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• W2126013663 abstract "The effects of combined administration of ethinylestradiol (E) and testosterone (T) were studied in castrated Sprague-Dawley rats. The hormones E and T were administered three times weekly on alternate days, subcutaneously in the inguinal region for 4 weeks, 30 days after castration. E- treated animals received injections of 3 �g/kg body weight (B.W), T- treated animals received 30 mg/kg B.W., combined testosterone and ethinylestradiol (T & E) - treated animals received injections of 30 mg/kg B.W. of T and 2 �g/kg B.W. of E. Control animals - were in two groups, castrated and intact both received injections of 5 ml/kg B.W. of normal saline. i) The T-treated prostate weight was significantly higher than in castrated control (P<0.05). (ii) The E- alone treated prostate weight was not significantly different from castrated control (P b0.05). iii) The combined T and E-treated prostate weight was significantly higher than in castrated control (P<0.05). Morphological findings: in the combined T and Etreated, the amount of connective tissue was well marked, there was an increase in the thickness of the epithelium and the size of the oval acini, relative to T-alone treated or the intact control. E-alone did not elicit any appreciable effect on the prostate, different from the castrated control. This finding demonstrates a synergistic effect of E on the prostate when administered along with T and also suggests that E may be involved in the pathophysiology of the abnormal enlargement of prostate gland." @default.
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• W2126013663 date "2007-08-30" @default.
• W2126013663 modified "2023-09-27" @default.
• W2126013663 title "Sex steroid induced changes on the morphology of prostate of sprague-dawley rats" @default.
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• W2126013663 doi "https://doi.org/10.5897/sre.9000838" @default.
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