorphic epithelioid and giant multinucleated cells in varying proportions, and usually exhibiting numerous mitotic figures and infiltrative tumor margins. No immunoexpression for cytokeratins, S100 protein, desmin or CD34 was observed. Necrosis and venous invasion were found in three tumors each (17%). Follow-up was available in 15 cases (median: 33 months). Three patients (20%) had local recurrences, all with incomplete primary surgical resections. Three patients (20%) developed distant metastases in the skin, regional lymph nodes and/or lungs and died from the disease.Our data suggest that PDS may be a more aggressive neoplasm than previously estimated." @default.
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• W2125698751 date "2015-09-29" @default.
• W2125698751 modified "2023-09-29" @default.
• W2125698751 title "Pleomorphic dermal sarcoma: a more aggressive neoplasm than previously estimated" @default.
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• W2125698751 doi "https://doi.org/10.1111/cup.12603" @default.
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