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• W2126186300 abstract "We generated purine nucleoside phosphorylase (PNP)-deficient mice to gain insight into the mechanism of immune deficiency disease associated with PNP deficiency in humans. Similar to the human disease, PNP deficiency in mice causes an immunodeficiency that affects T lymphocytes more severely than B lymphocytes. PNP knockout mice exhibit impaired thymocyte differentiation, reduced mitogenic and allogeneic responses, and decreased numbers of maturing thymocytes and peripheral T cells. T lymphocytes of PNP-deficient mice exhibit increased apoptosis in vivo and higher sensitivity to gamma irradiation in vitro. We propose that the immune deficiency in PNP deficiency is a result of inhibition of mitochondrial DNA repair due to the accumulation of dGTP in the mitochondria. The end result is increased sensitivity of T cells to spontaneous mitochondrial DNA damage, leading to T cell depletion by apoptosis." @default.
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• W2126186300 date "2000-06-19" @default.
• W2126186300 modified "2023-10-13" @default.
• W2126186300 title "Mitochondrial Basis for Immune Deficiency" @default.
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• W2126186300 doi "https://doi.org/10.1084/jem.191.12.2197" @default.
• W2126186300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193200" @default.
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