FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126000147> ?p ?o ?g. }

• W2126000147 endingPage "C114" @default.
• W2126000147 startingPage "C106" @default.
• W2126000147 abstract "We recently discovered that MG53, a muscle-specific tripartite motif (TRIM) family protein, functions as a sensor of oxidation to nucleate the assembly of cell membrane repair machinery. Our data showed that disulfide bond formation mediated by Cys242 is critical for MG53-mediated translocation of intracellular vesicles toward the injury sites. Here we test the hypothesis that leucine zipper motifs in the coiled-coil domain of MG53 constitute an additional mechanism that facilitates oligomerization of MG53 during cell membrane repair. Two leucine zipper motifs in the coiled-coil domain of MG53 (LZ1 - L176/L183/L190/V197 and LZ2 - L205/L212/L219/L226) are highly conserved across the different animal species. Chemical cross-linking studies show that LZ1 is critical for MG53 homodimerization, whereas LZ2 is not. Mutations of the conserved leucines into alanines in LZ1, not in LZ2, diminish the redox-dependent oligomerization of MG53. Live cell imaging studies demonstrate that the movement of green fluorescent protein (GFP)-tagged MG53 mutants (GFP-LA1 and GFP-LA2) is partially compromised in response to mechanical damage of the cell membrane, and the GFP-LA1/2 double mutant is completely ineffective in translocation toward the injury sites. In addition to the leucine zipper-mediated intermolecular interaction, redox-dependent cross talk between MG53 appears to be an obligatory step for cell membrane repair, since in vivo modification of cysteine residues with alkylating reagents can prevent the movement of MG53 toward the injury sites. Our data show that oxidation of the thiol group of Cys242 and leucine zipper-mediated interaction among the MG53 molecules both contribute to the nucleation process for MG53-mediated cell membrane repair." @default.
• W2126000147 created "2016-06-24" @default.
• W2126000147 creator A5001292860 @default.
• W2126000147 creator A5015264004 @default.
• W2126000147 creator A5024358171 @default.
• W2126000147 creator A5032758601 @default.
• W2126000147 creator A5088387320 @default.
• W2126000147 date "2011-07-01" @default.
• W2126000147 modified "2023-10-18" @default.
• W2126000147 title "Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair" @default.
• W2126000147 cites W1964166589 @default.
• W2126000147 cites W1979551416 @default.
• W2126000147 cites W1986335988 @default.
• W2126000147 cites W1988664606 @default.
• W2126000147 cites W1994513923 @default.
• W2126000147 cites W2000767238 @default.
• W2126000147 cites W2020746560 @default.
• W2126000147 cites W2027588950 @default.
• W2126000147 cites W2038698914 @default.
• W2126000147 cites W2047136624 @default.
• W2126000147 cites W2047693517 @default.
• W2126000147 cites W2055531511 @default.
• W2126000147 cites W2057380408 @default.
• W2126000147 cites W2062867597 @default.
• W2126000147 cites W2062899296 @default.
• W2126000147 cites W2071266197 @default.
• W2126000147 cites W2076115064 @default.
• W2126000147 cites W2077724627 @default.
• W2126000147 cites W2081832788 @default.
• W2126000147 cites W2090592602 @default.
• W2126000147 cites W2102679105 @default.
• W2126000147 cites W2103480378 @default.
• W2126000147 cites W2113333529 @default.
• W2126000147 cites W2116773729 @default.
• W2126000147 cites W2131037087 @default.
• W2126000147 cites W2134811841 @default.
• W2126000147 cites W2138446538 @default.
• W2126000147 cites W2147244688 @default.
• W2126000147 cites W2151766144 @default.
• W2126000147 cites W2161407389 @default.
• W2126000147 cites W2167344953 @default.
• W2126000147 doi "https://doi.org/10.1152/ajpcell.00382.2010" @default.
• W2126000147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3129825" @default.
• W2126000147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21525429" @default.
• W2126000147 hasPublicationYear "2011" @default.
• W2126000147 type Work @default.
• W2126000147 sameAs 2126000147 @default.
• W2126000147 citedByCount "61" @default.
• W2126000147 countsByYear W21260001472012 @default.
• W2126000147 countsByYear W21260001472013 @default.
• W2126000147 countsByYear W21260001472014 @default.
• W2126000147 countsByYear W21260001472015 @default.
• W2126000147 countsByYear W21260001472016 @default.
• W2126000147 countsByYear W21260001472017 @default.
• W2126000147 countsByYear W21260001472018 @default.
• W2126000147 countsByYear W21260001472019 @default.
• W2126000147 countsByYear W21260001472020 @default.
• W2126000147 countsByYear W21260001472021 @default.
• W2126000147 countsByYear W21260001472022 @default.
• W2126000147 countsByYear W21260001472023 @default.
• W2126000147 crossrefType "journal-article" @default.
• W2126000147 hasAuthorship W2126000147A5001292860 @default.
• W2126000147 hasAuthorship W2126000147A5015264004 @default.
• W2126000147 hasAuthorship W2126000147A5024358171 @default.
• W2126000147 hasAuthorship W2126000147A5032758601 @default.
• W2126000147 hasAuthorship W2126000147A5088387320 @default.
• W2126000147 hasBestOaLocation W21260001472 @default.
• W2126000147 hasConcept C104317684 @default.
• W2126000147 hasConcept C105782903 @default.
• W2126000147 hasConcept C11413529 @default.
• W2126000147 hasConcept C12554922 @default.
• W2126000147 hasConcept C142613039 @default.
• W2126000147 hasConcept C143065580 @default.
• W2126000147 hasConcept C1491633281 @default.
• W2126000147 hasConcept C156860981 @default.
• W2126000147 hasConcept C167625842 @default.
• W2126000147 hasConcept C181199279 @default.
• W2126000147 hasConcept C185592680 @default.
• W2126000147 hasConcept C2778106830 @default.
• W2126000147 hasConcept C2779201268 @default.
• W2126000147 hasConcept C41008148 @default.
• W2126000147 hasConcept C55493867 @default.
• W2126000147 hasConcept C55988834 @default.
• W2126000147 hasConcept C86803240 @default.
• W2126000147 hasConcept C95444343 @default.
• W2126000147 hasConceptScore W2126000147C104317684 @default.
• W2126000147 hasConceptScore W2126000147C105782903 @default.
• W2126000147 hasConceptScore W2126000147C11413529 @default.
• W2126000147 hasConceptScore W2126000147C12554922 @default.
• W2126000147 hasConceptScore W2126000147C142613039 @default.
• W2126000147 hasConceptScore W2126000147C143065580 @default.
• W2126000147 hasConceptScore W2126000147C1491633281 @default.
• W2126000147 hasConceptScore W2126000147C156860981 @default.
• W2126000147 hasConceptScore W2126000147C167625842 @default.
• W2126000147 hasConceptScore W2126000147C181199279 @default.
• W2126000147 hasConceptScore W2126000147C185592680 @default.
• W2126000147 hasConceptScore W2126000147C2778106830 @default.
• W2126000147 hasConceptScore W2126000147C2779201268 @default.

• next