FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125829771> ?p ?o ?g. }

• W2125829771 endingPage "625" @default.
• W2125829771 startingPage "617" @default.
• W2125829771 abstract "Phase II metabolism by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) is the predominant metabolic pathway during the first-pass metabolism of hesperetin (4′-methoxy-3′,5,7-trihydroxyflavanone). In the present study, we have determined the kinetics for glucuronidation and sulfonation of hesperetin by 12 individual UGT and 12 individual SULT enzymes as well as by human or rat small intestinal, colonic, and hepatic microsomal and cytosolic fractions. Results demonstrate that hesperetin is conjugated at positions 7 and 3′ and that major enzyme-specific differences in kinetics and regioselectivity for the UGT and SULT catalyzed conjugations exist. UGT1A9, UGT1A1, UGT1A7, UGT1A8, and UGT1A3 are the major enzymes catalyzing hesperetin glucuronidation, the latter only producing 7-<i>O</i>-glucuronide, whereas UGT1A7 produced mainly 3′-<i>O</i>-glucuronide. Furthermore, UGT1A6 and UGT2B4 only produce hesperetin 7-<i>O</i>-glucuronide, whereas UGT1A1, UGT1A8, UGT1A9, UGT1A10, UGT2B7, and UGT2B15 conjugate both positions. SULT1A2 and SULT1A1 catalyze preferably and most efficiently the formation of hesperetin 3′-<i>O</i>-sulfate, and SULT1C4 catalyzes preferably and most efficiently the formation of hesperetin 7-<i>O</i>-sulfate. Based on expression levels SULT1A3 and SULT1B1 also will probably play a role in the sulfo-conjugation of hesperetin in vivo. The results help to explain discrepancies in metabolite patterns determined in tissues or systems with different expression of UGTs and SULTs, e.g., hepatic and intestinal fractions or Caco-2 cells. The incubations with rat and human tissue samples support an important role for intestinal cells during first-pass metabolism in the formation of hesperetin 3′-<i>O</i>-glucuronide and 7-<i>O</i>-glucuronide, which appear to be the major hesperetin metabolites found in vivo." @default.
• W2125829771 created "2016-06-24" @default.
• W2125829771 creator A5007981202 @default.
• W2125829771 creator A5020427938 @default.
• W2125829771 creator A5029421999 @default.
• W2125829771 creator A5030763702 @default.
• W2125829771 creator A5047973336 @default.
• W2125829771 creator A5067727932 @default.
• W2125829771 creator A5069460407 @default.
• W2125829771 creator A5070735858 @default.
• W2125829771 creator A5075618257 @default.
• W2125829771 creator A5080235721 @default.
• W2125829771 creator A5086079715 @default.
• W2125829771 date "2010-01-07" @default.
• W2125829771 modified "2023-10-08" @default.
• W2125829771 title "Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples" @default.
• W2125829771 cites W1970221032 @default.
• W2125829771 cites W1972077998 @default.
• W2125829771 cites W1978408333 @default.
• W2125829771 cites W1986863961 @default.
• W2125829771 cites W1988718786 @default.
• W2125829771 cites W1990164787 @default.
• W2125829771 cites W1990581736 @default.
• W2125829771 cites W1991048885 @default.
• W2125829771 cites W1999339057 @default.
• W2125829771 cites W1999972814 @default.
• W2125829771 cites W2001914421 @default.
• W2125829771 cites W2003368011 @default.
• W2125829771 cites W2006054098 @default.
• W2125829771 cites W2015012628 @default.
• W2125829771 cites W2020113500 @default.
• W2125829771 cites W2022694430 @default.
• W2125829771 cites W2026833351 @default.
• W2125829771 cites W2031878765 @default.
• W2125829771 cites W2039201403 @default.
• W2125829771 cites W2040611122 @default.
• W2125829771 cites W2041945352 @default.
• W2125829771 cites W2061587734 @default.
• W2125829771 cites W2066833110 @default.
• W2125829771 cites W2069149565 @default.
• W2125829771 cites W2069459822 @default.
• W2125829771 cites W2077957170 @default.
• W2125829771 cites W2086695517 @default.
• W2125829771 cites W2102513234 @default.
• W2125829771 cites W2107255243 @default.
• W2125829771 cites W2114349412 @default.
• W2125829771 cites W2115153135 @default.
• W2125829771 cites W2123979498 @default.
• W2125829771 cites W2126394601 @default.
• W2125829771 cites W2141087444 @default.
• W2125829771 cites W2144374216 @default.
• W2125829771 cites W2155462152 @default.
• W2125829771 cites W2159190794 @default.
• W2125829771 cites W2165669901 @default.
• W2125829771 cites W2167233275 @default.
• W2125829771 doi "https://doi.org/10.1124/dmd.109.031047" @default.
• W2125829771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20056724" @default.
• W2125829771 hasPublicationYear "2010" @default.
• W2125829771 type Work @default.
• W2125829771 sameAs 2125829771 @default.
• W2125829771 citedByCount "77" @default.
• W2125829771 countsByYear W21258297712012 @default.
• W2125829771 countsByYear W21258297712013 @default.
• W2125829771 countsByYear W21258297712014 @default.
• W2125829771 countsByYear W21258297712015 @default.
• W2125829771 countsByYear W21258297712016 @default.
• W2125829771 countsByYear W21258297712017 @default.
• W2125829771 countsByYear W21258297712018 @default.
• W2125829771 countsByYear W21258297712019 @default.
• W2125829771 countsByYear W21258297712020 @default.
• W2125829771 countsByYear W21258297712021 @default.
• W2125829771 countsByYear W21258297712022 @default.
• W2125829771 countsByYear W21258297712023 @default.
• W2125829771 crossrefType "journal-article" @default.
• W2125829771 hasAuthorship W2125829771A5007981202 @default.
• W2125829771 hasAuthorship W2125829771A5020427938 @default.
• W2125829771 hasAuthorship W2125829771A5029421999 @default.
• W2125829771 hasAuthorship W2125829771A5030763702 @default.
• W2125829771 hasAuthorship W2125829771A5047973336 @default.
• W2125829771 hasAuthorship W2125829771A5067727932 @default.
• W2125829771 hasAuthorship W2125829771A5069460407 @default.
• W2125829771 hasAuthorship W2125829771A5070735858 @default.
• W2125829771 hasAuthorship W2125829771A5075618257 @default.
• W2125829771 hasAuthorship W2125829771A5080235721 @default.
• W2125829771 hasAuthorship W2125829771A5086079715 @default.
• W2125829771 hasConcept C181199279 @default.
• W2125829771 hasConcept C185592680 @default.
• W2125829771 hasConcept C2775904581 @default.
• W2125829771 hasConcept C2777252647 @default.
• W2125829771 hasConcept C2777469378 @default.
• W2125829771 hasConcept C2777477808 @default.
• W2125829771 hasConcept C2778004101 @default.
• W2125829771 hasConcept C2779054382 @default.
• W2125829771 hasConcept C2779186261 @default.
• W2125829771 hasConcept C2779907587 @default.
• W2125829771 hasConcept C55493867 @default.
• W2125829771 hasConcept C62231903 @default.
• W2125829771 hasConcept C87644729 @default.

• next