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• W2126021594 abstract "The glomerular filtration barrier separates the blood from the urinary space and consists of two major cell types: podocytes and fenestrated endothelial cells. Mesangial cells sit between the capillary loops and provide structural support. Proliferation and loss of mesangial cells both are central findings in a number of renal diseases, including diabetic nephropathy and mesangiolysis, respectively. Using cell-specific gene targeting, it was shown previously that vascular endothelial growth factor A (VEGF-A) production by podocytes is required for glomerular endothelial cell migration, differentiation, and survival. For further investigation of the effect of gene dose and VEGF-A knockdown within the glomerulus, mice that carry one hypomorphic VEGF-A allele and one podocyte-specific null VEGF-A allele (<i>VEGF^hypo/loxP</i>,<i>Neph-Cre</i>^+/−) were generated; in these mice, the “allelic dose” of VEGF-A is intermediate between glomerular-specific heterozygous and null states. <i>VEGF^hypo/loxP</i>,<i>Neph-Cre</i>^+/− mice die at 3 wk of age from renal failure. Although endothelial cell defects are observed, striking loss of mesangial cells occurs postnatally. In addition, differentiated mesangial cells cannot be found in glomeruli of podocyte-specific null VEGF-A mice (<i>VEGF^loxP/loxP</i>,<i>Cre</i>^+/−). Together, these results demonstrate a key role for VEGF-A production in the podocyte for mesangial cell survival and differentiation." @default.
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• W2126021594 date "2006-03-01" @default.
• W2126021594 modified "2023-10-16" @default.
• W2126021594 title "Vascular Endothelial Growth Factor A Signaling in the Podocyte-Endothelial Compartment Is Required for Mesangial Cell Migration and Survival" @default.
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• W2126021594 doi "https://doi.org/10.1681/asn.2005080810" @default.
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