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• W2126189268 abstract "Sibutramine, a combined norepinephrine and serotonin reuptake inhibitor, is effective in the management of obese patients requiring pharmacotherapy as part of a multimodal approach to weight loss. It improves insulin resistance markers, glucose metabolism, and atherogenic dyslipidemia in both diabetic and nondiabetic patients, most of these effects resulting from weight loss. However, sibutramine exerts a peripheral sympathomimetic effect that induces a moderate increase in heart rate and attenuates the reduction in blood pressure attributable to weight loss or even slightly increases blood pressure. Since 2002, several cardiovascular adverse events (hypertension, tachycardia, arrhythmias, myocardial infarction) were reported in sibutramine-treated patients. This led to a contraindication of the use of this antiobesity agent in patients with established coronary heart disease, previous stroke, heart failure, or cardiac arrhythmias. The recent Sibutramine Cardiovascular Outcomes Trial (SCOUT) confirmed that subjects with preexisting cardiovascular disease (CVD) on long-term (5 years) treatment with sibutramine (10–15 mg/day) had a significantly increased risk for nonfatal myocardial infarction and nonfatal stroke, but not cardiovascular death or all-cause mortality. Because the benefit of sibutramine as a weight loss aid seems not to outweigh the cardiovascular risks, the European Medicines Agency (EMEA) recommended the suspension of marketing authorizations for sibutramine across the European Union (EU). The U.S. Food and Drug Administration (FDA) first stated that the drug should carry a “black box” warning because of an increased risk of stroke and heart attack in patients with a history of CVD. In October 2010, however, sibutramine was withdrawn from the U.S. market. After SCOUT, concern still persists about the effect of sibutramine on cardiovascular outcome.Obesity is a major cause of morbidity and mortality, predominantly through CVDs (1,2). The metabolic consequences of obesity, more particularly abdominal obesity associated with increased visceral adipose tissue, include atherogenic dyslipidemia, impaired glucose metabolism, hypertension, and …" @default.
• W2126189268 created "2016-06-24" @default.
• W2126189268 creator A5039563874 @default.
• W2126189268 date "2011-04-22" @default.
• W2126189268 modified "2023-09-23" @default.
• W2126189268 title "Sibutramine on Cardiovascular Outcome" @default.
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• W2126189268 doi "https://doi.org/10.2337/dc11-s205" @default.
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