FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125928460> ?p ?o ?g. }

• W2125928460 endingPage "18" @default.
• W2125928460 startingPage "11" @default.
• W2125928460 abstract "One of the approaches to creating the regulators of G-protein-coupled receptors (GPCR) is the development of peptides that structurally correspond to the functionally important regions of the intracellular extracellular loops of the receptors. GPCR-peptides can selectively regulate the functional activity of homologous receptor and affect the hormonal signal transduction via the receptor. Among the peptides corresponding to the intracellular regions of GPCR, their derivatives modified with hydrophobic radicals exhibit the highest activity and selectivity of action in vitro and in vivo. Ample evidence demonstrates that lipophilic GPCR-peptides may be used to treat diseases and various abnormalities that depend on the functional activity of receptors homologous to them. In turn, the peptides corresponding to the extracellular regions of GPCR can be used as functional probes for studying the specific interaction between the receptors and their ligands, as well as for studying the etiology and pathogenesis of autoimmune diseases caused by the production of antibodies to GPCR antigenic determinants that are localized in the receptor extracellular loops. The present review focuses on the recent achievements in development and application of GPCR-peptides and on the prospects for their further use in medicine and fundamental biology." @default.
• W2125928460 created "2016-06-24" @default.
• W2125928460 creator A5023059510 @default.
• W2125928460 creator A5067687796 @default.
• W2125928460 date "2015-01-01" @default.
• W2125928460 modified "2023-10-16" @default.
• W2125928460 title "New achievements in development and application of GPCR-peptides" @default.
• W2125928460 cites W1544569292 @default.
• W2125928460 cites W1553329190 @default.
• W2125928460 cites W1581882526 @default.
• W2125928460 cites W1763096406 @default.
• W2125928460 cites W1968682237 @default.
• W2125928460 cites W1968713339 @default.
• W2125928460 cites W1973106521 @default.
• W2125928460 cites W1973458872 @default.
• W2125928460 cites W1983900052 @default.
• W2125928460 cites W1993842966 @default.
• W2125928460 cites W2000618586 @default.
• W2125928460 cites W2000827897 @default.
• W2125928460 cites W2005021955 @default.
• W2125928460 cites W2010739774 @default.
• W2125928460 cites W2010856023 @default.
• W2125928460 cites W2012822294 @default.
• W2125928460 cites W2022632237 @default.
• W2125928460 cites W2037130232 @default.
• W2125928460 cites W2042355069 @default.
• W2125928460 cites W2043395175 @default.
• W2125928460 cites W2053503928 @default.
• W2125928460 cites W2057833918 @default.
• W2125928460 cites W2062576061 @default.
• W2125928460 cites W2063504313 @default.
• W2125928460 cites W2064476297 @default.
• W2125928460 cites W2064634578 @default.
• W2125928460 cites W2066693617 @default.
• W2125928460 cites W2067856993 @default.
• W2125928460 cites W2070492751 @default.
• W2125928460 cites W2074654885 @default.
• W2125928460 cites W2094585278 @default.
• W2125928460 cites W2098161436 @default.
• W2125928460 cites W2098203510 @default.
• W2125928460 cites W2104912558 @default.
• W2125928460 cites W2112765727 @default.
• W2125928460 cites W2113492114 @default.
• W2125928460 cites W2119065663 @default.
• W2125928460 cites W2125884418 @default.
• W2125928460 cites W2127479320 @default.
• W2125928460 cites W2129476898 @default.
• W2125928460 cites W2134989582 @default.
• W2125928460 cites W2139198235 @default.
• W2125928460 cites W2146641981 @default.
• W2125928460 cites W2155056054 @default.
• W2125928460 cites W2159326971 @default.
• W2125928460 cites W2161939173 @default.
• W2125928460 cites W2166999542 @default.
• W2125928460 cites W2330016283 @default.
• W2125928460 cites W2410654228 @default.
• W2125928460 cites W2463111858 @default.
• W2125928460 doi "https://doi.org/10.1134/s0022093015010020" @default.
• W2125928460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25859600" @default.
• W2125928460 hasPublicationYear "2015" @default.
• W2125928460 type Work @default.
• W2125928460 sameAs 2125928460 @default.
• W2125928460 citedByCount "1" @default.
• W2125928460 countsByYear W21259284602017 @default.
• W2125928460 crossrefType "journal-article" @default.
• W2125928460 hasAuthorship W2125928460A5023059510 @default.
• W2125928460 hasAuthorship W2125928460A5067687796 @default.
• W2125928460 hasConcept C135285700 @default.
• W2125928460 hasConcept C170493617 @default.
• W2125928460 hasConcept C185592680 @default.
• W2125928460 hasConcept C26702167 @default.
• W2125928460 hasConcept C2778938600 @default.
• W2125928460 hasConcept C28406088 @default.
• W2125928460 hasConcept C42221972 @default.
• W2125928460 hasConcept C43587935 @default.
• W2125928460 hasConcept C55493867 @default.
• W2125928460 hasConcept C62478195 @default.
• W2125928460 hasConcept C79879829 @default.
• W2125928460 hasConcept C86803240 @default.
• W2125928460 hasConcept C95444343 @default.
• W2125928460 hasConceptScore W2125928460C135285700 @default.
• W2125928460 hasConceptScore W2125928460C170493617 @default.
• W2125928460 hasConceptScore W2125928460C185592680 @default.
• W2125928460 hasConceptScore W2125928460C26702167 @default.
• W2125928460 hasConceptScore W2125928460C2778938600 @default.
• W2125928460 hasConceptScore W2125928460C28406088 @default.
• W2125928460 hasConceptScore W2125928460C42221972 @default.
• W2125928460 hasConceptScore W2125928460C43587935 @default.
• W2125928460 hasConceptScore W2125928460C55493867 @default.
• W2125928460 hasConceptScore W2125928460C62478195 @default.
• W2125928460 hasConceptScore W2125928460C79879829 @default.
• W2125928460 hasConceptScore W2125928460C86803240 @default.
• W2125928460 hasConceptScore W2125928460C95444343 @default.
• W2125928460 hasIssue "1" @default.
• W2125928460 hasLocation W21259284601 @default.
• W2125928460 hasLocation W21259284602 @default.
• W2125928460 hasOpenAccess W2125928460 @default.
• W2125928460 hasPrimaryLocation W21259284601 @default.

• next