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• W2126150900 abstract "Background/Aims: The hepatotropic conjugate of adenine arabinoside monophosphate with lactosaminated poly-l-lysine (l-Poly(Lys)) must have a high solubility in order to be injected in a small volume compatible with the intramuscular route. In this paper the molecular weights of Poly(Lys) which allowed the synthesis of conjugates with the properties of high solubility and limited loss by the kidney were determined and a procedure for obtaining Poly(Lys) preparations with the required range of polymerization has been described. Methods: Conjugates were prepared using Poly(Lys) of different molecular weights obtained by the procedure described here or purchased from a commercial source. Their solubility and renal loss in mice was determined. Results: Poly(Lys) with molecular weights ranging from 45000 and 65000 Da guarantees high solubility and low renal elimination of the conjugates. Conjugate preparations with these properties, intramuscularly administered to woodchuch hepatitis virus-infected woodchucks for 37 days at a daily dose of 5.8 mg/kg exerted a strong antiviral activity. These preparations were devoid of acute toxicity in rat and caused no toxic effects when injected intramuscularly daily for 28 days at a dose ten times higher than that active in woodchucks. Conclusions: The results support the possibility of a clinical use of l-Poly(Lys) to obtain liver targeting of adenine arabinoside monophosphate for the treatment of chronic hepatitis B virus infection." @default.
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• W2126150900 date "1997-02-01" @default.
• W2126150900 modified "2023-10-03" @default.
• W2126150900 title "Hepatotropic conjugate of adenine arabinoside monophosphate with lactosaminated poly-l-lysine" @default.
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• W2126150900 doi "https://doi.org/10.1016/s0168-8278(97)80038-4" @default.
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