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- W2126042901 abstract "3D-microfluidic cell culture systems (3D-μFCCSs) support hepatocyte functions in vitro which can be further enhanced by controlled presentation of 100–200 pg/ml TGF-β1, thus mimicking the roles of supporting cells in co-cultures. Controlled presentation of TGF-β1 is achieved by either direct perfusion or in situ controlled release from gelatin microspheres immobilized in the 3D-μFCCS. Primary hepatocytes cultured for 7 days with the in situ controlled released TGF-β1 exhibited up to four-fold higher albumin secretion and two-fold higher phase I/II enzymatic activities, significantly improving the sensitivity of hepatocytes to acetaminophen-mediated hepatotoxicity, compared to hepatocytes cultured with directly perfused TGF-β1 or without TGF-β1. The controlled presentation of TGF-β1 enhanced hepatocyte functions in microfluidic systems without the complications of co-cultures, allowing for simplifications in drug testing and other hepatocyte-based applications." @default.
- W2126042901 created "2016-06-24" @default.
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- W2126042901 date "2009-08-01" @default.
- W2126042901 modified "2023-09-24" @default.
- W2126042901 title "The controlled presentation of TGF-β1 to hepatocytes in a 3D-microfluidic cell culture system" @default.
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- W2126042901 doi "https://doi.org/10.1016/j.biomaterials.2009.03.052" @default.
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