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- W2126011282 abstract "The complex structure of mammalian central nervous system (CNS) originates from multipotent neural stem cells. Even in the adult brain neural stem cells persist and neurogenesis continues in some regions (Alvarez-Buylla and Garcia-Verdugo, 2002; Kempermann et al., 2004). Furthermore, recent observations are revealing a potential of non-neurogenic CNS regions to generate neurons in pathological conditions (Lie et al., 2004). Unraveling the mechanisms of neurogenesis is therefore important to understand the development, remodeling, and restoration of CNS structure and function. To facilitate experimental analysis of neurogenesis in the mammalian CNS, effective identification of stem or progenitor cells is crucial. Several groups have generated transgenic mice expressing a marker protein such as green fluorescent protein (GFP) under the control of nestin gene regulatory regions (Yamaguchi et al., 2000; Kawaguchi et al., 2001; Beech et al., 2004; Mignone et al., 2004). Nestin is a class IV intermediate filament expressed in stem cells and progenitor cells of the nervous system (Lendahl et al., 1990). This review aims to summarize how the transgenic mice have been utilized and discuss potentials and reservations of using this animal system. For the transgene construction, we utilized the second intron of nestin gene, which was known to drive the expression in neural stem and progenitor cells (Zimmerman et al., 1994). We also included the 5′ upstream region (promoter region) in the transgene construct, whose regulatory function is still unclear." @default.
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- W2126011282 date "2005-01-01" @default.
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- W2126011282 title "Analysis of neurogenesis using transgenic mice expressing GFP with nestin gene regulatory regions" @default.
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- W2126011282 doi "https://doi.org/10.1093/chemse/bjh142" @default.
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