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• W2126108715 abstract "Thymectomy of neonatal mice can result in the development of autoimmune pathology. It has been proposed that thymic output of regulatory T (T reg) cells is delayed during ontogeny and that the development of autoimmune disease in neonatally thymectomized mice is caused by the escape of self-reactive T cells before thymectomy without accompanying T reg cells. However, the kinetics of T reg cell production within the thymus during ontogeny has not been assessed. We demonstrate that the development of Foxp3-expressing T reg cells is substantially delayed relative to nonregulatory thymocytes during ontogeny. Based on our data, we speculate that induction of Foxp3 in developing thymocytes and, thus, commitment to the T reg cell lineage is facilitated by a signal largely associated with the thymic medulla." @default.
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• W2126108715 date "2005-10-03" @default.
• W2126108715 modified "2023-09-30" @default.
• W2126108715 title "Developmental regulation of Foxp3 expression during ontogeny" @default.
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• W2126108715 doi "https://doi.org/10.1084/jem.20050784" @default.
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