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- W2125844555 abstract "A library of functionalized chemical probes capable of reacting with ketosynthase-bound biosynthetic intermediates was prepared and utilized to explore in vivo polyketide diversification. Fermentation of ACP mutants of S. lasaliensis in the presence of the probes generated a range of unnatural polyketide derivatives, including novel putative lasalocid A derivatives characterized by variable aryl ketone moieties and linear polyketide chains (bearing alkyne/azide handles and fluorine) flanking the polyether scaffold. By providing direct information on microorganism tolerance and enzyme processing of unnatural malonyl-ACP analogues, as well as on the amenability of unnatural polyketides to further structural modifications, the chemical probes constitute invaluable tools for the development of novel mutasynthesis and synthetic biology." @default.
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- W2125844555 date "2014-09-11" @default.
- W2125844555 modified "2023-10-18" @default.
- W2125844555 title "Chemical Probes for the Functionalization of Polyketide Intermediates" @default.
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- W2125844555 doi "https://doi.org/10.1002/anie.201407448" @default.
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