FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126196596> ?p ?o ?g. }

• W2126196596 endingPage "882" @default.
• W2126196596 startingPage "876" @default.
• W2126196596 abstract "The antibody responses to a novel rapid-acting insulin analog, insulin aspart (IAsp), and their potential clinical correlates were studied with a specifically developed method in 2,420 people with diabetes treated for up to 1 year with preprandial subcutaneous injections of IAsp.Circulating insulin antibodies were analyzed by radioimmunoassay with (125)I insulin or IAsp tracers and polyethylene glycol precipitation. Four multinational, open, parallel group studies were conducted in Europe and North America, with a total of 1,534 people with diabetes exposed to IAsp and 886 people exposed to human insulin (HI) as meal-related insulin for 6-12 months.Insulin antibodies specific to HI or IAsp were absent in a majority of patients throughout the 6- to 12-month study periods. A majority of the patients (64-68%) had antibodies cross-reacting between HI and IAsp when entering the studies, with baseline levels (means +/- SD of percent bound/total) of 16.6 +/- 16.3% in study 1 and 10.3 +/- 14.0% in study 4. In all four studies, cross-reactive antibodies increased in patients exposed to IAsp, with a maximum at 3 months, and thereafter there was a decline toward baseline levels at 9-12 months (levels at 3 and 12 months: 22.3 +/- 19.7 and 16.8 +/- 16.5% in study 1 and 21.5 +/- 21.9 and 16.9 +/- 17.4% in study 4). Antibody levels showed similar changes in people with type 1 and type 2 diabetes, and there was no consistent relationship between antibody formation and glycemic control or between antibody formation and safety in terms of adverse events.Treatment with IAsp is associated with an increase in cross-reactive insulin antibodies, with a subsequent fall toward baseline values, without any indication of clinical relevance because no effect on efficacy or safety could be identified." @default.
• W2126196596 created "2016-06-24" @default.
• W2126196596 creator A5001086144 @default.
• W2126196596 creator A5015275535 @default.
• W2126196596 creator A5019447119 @default.
• W2126196596 creator A5039835598 @default.
• W2126196596 creator A5043396690 @default.
• W2126196596 creator A5087844534 @default.
• W2126196596 date "2002-05-01" @default.
• W2126196596 modified "2023-10-14" @default.
• W2126196596 title "Immune Responses to Insulin Aspart and Biphasic Insulin Aspart in People With Type 1 and Type 2 Diabetes" @default.
• W2126196596 cites W1584126509 @default.
• W2126196596 cites W2000628654 @default.
• W2126196596 cites W2021160326 @default.
• W2126196596 cites W2029699674 @default.
• W2126196596 cites W2030768028 @default.
• W2126196596 cites W2056705269 @default.
• W2126196596 cites W2058804545 @default.
• W2126196596 cites W2065443996 @default.
• W2126196596 cites W2066566805 @default.
• W2126196596 cites W2072452722 @default.
• W2126196596 cites W2104888919 @default.
• W2126196596 cites W2121606242 @default.
• W2126196596 cites W2160252336 @default.
• W2126196596 cites W4211174544 @default.
• W2126196596 cites W4249798907 @default.
• W2126196596 cites W964503500 @default.
• W2126196596 doi "https://doi.org/10.2337/diacare.25.5.876" @default.
• W2126196596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11978684" @default.
• W2126196596 hasPublicationYear "2002" @default.
• W2126196596 type Work @default.
• W2126196596 sameAs 2126196596 @default.
• W2126196596 citedByCount "98" @default.
• W2126196596 countsByYear W21261965962012 @default.
• W2126196596 countsByYear W21261965962013 @default.
• W2126196596 countsByYear W21261965962014 @default.
• W2126196596 countsByYear W21261965962015 @default.
• W2126196596 countsByYear W21261965962016 @default.
• W2126196596 countsByYear W21261965962018 @default.
• W2126196596 countsByYear W21261965962019 @default.
• W2126196596 countsByYear W21261965962020 @default.
• W2126196596 countsByYear W21261965962022 @default.
• W2126196596 countsByYear W21261965962023 @default.
• W2126196596 crossrefType "journal-article" @default.
• W2126196596 hasAuthorship W2126196596A5001086144 @default.
• W2126196596 hasAuthorship W2126196596A5015275535 @default.
• W2126196596 hasAuthorship W2126196596A5019447119 @default.
• W2126196596 hasAuthorship W2126196596A5039835598 @default.
• W2126196596 hasAuthorship W2126196596A5043396690 @default.
• W2126196596 hasAuthorship W2126196596A5087844534 @default.
• W2126196596 hasBestOaLocation W21261965961 @default.
• W2126196596 hasConcept C126322002 @default.
• W2126196596 hasConcept C134018914 @default.
• W2126196596 hasConcept C159654299 @default.
• W2126196596 hasConcept C176685330 @default.
• W2126196596 hasConcept C203014093 @default.
• W2126196596 hasConcept C2776664568 @default.
• W2126196596 hasConcept C2777180221 @default.
• W2126196596 hasConcept C2778199505 @default.
• W2126196596 hasConcept C2779306644 @default.
• W2126196596 hasConcept C2779908123 @default.
• W2126196596 hasConcept C2780473172 @default.
• W2126196596 hasConcept C2781232474 @default.
• W2126196596 hasConcept C3019948211 @default.
• W2126196596 hasConcept C555293320 @default.
• W2126196596 hasConcept C71924100 @default.
• W2126196596 hasConceptScore W2126196596C126322002 @default.
• W2126196596 hasConceptScore W2126196596C134018914 @default.
• W2126196596 hasConceptScore W2126196596C159654299 @default.
• W2126196596 hasConceptScore W2126196596C176685330 @default.
• W2126196596 hasConceptScore W2126196596C203014093 @default.
• W2126196596 hasConceptScore W2126196596C2776664568 @default.
• W2126196596 hasConceptScore W2126196596C2777180221 @default.
• W2126196596 hasConceptScore W2126196596C2778199505 @default.
• W2126196596 hasConceptScore W2126196596C2779306644 @default.
• W2126196596 hasConceptScore W2126196596C2779908123 @default.
• W2126196596 hasConceptScore W2126196596C2780473172 @default.
• W2126196596 hasConceptScore W2126196596C2781232474 @default.
• W2126196596 hasConceptScore W2126196596C3019948211 @default.
• W2126196596 hasConceptScore W2126196596C555293320 @default.
• W2126196596 hasConceptScore W2126196596C71924100 @default.
• W2126196596 hasIssue "5" @default.
• W2126196596 hasLocation W21261965961 @default.
• W2126196596 hasLocation W21261965962 @default.
• W2126196596 hasOpenAccess W2126196596 @default.
• W2126196596 hasPrimaryLocation W21261965961 @default.
• W2126196596 hasRelatedWork W1599472676 @default.
• W2126196596 hasRelatedWork W2054045531 @default.
• W2126196596 hasRelatedWork W2058323732 @default.
• W2126196596 hasRelatedWork W2067212927 @default.
• W2126196596 hasRelatedWork W2080135029 @default.
• W2126196596 hasRelatedWork W2129737421 @default.
• W2126196596 hasRelatedWork W2138540710 @default.
• W2126196596 hasRelatedWork W2143009184 @default.
• W2126196596 hasRelatedWork W2153745306 @default.
• W2126196596 hasRelatedWork W2374483849 @default.
• W2126196596 hasVolume "25" @default.
• W2126196596 isParatext "false" @default.

• next