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• W2126190388 abstract "peroxisome proliferator-activated receptors (PPARs) are nuclear receptors acting as lipid sensors. Besides its metabolic activity in peripheral organs, the PPAR beta/delta isotype is highly expressed in the brain and its deletion in mice induces a brain developmental defect. Nevertheless, exploration of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>action in the central nervous system remains sketchy. The lipid content alteration observed in PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>null brains and the positive action of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>agonists on oligodendrocyte differentiation, a process characterized by lipid accumulation, suggest that PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>acts on the fatty acids and/or cholesterol metabolisms in the brain. PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>could also regulate central inflammation and antioxidant mechanisms in the damaged brain. Even if not fully understood, the neuroprotective effect of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>agonists highlights their potential benefit to treat various acute or chronic neurological disorders. In this perspective, we need to better understand the basic function of PPAR<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>in the brain. This review proposes different leads for future researches." @default.
• W2126190388 created "2016-06-24" @default.
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• W2126190388 creator A5067434963 @default.
• W2126190388 date "2008-01-01" @default.
• W2126190388 modified "2023-09-24" @default.
• W2126190388 title "Peroxisome Proliferator-Activated Receptor<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>β</mml:mi><mml:mo>/</mml:mo><mml:mi>δ</mml:mi></mml:mrow></mml:math>in the Brain: Facts and Hypothesis" @default.
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• W2126190388 doi "https://doi.org/10.1155/2008/780452" @default.
• W2126190388 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2581793" @default.
• W2126190388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19009042" @default.
• W2126190388 hasPublicationYear "2008" @default.
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