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- W2125799825 abstract "Abstract The molecular basis of species-specific differences in courtship behavior, a critical factor in preserving species boundaries, is poorly understood. Genetic analysis of all but the most closely related species is usually impossible, given the inviability of hybrids. We have therefore applied interspecific transformation of a single candidate behavioral locus, no-on-transient A (nonA), between Drosophila virilis and D. melanogaster, to investigate whether nonA, like the period gene, might encode species-specific behavioral information. Mutations in nonA can disrupt both visual behavior and the courtship song in D. melanogaster. The lovesong of nonAdiss mutant males superficially resembles that of D. virilis, a species that diverged from D. melanogaster 40–60 mya. Transformation of the cloned D. virilis nonA gene into D. melanogaster hosts carrying a synthetic deletion of the nonA locus restored normal visual function (the phenotype most sensitive to nonA mutation). However, the courtship song of transformant males showed several features characteristic of the corresponding D. virilis signal, indicating that nonA can act as a reservoir for species-specific information. This candidate gene approach, together with interspecific transformation, can therefore provide a direct avenue to explore potential speciation genes in genetically and molecularly tractable organisms such as Drosophila." @default.
- W2125799825 created "2016-06-24" @default.
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- W2125799825 date "2001-08-01" @default.
- W2125799825 modified "2023-10-18" @default.
- W2125799825 title "The <i>nonA</i> Gene in Drosophila Conveys Species-Specific Behavioral Characteristics" @default.
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- W2125799825 doi "https://doi.org/10.1093/genetics/158.4.1535" @default.
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