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- W2126106323 abstract "The lethal effect of 7 beta-hydroxycholesterol (7 beta-OHC) on neonatal rat astrocyte primary cultures and spontaneously transformed cell lines derived from them was investigated. Confluent astrocyte primary cultures were not affected by 30 microM 7 beta-OHC over a period of 72 h. In contrast, spontaneously transformed cells were killed by 20 microM 7 beta-OHC within the first 48 h. Further studies indicated that the cell lines metabolized 7 beta-OHC to a product the polarity of which was less than that of 7 beta-OHC. The metabolite was identified as 7 beta-OHC esterified on C-3 by naturally occurring fatty acids. Incubation of the cell lines with 0.5 microM metabolite markedly affected the cells within 24 h. These observations suggest that the 7 beta-OHC metabolite is implicated in the mechanism of action of 7 beta-OHC cytotoxicity on spontaneously transformed cells." @default.
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- W2126106323 date "1989-10-01" @default.
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- W2126106323 title "Effect of 7β-hydroxycholesterol on astrocyte primary cultures and derived spontaneously transformed cell lines: cytotoxicity and metabolism" @default.
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- W2126106323 doi "https://doi.org/10.1016/0167-4889(89)90140-7" @default.
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