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- W2125739288 abstract "Identifying novel mechanisms contributing to patient variability of drug response is a major goal of personalized medicine. Epigenetic regulation of gene expression by microRNA (miRNA) impacts a broad range of cellular processes, but knowledge of its regulation of drug-metabolizing enzymes (DMEs) is more limited. This review provides an introduction to miRNA and their functionality and summarizes known miRNA regulation of DME families, including the cytochrome P450s, UDP-glucuronoslytransferases, glutathione-S-transferases, sulfotransferases and aldo-keto reductases, and the transcription factors known to be involved in DME regulation." @default.
- W2125739288 created "2016-06-24" @default.
- W2125739288 creator A5044074760 @default.
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- W2125739288 date "2015-08-01" @default.
- W2125739288 modified "2023-09-23" @default.
- W2125739288 title "MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors." @default.
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- W2125739288 doi "https://doi.org/10.3109/03602532.2015.1076438" @default.
- W2125739288 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6309899" @default.
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