Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126199679> ?p ?o ?g. }
- W2126199679 endingPage "1302" @default.
- W2126199679 startingPage "1293" @default.
- W2126199679 abstract "Reversible acetylation mediated by histone deacetylase (HDAC) influences a broad repertoire of physiological processes, many of which are aberrantly controlled in tumour cells. Since HDAC inhibition prompts tumour cells to enter apoptosis, small-molecule HDAC inhibitors have been developed as a new class of mechanism-based anticancer agent, many of which have entered clinical trials. While the clinical picture is evolving and the precise utility of HDAC inhibitors remains to be determined, it is noteworthy that certain tumour types undergo a favourable response, in particular haematological malignancies. Vorinostat (suberoylanilide hydroxamic acid) has been approved for treating cutaneous T-cell lymphoma in patients with progressive, persistent or recurrent disease. Here, we discuss developments in our understanding of molecular events that underlie the anticancer effects of HDAC inhibitors and relate this information to the emerging clinical picture for the application of HDAC inhibitors in haematological malignancies." @default.
- W2126199679 created "2016-06-24" @default.
- W2126199679 creator A5001022039 @default.
- W2126199679 creator A5005433828 @default.
- W2126199679 creator A5055001146 @default.
- W2126199679 creator A5075558980 @default.
- W2126199679 creator A5081342306 @default.
- W2126199679 date "2009-08-01" @default.
- W2126199679 modified "2023-10-15" @default.
- W2126199679 title "HDAC inhibitor-based therapies and haematological malignancy" @default.
- W2126199679 cites W1563624749 @default.
- W2126199679 cites W1602446144 @default.
- W2126199679 cites W1641419369 @default.
- W2126199679 cites W1967018540 @default.
- W2126199679 cites W1979832500 @default.
- W2126199679 cites W1993510744 @default.
- W2126199679 cites W2004800182 @default.
- W2126199679 cites W2005471059 @default.
- W2126199679 cites W2005527839 @default.
- W2126199679 cites W2009204250 @default.
- W2126199679 cites W2013186220 @default.
- W2126199679 cites W2013781993 @default.
- W2126199679 cites W2015886726 @default.
- W2126199679 cites W2020912062 @default.
- W2126199679 cites W2022285476 @default.
- W2126199679 cites W2022533018 @default.
- W2126199679 cites W2023962763 @default.
- W2126199679 cites W2037841266 @default.
- W2126199679 cites W2051890772 @default.
- W2126199679 cites W2052181006 @default.
- W2126199679 cites W2053631011 @default.
- W2126199679 cites W2064608106 @default.
- W2126199679 cites W2066260735 @default.
- W2126199679 cites W2070433411 @default.
- W2126199679 cites W2071115015 @default.
- W2126199679 cites W2078364998 @default.
- W2126199679 cites W2080057665 @default.
- W2126199679 cites W2087966689 @default.
- W2126199679 cites W2090926709 @default.
- W2126199679 cites W2096160655 @default.
- W2126199679 cites W2101979121 @default.
- W2126199679 cites W2102884982 @default.
- W2126199679 cites W2103619661 @default.
- W2126199679 cites W2103665811 @default.
- W2126199679 cites W2106357158 @default.
- W2126199679 cites W2107040737 @default.
- W2126199679 cites W2110957729 @default.
- W2126199679 cites W2110959000 @default.
- W2126199679 cites W2118335184 @default.
- W2126199679 cites W2128761802 @default.
- W2126199679 cites W2134644214 @default.
- W2126199679 cites W2135619784 @default.
- W2126199679 cites W2135830745 @default.
- W2126199679 cites W2140204965 @default.
- W2126199679 cites W2141920998 @default.
- W2126199679 cites W2143658931 @default.
- W2126199679 cites W2149386327 @default.
- W2126199679 cites W2150681906 @default.
- W2126199679 cites W2158010532 @default.
- W2126199679 cites W2163883199 @default.
- W2126199679 cites W2559269147 @default.
- W2126199679 cites W4211075966 @default.
- W2126199679 cites W4233171904 @default.
- W2126199679 cites W4240799078 @default.
- W2126199679 doi "https://doi.org/10.1093/annonc/mdn792" @default.
- W2126199679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19515748" @default.
- W2126199679 hasPublicationYear "2009" @default.
- W2126199679 type Work @default.
- W2126199679 sameAs 2126199679 @default.
- W2126199679 citedByCount "119" @default.
- W2126199679 countsByYear W21261996792012 @default.
- W2126199679 countsByYear W21261996792013 @default.
- W2126199679 countsByYear W21261996792014 @default.
- W2126199679 countsByYear W21261996792015 @default.
- W2126199679 countsByYear W21261996792016 @default.
- W2126199679 countsByYear W21261996792017 @default.
- W2126199679 countsByYear W21261996792018 @default.
- W2126199679 countsByYear W21261996792019 @default.
- W2126199679 countsByYear W21261996792020 @default.
- W2126199679 countsByYear W21261996792021 @default.
- W2126199679 countsByYear W21261996792022 @default.
- W2126199679 countsByYear W21261996792023 @default.
- W2126199679 crossrefType "journal-article" @default.
- W2126199679 hasAuthorship W2126199679A5001022039 @default.
- W2126199679 hasAuthorship W2126199679A5005433828 @default.
- W2126199679 hasAuthorship W2126199679A5055001146 @default.
- W2126199679 hasAuthorship W2126199679A5075558980 @default.
- W2126199679 hasAuthorship W2126199679A5081342306 @default.
- W2126199679 hasBestOaLocation W21261996791 @default.
- W2126199679 hasConcept C104317684 @default.
- W2126199679 hasConcept C119157956 @default.
- W2126199679 hasConcept C142724271 @default.
- W2126199679 hasConcept C185592680 @default.
- W2126199679 hasConcept C203014093 @default.
- W2126199679 hasConcept C2776202225 @default.
- W2126199679 hasConcept C2776262904 @default.
- W2126199679 hasConcept C2776281265 @default.
- W2126199679 hasConcept C2778305200 @default.