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• W2126127777 abstract "The expression level of microRNA (miR)‑92a has been proven to increase during the development of colorectal adenocarcinoma (CA) and has been verified at the cellular, plasma and fecal levels by various quantitative methods. However, a method to quantitate the expression level using tissue sections has not been established. To do this, in situ hybridization (ISH) and multispectral imaging microscopy (MSI) were introduced to quantitate miR‑92a expression on the microscopic level. ISH of miR‑92a was first performed on 34 tissue samples of CA and adenomas with high‑grade and low‑grade intraepithelial neoplasms, while 31 paralesional normal tissue samples were defined as the control. Subsequently, a MSI technique was applied to quantitate the hybridization signal in terms of optical density (OD) at the visible wavelength. A t‑test with unequal variance was used to examine the statistical significance between the groups. Despite all 34 tissue sections demonstrating at least partial positivity of miR‑92a expression following ISH, visual grading was inconclusive. As such, the signal of ISH was transformed in terms of OD and further analyzed by employing the MSI system. A statistically significant difference was observed between the expression levels of miR‑92a in CA and the paralesional normal controls. By contrast, a poor correlation was revealed between visual and spectral grading. The co‑utilization of ISH and MSI generated a legible observation in the expression level of miR‑92a, revealing the dynamic change in miR‑92a expression in the progression of the disease and providing important information for further functional investigation." @default.
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• W2126127777 date "2014-12-18" @default.
• W2126127777 modified "2023-10-16" @default.
• W2126127777 title "Quantitation of microRNA-92a in colorectal adenocarcinoma and its precancerous lesions: Co-utilization of in situ hybridization and spectral imaging" @default.
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• W2126127777 doi "https://doi.org/10.3892/ol.2014.2813" @default.
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