FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125718087> ?p ?o ?g. }

• W2125718087 endingPage "342" @default.
• W2125718087 startingPage "331" @default.
• W2125718087 abstract "Oxidized LDL (oxLDL) are cytotoxic to vascular cells, but their possible toxic action on T cells from patients with ESRD has not been evaluated. oxLDL concentrations were measured and compared in patients who were on long-term hemodialysis (HD), in patients who had ESRD and were on continuous ambulatory peritoneal dialysis, in nondialyzed patients with chronic kidney disease, and in age- and gender-matched control subjects. In parallel, the proliferative capacity of CD69+/CD4+ T cells and their rate of apoptosis, IL-2 expression, and intracellular expression of Bcl-2 and Bax were determined in vitro. The oxLDL concentrations were significantly higher in HD patients (all P = 0.001). Upon phytohemagglutinin stimulation, CD69+/CD4+ T cells from HD patients proliferated significantly less than those from the other patients' group (both P < 0.001). oxLDL but not the native LDL were led to CD69+/CD4+ T cells' program cell death in a dosage- and time-dependent manner through Fas pathway (P = 0.001). Cell surface Fas expression was followed by DNA fragmentation when CD69+/CD4+ T cells from HD patients or control subjects were cultured with oxLDL (200 microg/ml; 31 +/- 3 versus 25 +/- 3%; P = 0.001). In the presence of oxLDL, CD69+/CD4+ T cells from HD patients expressed significantly lower IL-2 levels, which strongly correlated with a decrease in the antiapoptotic Bcl-2 and conversely with an increase in the proapoptotic Bax expression. In conclusion, these data suggest that, in HD patients, exposure of activated CD4+ T cells to oxLDL leads to Fas-mediated apoptosis in association with inhibition of IL-2 expression. Subsequently, this may favor activation of mitochondria-dependent apoptotic pathways, leading to activated CD4+ T cell dysfunction." @default.
• W2125718087 created "2016-06-24" @default.
• W2125718087 creator A5007490910 @default.
• W2125718087 creator A5013756173 @default.
• W2125718087 creator A5034612906 @default.
• W2125718087 creator A5045380776 @default.
• W2125718087 date "2007-01-01" @default.
• W2125718087 modified "2023-09-26" @default.
• W2125718087 title "Oxidized Low-Density Lipoproteins Activate CD4+ T Cell Apoptosis in Patients with End-Stage Renal Disease through Fas Engagement" @default.
• W2125718087 cites W1502903705 @default.
• W2125718087 cites W1520582774 @default.
• W2125718087 cites W1779467671 @default.
• W2125718087 cites W1863992383 @default.
• W2125718087 cites W1966459656 @default.
• W2125718087 cites W1970472013 @default.
• W2125718087 cites W1971004681 @default.
• W2125718087 cites W1975558821 @default.
• W2125718087 cites W1979246990 @default.
• W2125718087 cites W1992335027 @default.
• W2125718087 cites W2002452021 @default.
• W2125718087 cites W2006183334 @default.
• W2125718087 cites W2015126659 @default.
• W2125718087 cites W2038432548 @default.
• W2125718087 cites W2050776161 @default.
• W2125718087 cites W2052370152 @default.
• W2125718087 cites W2055864845 @default.
• W2125718087 cites W2067029625 @default.
• W2125718087 cites W2077173353 @default.
• W2125718087 cites W2089832789 @default.
• W2125718087 cites W2107235183 @default.
• W2125718087 cites W2116404316 @default.
• W2125718087 cites W2129971278 @default.
• W2125718087 cites W2135503869 @default.
• W2125718087 cites W2136304861 @default.
• W2125718087 cites W2142717433 @default.
• W2125718087 cites W2161505898 @default.
• W2125718087 cites W2165726012 @default.
• W2125718087 cites W2263442792 @default.
• W2125718087 cites W2320930750 @default.
• W2125718087 cites W2334384697 @default.
• W2125718087 cites W2614361772 @default.
• W2125718087 doi "https://doi.org/10.1681/asn.2006050514" @default.
• W2125718087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17182885" @default.
• W2125718087 hasPublicationYear "2007" @default.
• W2125718087 type Work @default.
• W2125718087 sameAs 2125718087 @default.
• W2125718087 citedByCount "27" @default.
• W2125718087 countsByYear W21257180872012 @default.
• W2125718087 countsByYear W21257180872013 @default.
• W2125718087 countsByYear W21257180872014 @default.
• W2125718087 countsByYear W21257180872015 @default.
• W2125718087 countsByYear W21257180872017 @default.
• W2125718087 countsByYear W21257180872019 @default.
• W2125718087 countsByYear W21257180872020 @default.
• W2125718087 countsByYear W21257180872023 @default.
• W2125718087 crossrefType "journal-article" @default.
• W2125718087 hasAuthorship W2125718087A5007490910 @default.
• W2125718087 hasAuthorship W2125718087A5013756173 @default.
• W2125718087 hasAuthorship W2125718087A5034612906 @default.
• W2125718087 hasAuthorship W2125718087A5045380776 @default.
• W2125718087 hasBestOaLocation W21257180871 @default.
• W2125718087 hasConcept C126322002 @default.
• W2125718087 hasConcept C134018914 @default.
• W2125718087 hasConcept C154317977 @default.
• W2125718087 hasConcept C176324957 @default.
• W2125718087 hasConcept C185592680 @default.
• W2125718087 hasConcept C18903297 @default.
• W2125718087 hasConcept C190283241 @default.
• W2125718087 hasConcept C191015642 @default.
• W2125718087 hasConcept C202751555 @default.
• W2125718087 hasConcept C203014093 @default.
• W2125718087 hasConcept C2776090121 @default.
• W2125718087 hasConcept C2778063415 @default.
• W2125718087 hasConcept C2909406889 @default.
• W2125718087 hasConcept C3019040382 @default.
• W2125718087 hasConcept C31573885 @default.
• W2125718087 hasConcept C43759708 @default.
• W2125718087 hasConcept C55493867 @default.
• W2125718087 hasConcept C71924100 @default.
• W2125718087 hasConcept C79484868 @default.
• W2125718087 hasConcept C79879829 @default.
• W2125718087 hasConcept C86803240 @default.
• W2125718087 hasConcept C8891405 @default.
• W2125718087 hasConceptScore W2125718087C126322002 @default.
• W2125718087 hasConceptScore W2125718087C134018914 @default.
• W2125718087 hasConceptScore W2125718087C154317977 @default.
• W2125718087 hasConceptScore W2125718087C176324957 @default.
• W2125718087 hasConceptScore W2125718087C185592680 @default.
• W2125718087 hasConceptScore W2125718087C18903297 @default.
• W2125718087 hasConceptScore W2125718087C190283241 @default.
• W2125718087 hasConceptScore W2125718087C191015642 @default.
• W2125718087 hasConceptScore W2125718087C202751555 @default.
• W2125718087 hasConceptScore W2125718087C203014093 @default.
• W2125718087 hasConceptScore W2125718087C2776090121 @default.
• W2125718087 hasConceptScore W2125718087C2778063415 @default.
• W2125718087 hasConceptScore W2125718087C2909406889 @default.
• W2125718087 hasConceptScore W2125718087C3019040382 @default.
• W2125718087 hasConceptScore W2125718087C31573885 @default.

• next