FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126147657> ?p ?o ?g. }

• W2126147657 endingPage "1348" @default.
• W2126147657 startingPage "1340" @default.
• W2126147657 abstract "In the present study, we examined the roles of natural killer T (NKT) cells in host defence against Legionella pneumophila in a mouse model. The survival rate of NKT cell-deficient J α 281 knock-out (KO) mice was significantly higher than that of wild-type mice. There was no bacterial overgrowth in the lungs, but J α 281 KO mice showed enhanced pulmonary clearance at a later stage of infection, compared with their wild-type counterparts. The severity of lung injury in L. pneumophila -infected J α 281 KO mice was less, as indicated by lung permeability measurements, such as lung weight and bronchoalveolar lavage fluid albumin concentration. Recruitment of inflammatory cells in the lungs was approximately twofold greater in J α 281 KO mice on day 3. Interestingly, higher values of interleukin (IL)-1 β and IL-18, and increased caspase-1 activity were noted in the lungs of J α 281 KO mice from an early time point (6 h). Exogenous α -galactosylceramide, a ligand of NKT cells, induced IL-12 and gamma interferon at 6 h, but suppressed IL-1 β at later time points in wild-type, whereas no effects were evident in J α 281 KO mice, as expected. Systemic administration of heat-killed L. pneumophila , but not Escherichia coli LPS, reproduced exaggerated production of IL-1 β in the lungs of J α 281 KO mice. These results demonstrate that NKT cells play a role in host defence against L. pneumophila , which is characterized by enhanced lung injury and decreased accumulation of inflammatory cells in the lungs. The regulation of IL-1 β , IL-18 and caspase-1 may be associated with the modulating effect of host responses by NKT cells." @default.
• W2126147657 created "2016-06-24" @default.
• W2126147657 creator A5002303307 @default.
• W2126147657 creator A5015238774 @default.
• W2126147657 creator A5035894578 @default.
• W2126147657 creator A5040832259 @default.
• W2126147657 creator A5042227330 @default.
• W2126147657 creator A5056798404 @default.
• W2126147657 creator A5057133409 @default.
• W2126147657 creator A5073537109 @default.
• W2126147657 creator A5080526180 @default.
• W2126147657 creator A5081522457 @default.
• W2126147657 creator A5091790780 @default.
• W2126147657 date "2008-11-01" @default.
• W2126147657 modified "2023-10-16" @default.
• W2126147657 title "Paradoxically high resistance of natural killer T (NKT) cell-deficient mice to Legionella pneumophila: another aspect of NKT cells for modulation of host responses" @default.
• W2126147657 cites W1575883964 @default.
• W2126147657 cites W1632817771 @default.
• W2126147657 cites W1663753629 @default.
• W2126147657 cites W1799419298 @default.
• W2126147657 cites W1958291016 @default.
• W2126147657 cites W1963617896 @default.
• W2126147657 cites W1965015119 @default.
• W2126147657 cites W1972093499 @default.
• W2126147657 cites W1976102880 @default.
• W2126147657 cites W1983066167 @default.
• W2126147657 cites W1986997900 @default.
• W2126147657 cites W1987463569 @default.
• W2126147657 cites W1988819087 @default.
• W2126147657 cites W1995529916 @default.
• W2126147657 cites W2016503643 @default.
• W2126147657 cites W2023249242 @default.
• W2126147657 cites W2030024653 @default.
• W2126147657 cites W2030616236 @default.
• W2126147657 cites W2036504193 @default.
• W2126147657 cites W2038034087 @default.
• W2126147657 cites W2040919444 @default.
• W2126147657 cites W2042513494 @default.
• W2126147657 cites W2045464759 @default.
• W2126147657 cites W2069102137 @default.
• W2126147657 cites W2069502810 @default.
• W2126147657 cites W2082058005 @default.
• W2126147657 cites W2090940365 @default.
• W2126147657 cites W2090979926 @default.
• W2126147657 cites W2106280019 @default.
• W2126147657 cites W2106958120 @default.
• W2126147657 cites W2109879905 @default.
• W2126147657 cites W2119256241 @default.
• W2126147657 cites W2122498796 @default.
• W2126147657 cites W2124749429 @default.
• W2126147657 cites W2126829399 @default.
• W2126147657 cites W2127364256 @default.
• W2126147657 cites W2130156413 @default.
• W2126147657 cites W2132812816 @default.
• W2126147657 cites W2135405629 @default.
• W2126147657 cites W2139685284 @default.
• W2126147657 cites W2144467901 @default.
• W2126147657 cites W2149580256 @default.
• W2126147657 cites W2160137443 @default.
• W2126147657 cites W2161320421 @default.
• W2126147657 cites W2167309621 @default.
• W2126147657 cites W2169289106 @default.
• W2126147657 cites W2170266529 @default.
• W2126147657 cites W2170819998 @default.
• W2126147657 cites W2231727345 @default.
• W2126147657 cites W3143755808 @default.
• W2126147657 cites W4254839291 @default.
• W2126147657 cites W4313305956 @default.
• W2126147657 doi "https://doi.org/10.1099/jmm.0.47747-0" @default.
• W2126147657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18927410" @default.
• W2126147657 hasPublicationYear "2008" @default.
• W2126147657 type Work @default.
• W2126147657 sameAs 2126147657 @default.
• W2126147657 citedByCount "7" @default.
• W2126147657 countsByYear W21261476572013 @default.
• W2126147657 countsByYear W21261476572014 @default.
• W2126147657 countsByYear W21261476572015 @default.
• W2126147657 countsByYear W21261476572016 @default.
• W2126147657 countsByYear W21261476572017 @default.
• W2126147657 crossrefType "journal-article" @default.
• W2126147657 hasAuthorship W2126147657A5002303307 @default.
• W2126147657 hasAuthorship W2126147657A5015238774 @default.
• W2126147657 hasAuthorship W2126147657A5035894578 @default.
• W2126147657 hasAuthorship W2126147657A5040832259 @default.
• W2126147657 hasAuthorship W2126147657A5042227330 @default.
• W2126147657 hasAuthorship W2126147657A5056798404 @default.
• W2126147657 hasAuthorship W2126147657A5057133409 @default.
• W2126147657 hasAuthorship W2126147657A5073537109 @default.
• W2126147657 hasAuthorship W2126147657A5080526180 @default.
• W2126147657 hasAuthorship W2126147657A5081522457 @default.
• W2126147657 hasAuthorship W2126147657A5091790780 @default.
• W2126147657 hasBestOaLocation W21261476571 @default.
• W2126147657 hasConcept C126322002 @default.
• W2126147657 hasConcept C139563560 @default.
• W2126147657 hasConcept C203014093 @default.
• W2126147657 hasConcept C2776090121 @default.
• W2126147657 hasConcept C2776118409 @default.
• W2126147657 hasConcept C2777714996 @default.

• next