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- W2125913996 abstract "Differences in safety profile between the four gadolinium chelates approved for clinical use by the Food and Drug Administration (FDA) are known, but have received in general little attention.[ 1 Runge V.M. Safety of approved MR contrast media for intravenous injection. J Magn Reson Imaging. 2000; 12: 205-213 Crossref PubMed Scopus (223) Google Scholar , 2 Tweedle M.F. Using radiotracers to characterize magnetic resonance imaging contrast agents. Invest Radiol. 2002; 37: 107-113 Crossref PubMed Scopus (7) Google Scholar ] The research subsequently described explores in greater depth subchronic toxicity evaluations for two of these agents (ProHance and Omniscan) in mice. Toxicity in female animals was studied, looking specifically at ovarian effects, an area not previously investigated. Given previously reported changes consistent with transmetallation (zinc for gadolinium with Omniscan), attention was also paid to markers of this effect, which include hair loss and urinary zinc.[ 3 Puttagunta N.R. Gibby W.A. Puttagunta V.L. Comparative transmetallation kinetics and thermodynamic stability of gadolinium-DTPA bis-glucosamide and other magnetic resonance imaging contrast media. Invest Radiol. 1996; 31: 619-624 Crossref PubMed Scopus (58) Google Scholar , 4 Puttagunta N.R. Gibby W.A. Smith G.T. Human in vivo comparative study of zinc and copper transmetallation after administration of magnetic resonance imaging contrast agents. Invest Radiol. 1996; 31: 739-742 Crossref PubMed Scopus (91) Google Scholar ]." @default.
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- W2125913996 date "2005-05-01" @default.
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- W2125913996 title "Subchronic Toxicity of the Gadolinium Chelates" @default.
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- W2125913996 doi "https://doi.org/10.1016/j.acra.2005.02.015" @default.
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