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- W2126202077 abstract "A 53-year-old man visited our hospital for evaluation of massive ascites and liver tumor. Concomitant liver disease was ruled out by the absence of risk factors for chronic liver disease. An abdominal computerized tomography showed a diffuse low-density area without enhancement in the right lobe (Figure A). Magnetic resonance imaging showed a low-signal-intensity area on T1-weighted images and a high-signal-intensity area in T2-weighted images in the right lobe. Superparamagnetic iron oxide magnetic resonance imaging showed no enhancement in the tumor. Portography showed stoppage of the right branch of the portal vein. Spindle-shaped and pleomorphic tumor cells proliferating within a hyalinized matrix were found on histopathologic examination. Intracytoplasmic vacuoles and neovascular channels also were present. Immunohistochemical evidence of endothelial differentiation, as shown by the presence of factor VIII–related antigen (Figure B), CD31, and CD34, was observed. This patient was diagnosed with a hepatic epithelioid hemangioendothelioma. For 4 months the hepatic tumor spread diffusely and liver function took a turn for the worse rapidly and the patient died.View Large Image Figure ViewerDownload Hi-res image Download (PPT) A primary malignant hepatic epithelioid hemangioendothelioma is a rare tumor with an incidence of less than 0.1 per 100,000 population.1Mehrabi A. Kashfi A. Fonouni H. et al.Primary malignant hepatic epithelioid hemangioendothelioma: a comprehensive review of the literature with emphasis on the surgical therapy.Cancer. 2006; 107: 2108-2121Crossref PubMed Scopus (314) Google Scholar Its vascular nature is confirmed by positive staining for factor VIII–related antigen and other endothelial cell markers (CD31 and CD34). We think early detection of hepatic epithelioid hemangioendothelioma is very difficult because of few characteristic symptoms without concomitant liver disease. If imaging findings are atypical, a liver biopsy examination and immunohistochemical staining should be performed." @default.
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- W2126202077 date "2007-05-01" @default.
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- W2126202077 title "Hepatic Epithelioid Hemangioendothelioma" @default.
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- W2126202077 doi "https://doi.org/10.1016/j.cgh.2007.03.005" @default.
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