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- W2126116198 abstract "80 specimens of mammary tissue presenting benign and malignant changes were subjected to biopsy with a view to disclosing activity of unspecific a'lkaline phosphatases. The material comprised 40 carcinomas, 32 cases of fibroadenomatosis, 7 fibroadenomas, and 1 carcinoma in situ. In the cases of carcinoma no or only slight phosphatase activity was found in the tumour cells. The surrounding stroma often showed “reaction zones” formed by proliferating fibroblasts with high phosphatase activity. This stromal response was found in 65 per cent of the biopsy specimens of carcinoma, while another 7.5 per cent were doubtfully positive. The incidence of reaction zones was seen to increase appreciably with rising grades of tumour anaplasia. (Grade I 33.3 per cent, grade II 65 per cent, and grade III 90.9 per cent). Further, correlation was found between reaction zones and stromal lymphocyte infiltrates. The pathogenesis of the reaction zones is discussed, and the conclusion has been drawn that a stromal reaction against the tumour must be the most likely hypothesis. In fibroadenomatosis 18.8 per cent of the biopsies revealed reaction zones. The question has been considered whether the observation might be employed for a delimitation of a high risk group of patients with fibroadenomatosis." @default.
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- W2126116198 date "2009-08-15" @default.
- W2126116198 modified "2023-10-16" @default.
- W2126116198 title "STROMAL RESPONSE IN BREAST CARCINOMA AND FIBROADENOMATOSIS, ESTIMATED BY THE AID OF THE ALKALINE PHOSPHATASE ACTIVITY" @default.
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- W2126116198 doi "https://doi.org/10.1111/j.1699-0463.1971.tb01827.x" @default.
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