FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125770255> ?p ?o ?g. }

• W2125770255 abstract "Background Adalimumab (ADA) is commonly used in rheumatic diseases. Some patients do not respond or present a loss of response in the time. Till now, the decision in these cases was based only on the clinical evolution of the patient. For two years it is commercialized in Spain an enzyme linked immunosorbent assay (ELISA) for quantification of the free serum concentration of ADA, and of antibodies anti-adalimumab (Ac anti-ADA). Recently the manufacturer (Promonitor, Proteomika S.L., distributed by Menarini Diagnostics S.A.) has thrown a new version of this ELISA with significant changes for analytical workability of the test. Objectives To describe the results obtained of the comparative study between both versions of the ELISA commercialized for therapeutic drug monitoring of ADA. Methods We selected samples of patients with rheumatoid arthritis treated with ADA, with different concentrations of drug and Ac anti-drug that covered the whole analytical range of the assay. The samples were extracted just before the administration of ADA and remained frozen to -80oC up to his later analysis for duplicate with both available versions of the ELISA. Different lots from reagent were in use in every shift of analysis. The test was realized t of Student of samples paired to compare ADA’s average concentrations between both analyses realized with the same version of the test. By means of the statistician kappa the conformity was evaluated between the results obtained with the same version. There has been calculated the Coefficient of Correlation of Conformity (CCC) and his interval of confidence to know if the measurements with both versions (V1 or previous and V2 or updated) of the test show conformity. Results Statistically significant differences are not observed in the comparison of averages for ADA’s concentrations between both measurements of 24 samples by the V1 (7,62±6,15 y 7,13±4,08 mg/L, p=0,59), not between both measurements of 20 samples with the V2 (6,94±4,37 y 7,20±4,57 mg/L, p=0,08) of the ELISA. On having categorized the measurements for ranges (from 0 to 3, from 3 to 7, from 7 to 12 and major of 12 mg/L), is observed a conformity moderated between ADA’s concentrations obtained with V1 (Kappa 0,55; 0,18-0,79) and a very good conformity between ADA’s concentrations obtained with V2 (Kappa 0,91; 0,65-1,00), with a major discrepancy for the highest concentrations, whereas below 7 mg/L the degree of association is major, for having a number of cases classified under different practically void range in the different analized samples. In the ELISA for the detection of Ac anti-ADA there was obtained a conformity of 100%, 4 patients Ac anti-ADA met positives in both versions evaluated (n = 40). Conclusions The V2 of the test provides higher results of ADA’s concentration that the V1. Nevertheless, a major precision is observed in the range of near concentrations at the level of clinical decision. The new version of the ELISA allows the complete automation, which simplifies very much the analysis, and reduces significantly the variability in the repetitions of the samples. Disclosure of Interest None Declared" @default.
• W2125770255 created "2016-06-24" @default.
• W2125770255 creator A5018559972 @default.
• W2125770255 date "2013-06-01" @default.
• W2125770255 modified "2023-09-26" @default.
• W2125770255 title "THU0207 Comparative Study of Both Versions of an Immunoassay Commercialized for Therapeutic Drug Monitoring of Adalimumab" @default.
• W2125770255 doi "https://doi.org/10.1136/annrheumdis-2013-eular.735" @default.
• W2125770255 hasPublicationYear "2013" @default.
• W2125770255 type Work @default.
• W2125770255 sameAs 2125770255 @default.
• W2125770255 citedByCount "1" @default.
• W2125770255 countsByYear W21257702552019 @default.
• W2125770255 crossrefType "journal-article" @default.
• W2125770255 hasAuthorship W2125770255A5018559972 @default.
• W2125770255 hasConcept C126322002 @default.
• W2125770255 hasConcept C159654299 @default.
• W2125770255 hasConcept C203014093 @default.
• W2125770255 hasConcept C2777575956 @default.
• W2125770255 hasConcept C2780035454 @default.
• W2125770255 hasConcept C2780132546 @default.
• W2125770255 hasConcept C2780272996 @default.
• W2125770255 hasConcept C2780420688 @default.
• W2125770255 hasConcept C44249647 @default.
• W2125770255 hasConcept C71924100 @default.
• W2125770255 hasConcept C98274493 @default.
• W2125770255 hasConceptScore W2125770255C126322002 @default.
• W2125770255 hasConceptScore W2125770255C159654299 @default.
• W2125770255 hasConceptScore W2125770255C203014093 @default.
• W2125770255 hasConceptScore W2125770255C2777575956 @default.
• W2125770255 hasConceptScore W2125770255C2780035454 @default.
• W2125770255 hasConceptScore W2125770255C2780132546 @default.
• W2125770255 hasConceptScore W2125770255C2780272996 @default.
• W2125770255 hasConceptScore W2125770255C2780420688 @default.
• W2125770255 hasConceptScore W2125770255C44249647 @default.
• W2125770255 hasConceptScore W2125770255C71924100 @default.
• W2125770255 hasConceptScore W2125770255C98274493 @default.
• W2125770255 hasLocation W21257702551 @default.
• W2125770255 hasOpenAccess W2125770255 @default.
• W2125770255 hasPrimaryLocation W21257702551 @default.
• W2125770255 hasRelatedWork W1977295577 @default.
• W2125770255 hasRelatedWork W2124688782 @default.
• W2125770255 hasRelatedWork W2349526544 @default.
• W2125770255 hasRelatedWork W2350374200 @default.
• W2125770255 hasRelatedWork W2366381237 @default.
• W2125770255 hasRelatedWork W2371192825 @default.
• W2125770255 hasRelatedWork W2382107223 @default.
• W2125770255 hasRelatedWork W2382662882 @default.
• W2125770255 hasRelatedWork W2393808707 @default.
• W2125770255 hasRelatedWork W2419543431 @default.
• W2125770255 hasRelatedWork W2423867637 @default.
• W2125770255 hasRelatedWork W2725898427 @default.
• W2125770255 hasRelatedWork W2938106088 @default.
• W2125770255 hasRelatedWork W2979827275 @default.
• W2125770255 hasRelatedWork W3028643040 @default.
• W2125770255 hasRelatedWork W3030198704 @default.
• W2125770255 hasRelatedWork W3031132671 @default.
• W2125770255 hasRelatedWork W3033921997 @default.
• W2125770255 hasRelatedWork W3137039362 @default.
• W2125770255 hasRelatedWork W3139567626 @default.
• W2125770255 isParatext "false" @default.
• W2125770255 isRetracted "false" @default.
• W2125770255 magId "2125770255" @default.
• W2125770255 workType "article" @default.