FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126036700> ?p ?o ?g. }

• W2126036700 endingPage "3252" @default.
• W2126036700 startingPage "3246" @default.
• W2126036700 abstract "ABSTRACT Hydrophilic albumin microspheres are proposed as a new delivery system for amphotericin B (AMB; AMB microspheres). The acute toxicity of AMB microspheres was lower than that of the AMB-deoxycholate (AMB-Doc) reference formulation in hamsters. Lethal doses in healthy and infected animals were improved at least eight times. Intravenous bolus administration of doses of AMB microspheres up to 40 mg/kg of body weight did not produce acute symptoms of toxicity. The efficacy of this new formulation was tested against Leishmania infantum- infected hamsters at doses of 2, 10, 20, and 40 mg/kg. With the 2-mg/kg dose, the activity of AMB, as assessed through the parasite load reductions in the liver and spleen and the evolution of antibody levels, was also improved ( P < 0.05) by use of the AMB microsphere system. At the higher doses of 10, 20, and 40 mg/kg, reductions in parasite levels of more than 99% were achieved in the liver and spleen after the administration of AMB microspheres. A pharmacokinetic study was performed to study the serum, liver, and spleen AMB concentrations after administration of AMB microspheres and the reference formulation. Interestingly, a significant accumulation of AMB in the spleen and liver was observed after AMB microsphere administration. Our results suggest that this new formulation is a promising alternative to the conventional AMB-Doc formulation for the treatment of visceral leishmaniasis." @default.
• W2126036700 created "2016-06-24" @default.
• W2126036700 creator A5000934871 @default.
• W2126036700 creator A5004643083 @default.
• W2126036700 creator A5024799006 @default.
• W2126036700 creator A5031335472 @default.
• W2126036700 creator A5039709692 @default.
• W2126036700 creator A5046559710 @default.
• W2126036700 creator A5060818655 @default.
• W2126036700 creator A5070316599 @default.
• W2126036700 creator A5073902921 @default.
• W2126036700 date "2004-09-01" @default.
• W2126036700 modified "2023-10-17" @default.
• W2126036700 title "Treatment of Experimental Visceral Leishmaniasis with Amphotericin B in Stable Albumin Microspheres" @default.
• W2126036700 cites W11222034 @default.
• W2126036700 cites W1224204668 @default.
• W2126036700 cites W1489653454 @default.
• W2126036700 cites W1955120603 @default.
• W2126036700 cites W1975861244 @default.
• W2126036700 cites W1978263354 @default.
• W2126036700 cites W1992071749 @default.
• W2126036700 cites W1994879603 @default.
• W2126036700 cites W1994998334 @default.
• W2126036700 cites W2007319803 @default.
• W2126036700 cites W2012504003 @default.
• W2126036700 cites W2020136924 @default.
• W2126036700 cites W2021638730 @default.
• W2126036700 cites W2028387078 @default.
• W2126036700 cites W2031127010 @default.
• W2126036700 cites W2046306052 @default.
• W2126036700 cites W2053893508 @default.
• W2126036700 cites W2060548202 @default.
• W2126036700 cites W2100822928 @default.
• W2126036700 cites W2107017657 @default.
• W2126036700 cites W2108532733 @default.
• W2126036700 cites W2110054888 @default.
• W2126036700 cites W2114508410 @default.
• W2126036700 cites W2118415128 @default.
• W2126036700 cites W2119308265 @default.
• W2126036700 cites W2124876188 @default.
• W2126036700 cites W2126359778 @default.
• W2126036700 cites W2126954823 @default.
• W2126036700 cites W2127412756 @default.
• W2126036700 cites W2133634376 @default.
• W2126036700 cites W2142724371 @default.
• W2126036700 cites W2146638813 @default.
• W2126036700 cites W2148589496 @default.
• W2126036700 cites W2150593535 @default.
• W2126036700 cites W2162801555 @default.
• W2126036700 cites W2166032071 @default.
• W2126036700 cites W2168946125 @default.
• W2126036700 cites W2171848562 @default.
• W2126036700 cites W2174891711 @default.
• W2126036700 cites W2333757546 @default.
• W2126036700 cites W1759553517 @default.
• W2126036700 doi "https://doi.org/10.1128/aac.48.9.3246-3252.2004" @default.
• W2126036700 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/514726" @default.
• W2126036700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15328080" @default.
• W2126036700 hasPublicationYear "2004" @default.
• W2126036700 type Work @default.
• W2126036700 sameAs 2126036700 @default.
• W2126036700 citedByCount "59" @default.
• W2126036700 countsByYear W21260367002012 @default.
• W2126036700 countsByYear W21260367002013 @default.
• W2126036700 countsByYear W21260367002014 @default.
• W2126036700 countsByYear W21260367002015 @default.
• W2126036700 countsByYear W21260367002016 @default.
• W2126036700 countsByYear W21260367002017 @default.
• W2126036700 countsByYear W21260367002018 @default.
• W2126036700 countsByYear W21260367002019 @default.
• W2126036700 countsByYear W21260367002020 @default.
• W2126036700 countsByYear W21260367002021 @default.
• W2126036700 crossrefType "journal-article" @default.
• W2126036700 hasAuthorship W2126036700A5000934871 @default.
• W2126036700 hasAuthorship W2126036700A5004643083 @default.
• W2126036700 hasAuthorship W2126036700A5024799006 @default.
• W2126036700 hasAuthorship W2126036700A5031335472 @default.
• W2126036700 hasAuthorship W2126036700A5039709692 @default.
• W2126036700 hasAuthorship W2126036700A5046559710 @default.
• W2126036700 hasAuthorship W2126036700A5060818655 @default.
• W2126036700 hasAuthorship W2126036700A5070316599 @default.
• W2126036700 hasAuthorship W2126036700A5073902921 @default.
• W2126036700 hasBestOaLocation W21260367002 @default.
• W2126036700 hasConcept C112705442 @default.
• W2126036700 hasConcept C126322002 @default.
• W2126036700 hasConcept C127413603 @default.
• W2126036700 hasConcept C16005928 @default.
• W2126036700 hasConcept C165616093 @default.
• W2126036700 hasConcept C189942447 @default.
• W2126036700 hasConcept C203014093 @default.
• W2126036700 hasConcept C2776125364 @default.
• W2126036700 hasConcept C2776555147 @default.
• W2126036700 hasConcept C2777056448 @default.
• W2126036700 hasConcept C2778689377 @default.
• W2126036700 hasConcept C2779548794 @default.
• W2126036700 hasConcept C2779629538 @default.
• W2126036700 hasConcept C2780931953 @default.
• W2126036700 hasConcept C2781257258 @default.

• next