Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125767110> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2125767110 endingPage "163" @default.
- W2125767110 startingPage "147" @default.
- W2125767110 abstract "The bovine corneal opacity and permeability assay (BCOP) as originally described by Gautheron is now utilized by several laboratories to assess the eye irritation potential of individual chemicals, chemical blends, and consumer formulations. We have applied the principles established by Gautheron to the equipment and data available in our laboratory to devise a variation of this assay. This variation differs in three ways: how we evaluate corneal opacity, how we apply opacity and permeability measurements to predict irritation potential, and how we evaluate solid materials. For opacity measurement, a UV-VIS spectrophotometer is used to measure light absorbance. This contrasts with Gautheron's use of an opacitometer to measure changes in voltage as an indicator of opacity. Permeability is measured in the same manner but we interpret the results differently by applying them to a table of results relating to degrees of irritation potential. The corneal holding apparatus has also been modified to allow direct application of solids, such as laundry and dishwashing powders, onto the corneal surface. To evaluate these changes, we assayed the Cosmetic, Toiletry and Fragrance Association's (CTFA) phase III test materials, individual chemicals listed in the European Centre for Ectotoxicity and Toxicology of Chemicals’ (ECETOC) Eye Irritation Chemicals Reference Bank, surfactant raw materials, and Amway products with historical rabbit eye irritation data. High in vivo/in vitro correlations demonstrate the variations we have employed to be as predictive as earlier work and demonstrate the wide adaptability the BCOP provides to assess eye irritation potential." @default.
- W2125767110 created "2016-06-24" @default.
- W2125767110 creator A5024709886 @default.
- W2125767110 creator A5057120538 @default.
- W2125767110 creator A5063711270 @default.
- W2125767110 date "1996-01-01" @default.
- W2125767110 modified "2023-09-26" @default.
- W2125767110 title "A Novel Approach to Assessing Eye Irritation Potential Using the Bovine Corneal Opacity and Permeability Assay" @default.
- W2125767110 cites W1975293740 @default.
- W2125767110 cites W1984788884 @default.
- W2125767110 cites W2048744275 @default.
- W2125767110 cites W2053156664 @default.
- W2125767110 cites W2061241951 @default.
- W2125767110 cites W2086523668 @default.
- W2125767110 cites W2093808180 @default.
- W2125767110 cites W2095507569 @default.
- W2125767110 doi "https://doi.org/10.3109/15569529609048870" @default.
- W2125767110 hasPublicationYear "1996" @default.
- W2125767110 type Work @default.
- W2125767110 sameAs 2125767110 @default.
- W2125767110 citedByCount "29" @default.
- W2125767110 countsByYear W21257671102012 @default.
- W2125767110 countsByYear W21257671102013 @default.
- W2125767110 countsByYear W21257671102014 @default.
- W2125767110 countsByYear W21257671102015 @default.
- W2125767110 countsByYear W21257671102016 @default.
- W2125767110 countsByYear W21257671102017 @default.
- W2125767110 countsByYear W21257671102021 @default.
- W2125767110 crossrefType "journal-article" @default.
- W2125767110 hasAuthorship W2125767110A5024709886 @default.
- W2125767110 hasAuthorship W2125767110A5057120538 @default.
- W2125767110 hasAuthorship W2125767110A5063711270 @default.
- W2125767110 hasConcept C118487528 @default.
- W2125767110 hasConcept C120665830 @default.
- W2125767110 hasConcept C120882062 @default.
- W2125767110 hasConcept C121332964 @default.
- W2125767110 hasConcept C136229726 @default.
- W2125767110 hasConcept C185592680 @default.
- W2125767110 hasConcept C203014093 @default.
- W2125767110 hasConcept C2776882836 @default.
- W2125767110 hasConcept C2777063393 @default.
- W2125767110 hasConcept C2908834131 @default.
- W2125767110 hasConcept C2994251472 @default.
- W2125767110 hasConcept C41625074 @default.
- W2125767110 hasConcept C55493867 @default.
- W2125767110 hasConcept C60056205 @default.
- W2125767110 hasConcept C71924100 @default.
- W2125767110 hasConceptScore W2125767110C118487528 @default.
- W2125767110 hasConceptScore W2125767110C120665830 @default.
- W2125767110 hasConceptScore W2125767110C120882062 @default.
- W2125767110 hasConceptScore W2125767110C121332964 @default.
- W2125767110 hasConceptScore W2125767110C136229726 @default.
- W2125767110 hasConceptScore W2125767110C185592680 @default.
- W2125767110 hasConceptScore W2125767110C203014093 @default.
- W2125767110 hasConceptScore W2125767110C2776882836 @default.
- W2125767110 hasConceptScore W2125767110C2777063393 @default.
- W2125767110 hasConceptScore W2125767110C2908834131 @default.
- W2125767110 hasConceptScore W2125767110C2994251472 @default.
- W2125767110 hasConceptScore W2125767110C41625074 @default.
- W2125767110 hasConceptScore W2125767110C55493867 @default.
- W2125767110 hasConceptScore W2125767110C60056205 @default.
- W2125767110 hasConceptScore W2125767110C71924100 @default.
- W2125767110 hasIssue "2" @default.
- W2125767110 hasLocation W21257671101 @default.
- W2125767110 hasOpenAccess W2125767110 @default.
- W2125767110 hasPrimaryLocation W21257671101 @default.
- W2125767110 hasRelatedWork W2022775247 @default.
- W2125767110 hasRelatedWork W2026136095 @default.
- W2125767110 hasRelatedWork W2035603658 @default.
- W2125767110 hasRelatedWork W2059956784 @default.
- W2125767110 hasRelatedWork W2095247301 @default.
- W2125767110 hasRelatedWork W2125767110 @default.
- W2125767110 hasRelatedWork W2350137429 @default.
- W2125767110 hasRelatedWork W2751164993 @default.
- W2125767110 hasRelatedWork W3036933320 @default.
- W2125767110 hasRelatedWork W3186990989 @default.
- W2125767110 hasVolume "15" @default.
- W2125767110 isParatext "false" @default.
- W2125767110 isRetracted "false" @default.
- W2125767110 magId "2125767110" @default.
- W2125767110 workType "article" @default.