FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125790564> ?p ?o ?g. }

• W2125790564 endingPage "8" @default.
• W2125790564 startingPage "1" @default.
• W2125790564 abstract "Foci of phosphorylated histone H2AX and ATM are the surrogate markers of DNA double strand breaks. We previously reported that the residual foci increased their size after irradiation, which amplifies DNA damage signals. Here, we addressed whether amplification of DNA damage signal is involved in replicative senescence of normal human diploid fibroblasts. Large phosphorylated H2AX foci (>1.5 μ m diameter) were specifically detected in presenescent cells. The frequency of cells with large foci was well correlated with that of cells positive for senescence-associated β -galactosidase staining. Hypoxic cell culture condition extended replicative life span of normal human fibroblast, and we found that the formation of large foci delayed in those cells. Our immuno-FISH analysis revealed that large foci partially localized at telomeres in senescent cells. Importantly, large foci of phosphorylated H2AX were always colocalized with phosphorylated ATM foci. Furthermore, Ser15-phosphorylated p53 showed colocalization with the large foci. Since the treatment of senescent cells with phosphoinositide 3-kinase inhibitor, wortmannin, suppressed p53 phosphorylation, it is suggested that amplification of DNA damage signaling sustains persistent activation of ATM-p53 pathway, which is essential for replicative senescence." @default.
• W2125790564 created "2016-06-24" @default.
• W2125790564 creator A5000189536 @default.
• W2125790564 creator A5049657246 @default.
• W2125790564 creator A5055846880 @default.
• W2125790564 creator A5077500802 @default.
• W2125790564 creator A5084874214 @default.
• W2125790564 date "2012-01-01" @default.
• W2125790564 modified "2023-10-15" @default.
• W2125790564 title "Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts" @default.
• W2125790564 cites W1760383320 @default.
• W2125790564 cites W1967636663 @default.
• W2125790564 cites W1970891016 @default.
• W2125790564 cites W1974936848 @default.
• W2125790564 cites W1977970646 @default.
• W2125790564 cites W1995819955 @default.
• W2125790564 cites W2000915272 @default.
• W2125790564 cites W2001209822 @default.
• W2125790564 cites W2004314923 @default.
• W2125790564 cites W2005029311 @default.
• W2125790564 cites W2008036432 @default.
• W2125790564 cites W2022079791 @default.
• W2125790564 cites W2027931017 @default.
• W2125790564 cites W2031187412 @default.
• W2125790564 cites W2041198010 @default.
• W2125790564 cites W2045409208 @default.
• W2125790564 cites W2050551830 @default.
• W2125790564 cites W2063918189 @default.
• W2125790564 cites W2102839588 @default.
• W2125790564 cites W2104908670 @default.
• W2125790564 cites W211395745 @default.
• W2125790564 cites W2131660936 @default.
• W2125790564 cites W2144626763 @default.
• W2125790564 cites W2146510832 @default.
• W2125790564 cites W2156930669 @default.
• W2125790564 cites W2172863736 @default.
• W2125790564 doi "https://doi.org/10.1155/2012/310534" @default.
• W2125790564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3461254" @default.
• W2125790564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23050037" @default.
• W2125790564 hasPublicationYear "2012" @default.
• W2125790564 type Work @default.
• W2125790564 sameAs 2125790564 @default.
• W2125790564 citedByCount "14" @default.
• W2125790564 countsByYear W21257905642012 @default.
• W2125790564 countsByYear W21257905642013 @default.
• W2125790564 countsByYear W21257905642014 @default.
• W2125790564 countsByYear W21257905642017 @default.
• W2125790564 countsByYear W21257905642018 @default.
• W2125790564 countsByYear W21257905642020 @default.
• W2125790564 countsByYear W21257905642021 @default.
• W2125790564 countsByYear W21257905642022 @default.
• W2125790564 crossrefType "journal-article" @default.
• W2125790564 hasAuthorship W2125790564A5000189536 @default.
• W2125790564 hasAuthorship W2125790564A5049657246 @default.
• W2125790564 hasAuthorship W2125790564A5055846880 @default.
• W2125790564 hasAuthorship W2125790564A5077500802 @default.
• W2125790564 hasAuthorship W2125790564A5084874214 @default.
• W2125790564 hasBestOaLocation W21257905641 @default.
• W2125790564 hasConcept C104317684 @default.
• W2125790564 hasConcept C11960822 @default.
• W2125790564 hasConcept C143191323 @default.
• W2125790564 hasConcept C143425029 @default.
• W2125790564 hasConcept C153911025 @default.
• W2125790564 hasConcept C177336024 @default.
• W2125790564 hasConcept C190474072 @default.
• W2125790564 hasConcept C2778308172 @default.
• W2125790564 hasConcept C2780381497 @default.
• W2125790564 hasConcept C40209533 @default.
• W2125790564 hasConcept C522857546 @default.
• W2125790564 hasConcept C54355233 @default.
• W2125790564 hasConcept C552990157 @default.
• W2125790564 hasConcept C64927066 @default.
• W2125790564 hasConcept C75217442 @default.
• W2125790564 hasConcept C81885089 @default.
• W2125790564 hasConcept C86803240 @default.
• W2125790564 hasConcept C95444343 @default.
• W2125790564 hasConceptScore W2125790564C104317684 @default.
• W2125790564 hasConceptScore W2125790564C11960822 @default.
• W2125790564 hasConceptScore W2125790564C143191323 @default.
• W2125790564 hasConceptScore W2125790564C143425029 @default.
• W2125790564 hasConceptScore W2125790564C153911025 @default.
• W2125790564 hasConceptScore W2125790564C177336024 @default.
• W2125790564 hasConceptScore W2125790564C190474072 @default.
• W2125790564 hasConceptScore W2125790564C2778308172 @default.
• W2125790564 hasConceptScore W2125790564C2780381497 @default.
• W2125790564 hasConceptScore W2125790564C40209533 @default.
• W2125790564 hasConceptScore W2125790564C522857546 @default.
• W2125790564 hasConceptScore W2125790564C54355233 @default.
• W2125790564 hasConceptScore W2125790564C552990157 @default.
• W2125790564 hasConceptScore W2125790564C64927066 @default.
• W2125790564 hasConceptScore W2125790564C75217442 @default.
• W2125790564 hasConceptScore W2125790564C81885089 @default.
• W2125790564 hasConceptScore W2125790564C86803240 @default.
• W2125790564 hasConceptScore W2125790564C95444343 @default.
• W2125790564 hasLocation W21257905641 @default.
• W2125790564 hasLocation W21257905642 @default.
• W2125790564 hasLocation W21257905643 @default.
• W2125790564 hasLocation W21257905644 @default.

• next