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• W2125937726 abstract "The conventional means of studying Epstein-Barr virus (EBV)-induced cytotoxic T-lymphocyte (CTL) memory, by in vitro stimulation with the latently infected autologous lymphoblastoid cell line (LCL), has important limitations. First, it gives no information on memory to lytic cycle antigens; second, it preferentially amplifies the dominant components of latent antigen-specific memory at the expense of key subdominant reactivities. Here we describe an alternative approach, based on in vitro stimulation with epitope peptide-loaded dendritic cells (DCs), which allows one to probe the CTL repertoire for any individual reactivity of choice; this method proved significantly more efficient than stimulation with peptide alone. Using this approach we first show that reactivities to the immunodominant and subdominant lytic cycle epitopes identified by T cells during primary EBV infection are regularly detectable in the CTL memory of virus carriers; this implies that in such carriers chronic virus replication remains under direct T-cell control. We further show that subdominant latent cycle reactivities to epitopes in the latent membrane protein LMP2, though rarely undetectable in LCL-stimulated populations, can be reactivated by DC stimulation and selectively expanded as polyclonal CTL lines; the adoptive transfer of such preparations may be of value in targeting certain EBV-positive malignancies." @default.
• W2125937726 created "2016-06-24" @default.
• W2125937726 creator A5005073157 @default.
• W2125937726 creator A5039856726 @default.
• W2125937726 date "1999-01-01" @default.
• W2125937726 modified "2023-10-14" @default.
• W2125937726 title "Accessing Epstein-Barr Virus-Specific T-Cell Memory with Peptide-Loaded Dendritic Cells" @default.
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• W2125937726 doi "https://doi.org/10.1128/jvi.73.1.334-342.1999" @default.
• W2125937726 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/103838" @default.
• W2125937726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9847337" @default.
• W2125937726 hasPublicationYear "1999" @default.
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