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• W2126107189 abstract "Low serotonergic (5-HT) activity correlates with increased impulsive-aggressive behavior, while the opposite association may apply to cognitive impulsiveness. Both types of impulsivity are associated with attention-deficit/hyperactivity disorder (ADHD), and genes of functional significance for the 5-HT system are implicated in this disorder. Here we demonstrate the separation of aggressive and cognitive components of impulsivity from symptom ratings and test their association with 5-HT and functionally related genes using a family-based association test (FBAT-PC). Our sample consisted of 1180 offspring from 607 families from the International Multicenter ADHD Genetics (IMAGE) study. Impulsive symptoms were assessed using the long forms of the Conners and the Strengths and Difficulties parent and teacher questionnaires. Factor analysis showed that the symptoms aggregated into parent- and teacher-rated behavioral and cognitive impulsivity. We then selected 582 single nucleotide polymorphisms (SNPs) from 14 genes directly or indirectly related to 5-HT function. Associations between these SNPs and the behavioral/cognitive groupings of impulsive symptoms were evaluated using the FBAT-PC approach. In the FBAT-PC analysis for cognitive impulsivity 2 SNPs from the gene encoding phenylethanolamine N-methyltransferase (PNMT, the rate-limiting enzyme for adrenalin synthesis) attained corrected gene-wide significance. Nominal significance was shown for 12 SNPs from BDNF, DRD1, HTR1E, HTR2A, HTR3B, DAT1/SLC6A3, and TPH2 genes replicating reported associations with ADHD. For overt aggressive impulsivity nominal significance was shown for 6 SNPs from BDNF, DRD4, HTR1E, PNMT, and TPH2 genes that have also been reported to be associated with ADHD. Associations for cognitive impulsivity with a SERT/SLC6A4 variant (STin2: 12 repeats) and aggressive behavioral impulsivity with a DRD4 variant (exon 3: 3 repeats) are also described. A genetic influence on monoaminergic involvement in impulsivity shown by children with ADHD was found. There were trends for separate and overlapping influences on impulsive-aggressive behavior and cognitive impulsivity, where an association with PNMT (and arousal mechanisms affected by its activity) was more clearly involved in the latter. Serotonergic and dopaminergic mechanisms were implicated in both forms of impulsivity with a wider range of serotonergic mechanisms (each with a small effect) potentially influencing cognitive impulsivity. These preliminary results should be followed up with an examination of environmental influences and associations with performance on tests of impulsivity in the laboratory." @default.
• W2126107189 created "2016-06-24" @default.
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• W2126107189 date "2008-01-01" @default.
• W2126107189 modified "2023-10-07" @default.
• W2126107189 title "The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis" @default.
• W2126107189 cites W108416319 @default.
• W2126107189 cites W1509504473 @default.
• W2126107189 cites W1517585079 @default.
• W2126107189 cites W1713262499 @default.
• W2126107189 cites W1850225444 @default.
• W2126107189 cites W1935659880 @default.
• W2126107189 cites W194374781 @default.
• W2126107189 cites W1964893104 @default.
• W2126107189 cites W1966626190 @default.
• W2126107189 cites W1969029136 @default.
• W2126107189 cites W1969858197 @default.
• W2126107189 cites W1970773591 @default.
• W2126107189 cites W1972879501 @default.
• W2126107189 cites W1975234976 @default.
• W2126107189 cites W1975701706 @default.
• W2126107189 cites W1978387829 @default.
• W2126107189 cites W1978443369 @default.
• W2126107189 cites W1978580001 @default.
• W2126107189 cites W1981132558 @default.
• W2126107189 cites W1984836432 @default.
• W2126107189 cites W1985658156 @default.
• W2126107189 cites W1992488100 @default.
• W2126107189 cites W1999147677 @default.
• W2126107189 cites W2000258781 @default.
• W2126107189 cites W2003619331 @default.
• W2126107189 cites W2007093632 @default.
• W2126107189 cites W2009117601 @default.
• W2126107189 cites W2010604180 @default.
• W2126107189 cites W2012696549 @default.
• W2126107189 cites W2014467790 @default.
• W2126107189 cites W2020697093 @default.
• W2126107189 cites W2021592118 @default.
• W2126107189 cites W2023230298 @default.
• W2126107189 cites W2025802167 @default.
• W2126107189 cites W2028480590 @default.
• W2126107189 cites W2028851302 @default.
• W2126107189 cites W2034251427 @default.
• W2126107189 cites W2037097912 @default.
• W2126107189 cites W2043634812 @default.
• W2126107189 cites W2044093682 @default.
• W2126107189 cites W2045446575 @default.
• W2126107189 cites W2046958766 @default.
• W2126107189 cites W2047264337 @default.
• W2126107189 cites W2052024304 @default.
• W2126107189 cites W2054108479 @default.
• W2126107189 cites W2057400117 @default.
• W2126107189 cites W2057944946 @default.
• W2126107189 cites W2061673814 @default.
• W2126107189 cites W2063196063 @default.
• W2126107189 cites W2064260924 @default.
• W2126107189 cites W2064748184 @default.
• W2126107189 cites W2065914771 @default.
• W2126107189 cites W2073508055 @default.
• W2126107189 cites W2074175544 @default.
• W2126107189 cites W2075659401 @default.
• W2126107189 cites W2101071431 @default.
• W2126107189 cites W2104292214 @default.
• W2126107189 cites W2108747760 @default.
• W2126107189 cites W2111011244 @default.
• W2126107189 cites W2112235751 @default.
• W2126107189 cites W2114547253 @default.
• W2126107189 cites W2115518880 @default.
• W2126107189 cites W2119472450 @default.
• W2126107189 cites W2125080419 @default.
• W2126107189 cites W2125396305 @default.
• W2126107189 cites W2128351132 @default.
• W2126107189 cites W2130195204 @default.
• W2126107189 cites W2133967962 @default.
• W2126107189 cites W2137257511 @default.
• W2126107189 cites W2144194194 @default.
• W2126107189 cites W2149693794 @default.
• W2126107189 cites W2150934124 @default.
• W2126107189 cites W2156645869 @default.

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