FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126161397> ?p ?o ?g. }

• W2126161397 endingPage "547" @default.
• W2126161397 startingPage "539" @default.
• W2126161397 abstract "Purpose: Radiation-induced heart disease (RIHD) is a serious side-effect of thoracic radiotherapy. The epidermal growth factor receptor (EGFR) pathway is essential for the function and survival of cardiomyocytes. Hence, agents that target the EGFR pathway are cardiotoxic. Tocotrienols protect from radiation injury, but may also enhance the therapeutic effects of EGFR pathway inhibitors in cancer treatment. This study investigated the effects of local irradiation on the EGFR pathway in the heart and tests whether tocotrienols may modify radiation-induced changes in this pathway.Methods: Male Sprague-Dawley rats received image-guided localized heart irradiation with 21 Gy. Twenty four hours before irradiation, rats received a single dose of tocotrienol-enriched formulation or vehicle by oral gavage. At time points from 2 h to 9 months after irradiation, left ventricular expression of EGFR pathway mediators was studied.Results: Irradiation caused a decrease in the expression of epidermal growth factor (EGF) and neuregulin-1 (Nrg-1) mRNA from 6 h up to 10 weeks, followed by an upregulation of these ligands and the receptor erythroblastic leukemia viral oncogene homolog (ErbB)4 at 6 months. In addition, the upregulation of Nrg-1 was statistically significant up to 9 months after irradiation. A long-term upregulation of ErbB2 protein did not coincide with changes in transcription or post-translational interaction with the chaperone heat shock protein 90 (HSP90). Pretreatment with tocotrienols prevented radiation-induced changes at 2 weeks.Conclusions: Local heart irradiation causes long-term changes in the EGFR pathway. Studies have to address how radiation may interact with cardiotoxic effects of EGFR inhibitors." @default.
• W2126161397 created "2016-06-24" @default.
• W2126161397 creator A5014015669 @default.
• W2126161397 creator A5022191226 @default.
• W2126161397 creator A5055459942 @default.
• W2126161397 creator A5055510159 @default.
• W2126161397 creator A5065959120 @default.
• W2126161397 creator A5076803774 @default.
• W2126161397 creator A5081161443 @default.
• W2126161397 creator A5085392481 @default.
• W2126161397 creator A5088241361 @default.
• W2126161397 date "2013-04-16" @default.
• W2126161397 modified "2023-10-18" @default.
• W2126161397 title "Effects of radiation on the epidermal growth factor receptor pathway in the heart" @default.
• W2126161397 cites W1601571585 @default.
• W2126161397 cites W1915418979 @default.
• W2126161397 cites W1964224666 @default.
• W2126161397 cites W1964580006 @default.
• W2126161397 cites W1964867222 @default.
• W2126161397 cites W1970893866 @default.
• W2126161397 cites W1978030865 @default.
• W2126161397 cites W1980141913 @default.
• W2126161397 cites W1982210988 @default.
• W2126161397 cites W1982440275 @default.
• W2126161397 cites W1983530651 @default.
• W2126161397 cites W1984502501 @default.
• W2126161397 cites W1987915211 @default.
• W2126161397 cites W1990180383 @default.
• W2126161397 cites W1995266526 @default.
• W2126161397 cites W1996530624 @default.
• W2126161397 cites W1996721080 @default.
• W2126161397 cites W2001442729 @default.
• W2126161397 cites W2001968947 @default.
• W2126161397 cites W2011242979 @default.
• W2126161397 cites W2014571862 @default.
• W2126161397 cites W2016010426 @default.
• W2126161397 cites W2017600869 @default.
• W2126161397 cites W2017729853 @default.
• W2126161397 cites W2023058728 @default.
• W2126161397 cites W2024651005 @default.
• W2126161397 cites W2026482598 @default.
• W2126161397 cites W2029320277 @default.
• W2126161397 cites W2031944234 @default.
• W2126161397 cites W2045632869 @default.
• W2126161397 cites W2050674912 @default.
• W2126161397 cites W2050718666 @default.
• W2126161397 cites W2054911540 @default.
• W2126161397 cites W2058629308 @default.
• W2126161397 cites W2060329407 @default.
• W2126161397 cites W2062197280 @default.
• W2126161397 cites W2068560722 @default.
• W2126161397 cites W2077517947 @default.
• W2126161397 cites W2080330276 @default.
• W2126161397 cites W2086147267 @default.
• W2126161397 cites W2088466438 @default.
• W2126161397 cites W2089478474 @default.
• W2126161397 cites W2092897704 @default.
• W2126161397 cites W2094864993 @default.
• W2126161397 cites W2095059099 @default.
• W2126161397 cites W2096098020 @default.
• W2126161397 cites W2104644601 @default.
• W2126161397 cites W2116036462 @default.
• W2126161397 cites W2132785031 @default.
• W2126161397 cites W2140074016 @default.
• W2126161397 cites W2141393790 @default.
• W2126161397 cites W2142826108 @default.
• W2126161397 cites W2145726986 @default.
• W2126161397 cites W2151664404 @default.
• W2126161397 cites W2152647863 @default.
• W2126161397 cites W2153129798 @default.
• W2126161397 cites W2153307461 @default.
• W2126161397 cites W2162818956 @default.
• W2126161397 cites W2166646446 @default.
• W2126161397 cites W2168662701 @default.
• W2126161397 cites W2170791084 @default.
• W2126161397 cites W4239462698 @default.
• W2126161397 cites W4241541527 @default.
• W2126161397 cites W4317929224 @default.
• W2126161397 cites W4379476453 @default.
• W2126161397 doi "https://doi.org/10.3109/09553002.2013.782110" @default.
• W2126161397 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3700655" @default.
• W2126161397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23488537" @default.
• W2126161397 hasPublicationYear "2013" @default.
• W2126161397 type Work @default.
• W2126161397 sameAs 2126161397 @default.
• W2126161397 citedByCount "16" @default.
• W2126161397 countsByYear W21261613972013 @default.
• W2126161397 countsByYear W21261613972014 @default.
• W2126161397 countsByYear W21261613972015 @default.
• W2126161397 countsByYear W21261613972016 @default.
• W2126161397 countsByYear W21261613972017 @default.
• W2126161397 countsByYear W21261613972018 @default.
• W2126161397 countsByYear W21261613972019 @default.
• W2126161397 countsByYear W21261613972020 @default.
• W2126161397 countsByYear W21261613972021 @default.
• W2126161397 countsByYear W21261613972022 @default.
• W2126161397 crossrefType "journal-article" @default.
• W2126161397 hasAuthorship W2126161397A5014015669 @default.

• next