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• W2125946288 abstract "During the elongation cycle of protein biosynthesis, tRNAs traverse through the ribosome by consecutive binding to the 3 ribosomal binding sites (A-, P-, and E- sites). While the ribosomal A- and P-sites have been functionally well characterized in the past, the contribution of the E-site to protein biosynthesis is still poorly understood in molecular terms. Previous studies suggested an important functional interaction of the terminal residue A76 of E-tRNA with the nucleobase of the universally conserved 23S rRNA residue C2394. Using an atomic mutagenesis approach to introduce non-natural nucleoside analogs into the 23S rRNA, we could show that removal of the nucleobase or the ribose 2'-OH at C2394 had no effect on protein synthesis. On the other hand, our data disclose the importance of the highly conserved E-site base pair G2421-C2395 for effective translation. Ribosomes with a disrupted G2421-C2395 base pair are defective in tRNA binding to the E-site. This results in an impaired translation of genuine mRNAs, while homo-polymeric templates are not affected. Cumulatively our data emphasize the importance of E-site tRNA occupancy and in particular the intactness of the 23S rRNA base pair G2421-C2395 for productive protein biosynthesis." @default.
• W2125946288 created "2016-06-24" @default.
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• W2125946288 date "2015-01-02" @default.
• W2125946288 modified "2023-10-16" @default.
• W2125946288 title "The integrity of the G2421-C2395 base pair in the ribosomal E-site is crucial for protein synthesis" @default.
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• W2125946288 doi "https://doi.org/10.1080/15476286.2015.1017218" @default.
• W2125946288 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4615901" @default.
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