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• W2125808190 endingPage "7181" @default.
• W2125808190 startingPage "7160" @default.
• W2125808190 abstract "Alzheimer's disease (AD) is one of the most frequent causes of death and disability worldwide and has a significant clinical and socioeconomic impact. In the search for novel therapeutic strategies, serotonin 5-HT6 receptor (5-HT6R) has been proposed as a promising drug target for cognition enhancement in AD. This manuscript reviews the compelling evidence for the implication of this receptor in learning and memory processes. We have summarized the current status of the medicinal chemistry of 5-HT6R antagonists and the encouraging preclinical findings that demonstrate their significant procognitive behavioral effects in a number of learning paradigms, probably acting through modulation of multiple neurotransmitter systems and signaling pathways. The results of the ongoing clinical trials are eagerly awaited to shed some light on the validation of 5-HT6R antagonists as a new drug class for the treatment of symptomatic cognitive impairment in AD, either as stand-alone therapy or in combination with established agents." @default.
• W2125808190 created "2016-06-24" @default.
• W2125808190 creator A5046444163 @default.
• W2125808190 creator A5052627041 @default.
• W2125808190 creator A5057736472 @default.
• W2125808190 creator A5078484971 @default.
• W2125808190 creator A5090394808 @default.
• W2125808190 date "2014-06-03" @default.
• W2125808190 modified "2023-10-18" @default.
• W2125808190 title "Serotonin 5-HT₆ Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer’s Disease" @default.
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