FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126030177> ?p ?o ?g. }

• W2126030177 endingPage "G409" @default.
• W2126030177 startingPage "G397" @default.
• W2126030177 abstract "Iron is an essential trace mineral that plays a number of important physiological roles in humans, including oxygen transport, energy metabolism, and neurotransmitter synthesis. Iron absorption by the proximal small bowel is a critical checkpoint in the maintenance of whole-body iron levels since, unlike most other essential nutrients, no regulated excretory systems exist for iron in humans. Maintaining proper iron levels is critical to avoid the adverse physiological consequences of either low or high tissue iron concentrations, as commonly occurs in iron-deficiency anemia and hereditary hemochromatosis, respectively. Exquisite regulatory mechanisms have thus evolved to modulate how much iron is acquired from the diet. Systemic sensing of iron levels is accomplished by a network of molecules that regulate transcription of the HAMP gene in hepatocytes, thus modulating levels of the serum-borne, iron-regulatory hormone hepcidin. Hepcidin decreases intestinal iron absorption by binding to the iron exporter ferroportin 1 on the basolateral surface of duodenal enterocytes, causing its internalization and degradation. Mucosal regulation of iron transport also occurs during low-iron states, via transcriptional (by hypoxia-inducible factor 2α) and posttranscriptional (by the iron-sensing iron-regulatory protein/iron-responsive element system) mechanisms. Recent studies demonstrated that these regulatory loops function in tandem to control expression or activity of key modulators of iron homeostasis. In health, body iron levels are maintained at appropriate levels; however, in several inherited disorders and in other pathophysiological states, iron sensing is perturbed and intestinal iron absorption is dysregulated. The iron-related phenotypes of these diseases exemplify the necessity of precisely regulating iron absorption to meet body demands." @default.
• W2126030177 created "2016-06-24" @default.
• W2126030177 creator A5012003620 @default.
• W2126030177 creator A5065319311 @default.
• W2126030177 creator A5077130877 @default.
• W2126030177 date "2014-08-15" @default.
• W2126030177 modified "2023-10-18" @default.
• W2126030177 title "Mechanistic and regulatory aspects of intestinal iron absorption" @default.
• W2126030177 cites W103117919 @default.
• W2126030177 cites W1484371793 @default.
• W2126030177 cites W1508143080 @default.
• W2126030177 cites W1520189306 @default.
• W2126030177 cites W1544810022 @default.
• W2126030177 cites W1568628619 @default.
• W2126030177 cites W1677338 @default.
• W2126030177 cites W1765432697 @default.
• W2126030177 cites W1785130811 @default.
• W2126030177 cites W1908089512 @default.
• W2126030177 cites W192250034 @default.
• W2126030177 cites W1964982621 @default.
• W2126030177 cites W1965527014 @default.
• W2126030177 cites W1966885686 @default.
• W2126030177 cites W1967222297 @default.
• W2126030177 cites W1967826144 @default.
• W2126030177 cites W1974266372 @default.
• W2126030177 cites W1974614940 @default.
• W2126030177 cites W1974844038 @default.
• W2126030177 cites W1975590431 @default.
• W2126030177 cites W1980042430 @default.
• W2126030177 cites W1986557716 @default.
• W2126030177 cites W1987724596 @default.
• W2126030177 cites W1991410899 @default.
• W2126030177 cites W1993106326 @default.
• W2126030177 cites W1994629986 @default.
• W2126030177 cites W1999149952 @default.
• W2126030177 cites W2000853310 @default.
• W2126030177 cites W2001394100 @default.
• W2126030177 cites W2002605005 @default.
• W2126030177 cites W2004015238 @default.
• W2126030177 cites W2005868568 @default.
• W2126030177 cites W2006765241 @default.
• W2126030177 cites W2007643926 @default.
• W2126030177 cites W2008110876 @default.
• W2126030177 cites W2008376250 @default.
• W2126030177 cites W2008711862 @default.
• W2126030177 cites W2015248217 @default.
• W2126030177 cites W2018782206 @default.
• W2126030177 cites W2020150065 @default.
• W2126030177 cites W2023382439 @default.
• W2126030177 cites W2023442218 @default.
• W2126030177 cites W2023865132 @default.
• W2126030177 cites W2025158365 @default.
• W2126030177 cites W2025930096 @default.
• W2126030177 cites W2026200 @default.
• W2126030177 cites W2026392783 @default.
• W2126030177 cites W2027035778 @default.
• W2126030177 cites W2029734855 @default.
• W2126030177 cites W2031180114 @default.
• W2126030177 cites W2034343221 @default.
• W2126030177 cites W2038444043 @default.
• W2126030177 cites W2040132197 @default.
• W2126030177 cites W2041715899 @default.
• W2126030177 cites W2041741136 @default.
• W2126030177 cites W2042212143 @default.
• W2126030177 cites W2043233398 @default.
• W2126030177 cites W2043254960 @default.
• W2126030177 cites W2049537480 @default.
• W2126030177 cites W2050280601 @default.
• W2126030177 cites W2051747959 @default.
• W2126030177 cites W2056282179 @default.
• W2126030177 cites W2059946602 @default.
• W2126030177 cites W2061342616 @default.
• W2126030177 cites W2063933584 @default.
• W2126030177 cites W2064702079 @default.
• W2126030177 cites W2068774954 @default.
• W2126030177 cites W2068877219 @default.
• W2126030177 cites W2069211473 @default.
• W2126030177 cites W2069517565 @default.
• W2126030177 cites W2070236309 @default.
• W2126030177 cites W2071546138 @default.
• W2126030177 cites W2072862521 @default.
• W2126030177 cites W2073271820 @default.
• W2126030177 cites W2082806735 @default.
• W2126030177 cites W2083962064 @default.
• W2126030177 cites W2084492146 @default.
• W2126030177 cites W2090165219 @default.
• W2126030177 cites W2094505735 @default.
• W2126030177 cites W2095329694 @default.
• W2126030177 cites W2101093867 @default.
• W2126030177 cites W2101339868 @default.
• W2126030177 cites W2103161920 @default.
• W2126030177 cites W2104657893 @default.
• W2126030177 cites W2105749655 @default.
• W2126030177 cites W2107079905 @default.
• W2126030177 cites W2108843246 @default.
• W2126030177 cites W2109966630 @default.
• W2126030177 cites W2111139384 @default.
• W2126030177 cites W2112677248 @default.

• next